Txij thaum hluas mus txog rau thaum cev xeeb tub, poj niam physiology nthuav tawm qhov tshwj xeeb ntawm cov teeb meem kev noj qab haus huv.Endometriosis, ib qho mob ntev uas cuam tshuam txog kwv yees li 10% ntawm cov poj niam thiab cov ntxhais ntawm lub hnub nyoog yug me nyuