Tsiaj Qauv|Kev Sib Tw Thiab Kev Siv Hauv Kev Kho Mob Tus Qauv Tsim Kho

Mob yog ib tug complex physiological phenomenon tshwm sim los ntawm lub activation ntawm sensory neurons hu ua nociceptors, pab raws li ib tug tseem ceeb kev tiv thaiv mechanism rau kab mob. Kev puas tsuaj lossis kab mob ntawm lub paj hlwb tuaj yeem ua rau mob neuropathic. Kev nkag siab tob txog lub paj hlwb cov txheej txheem thiab cov kev hloov pauv pathophysiological hauv qhov mob neuropathic yog qhov tseem ceeb rau kev txheeb xyuas cov hom phiaj kho tshiab thiab tsim cov tshuaj kho mob tshiab.

Mob mechanisms feem ntau categorized rau hauv peripheral thiab central mechanisms. Peripheral mechanisms feem ntau koom nrog cov thawj afferent fibers, nociceptors, thiab peripheral rhiab heev. Central mechanisms encompass central rhiab heev, disinhibition thiab txhim kho kev yooj yim, kev hloov kho, thiab ectopic excitability. Peripheral thiab central rhiab heev yog qhov tseem ceeb uas ua rau muaj kev tshwm sim tom qab- raug mob hyperalgesia. Peripheral sensitization yog ib qho tseem ceeb hauv kev mob inflammatory thiab qee yam mob neuropathic mob (xws li postherpetic neuralgia). Central rhiab heev tuaj yeem koom nrog hauv qhov mob inflammatory, mob neuropathic, thiab mob ua haujlwm. Disinhibition thiab txhim kho kev yooj yim, txhim kho kev tsim kho, thiab ectopic excitability yog cov txheej txheem tshwj xeeb hauv kev mob neuropathic.

Hauv cov tsiaj sim, kev ntsuas qhov mob feem ntau yog nyob ntawm kev soj ntsuam tus cwj pwm tsis zoo, xws li paw tshem tawm reflex, nquag licking lossis khawb, hnav khaub ncaws ntau dhau, hais lus, txo tus cwj pwm tshawb nrhiav, nce kev coj cwj pwm, thiab kev hloov ntawm lub ntsej muag. Thaum cov tsiaj nyob rau hauv lub xeev mob pathological, qhov mob rhiab heev ua rau muaj kev txhawb zog rau cov stimuli thiab txo qhov mob. Txawm tias qhov mob me me tuaj yeem ua rau muaj kev hloov pauv ntawm tus cwj pwm tseem ceeb, xws li paw tshem tawm, licking, lossis mob plab. Yog li ntawd, thaum kev sim, cov kws tshawb fawb tuaj yeem siv cov kev xav tshwj xeeb uas siv cov cuab yeej sim lossis cov tshuaj reagents los ua kom muaj kev hloov pauv tus cwj pwm hauv cov tsiaj, yog li hloov qhov mob hnyav mus rau qhov muaj nuj nqis rau kev ntsuas qhov mob. Tam sim no, ntau txoj hauv kev los ntsuas qhov mob rhiab heev hauv cov tsiaj muaj xws li cov tshuab, thermal, thiab kev ntsuas qhov mob txias.

Daim ntawv thov ntawm Pain Models:

Cov qauv mob yog cov cuab yeej tseem ceeb rau kev kawm txog kev mob mechanisms, tshuaj mechanisms ntawm kev ua, thiab tshuaj xyuas cov tshuaj ua tau zoo thiab kev nyab xeeb, muab pov thawj tseem ceeb rau kev txhim kho tshuaj.

Common Tsiaj Hom:

Nas, nas, tsis yog- tib neeg primates (liab), luav, npua, thiab lwm yam.

Common Pain Models thiab Model Tsim Methods:

• Tus qauv mob o:CFA Model: Mob inflammatory mob tshwm sim los ntawm kev txhaj tshuaj subcutaneous ntawm Complete Freund's Adjuvant, feem ntau siv rau cov nas thiab nas.
• Formalin qauv:luv-lub sij hawm thiab ntev- lub sij hawm mob teb tshwm sim los ntawm subcutaneous los yog intradermal txhaj tshuaj formalin, feem ntau siv rau cov nas thiab nas.
• Neuropathic Mob Models:
• Nerve Injury Model:Neuropathic mob tshwm sim los ntawm kev phais tsim cov hlab ntsha raug mob, xws li ib feem ntawm cov hlab ntsha sciatic transection lossis compression, feem ntau siv rau cov nas thiab nas.
• Tus Qauv Zauv: Chronic Constriction Injury (CCI)Mob mob neuropathic mob tshwm sim los ntawm ligating cov hlab ntsha sciatic lossis lwm cov hlab ntsha peripheral, feem ntau siv rau hauv nas.
• Capsaicin Model: Nociceptive pain induced local or systemic injection of capsaicin to activate nociceptors.
• Tshuaj Kho Mob Model:Acetic Acid Model: Cov mob hauv zos uas tshwm sim los ntawm subcutaneous lossis intraperitoneal txhaj ntawm acetic acid, feem ntau siv rau cov nas thiab nas.
• Mob Cancer Model:Mob qog nqaij hlav los ntawm kev hloov cov qog hlwb rau hauv cov tsiaj, feem ntau siv rau hauv nas thiab nas. Cov qauv tsim qauv muaj xws li kev phais phais thiab txhaj tshuaj.

Cov Kev Sib Tw Hauv Kev Siv Cov Qauv Mob Cov Ntaub Ntawv rau Kev Ntsuas Tshuaj thiab Kev Txhim Kho:

• Tus kheej Variability:Qhov cuam tshuam tseem ceeb ntawm -tsiaj hloov pauv hauv kev nkag siab rau qhov mob stimuli tuaj yeem cuam tshuam kev txhais lus thiab rov ua dua tshiab ntawm cov txiaj ntsig kev sim.
• Qauv Xaiv:Kev xaiv tus qauv mob tsim nyog yuav tsum tau ua tib zoo xav txog cov hom phiaj kev sim, cov lus nug tshawb fawb, hom tsiaj, thiab lwm yam. Cov qauv sib txawv tuaj yeem ua raws li ntau hom kev mob.
• Kev txhais lus kho mob:Cov qauv tsiaj tsis tuaj yeem rov ua dua qhov nyuaj ntawm tib neeg kev mob, ua rau muaj kev sib tw hauv kev txhais cov kev tshawb pom los ntawm cov qauv tsiaj mus rau kev siv tshuaj kho mob.
• Kev txiav txim siab ncaj ncees:Cov kev sim siv cov qauv mob yuav tsum nruj me ntsis ua raws li cov lus qhia txog kev coj ncaj ncees, suav nrog kev txo qis cov tsiaj siv thiab ua kom muaj txiaj ntsig zoo rau tsiaj thiab kev tiv thaiv thoob plaws hauv cov txheej txheem sim.

Prisys Biotech tau tsim thiab siv tau ntau yamtsis yog-tib neeg primate mob qauv. Peb muaj peev xwm kho cov qauv kev daws teeb meem zoo raws li cov neeg siv khoom xav tau kev tshawb fawb thiab kev siv tshuaj ua haujlwm. Peb cov kev pabcuam suav nrog cov qauv thiab kev xaiv tsiaj txhu, tswj kev tsim, sau cov ntaub ntawv thiab tshuaj xyuas, Pawg Saib Xyuas Tsiaj thiab Siv Siv (IACUC), tshuaj xyuas biomarker, thiab lwm yam.

Prisys Biotech cov kws tshawb fawb pab pawg, los ntawm kev ua kom zoo tshaj plaws thiab cov tswv yim, tau mob siab rau kev txhim kho cov qauv kev ntseeg siab thiab kev kwv yees, thiab txhim kho cov ntaub ntawv rov tsim dua tshiab thiab sib piv, daws cov teeb meem hauv kev mob tus qauv tsim thiab siv. Peb lub hom phiaj los muab cov neeg siv khoom nrog cov ntaub ntawv txheeb xyuas tshuaj muaj tseeb thiab raug, ua kom yooj yim rau kev ua tiav ntawm kev tshawb fawb tshuaj preclinical thiab soj ntsuam.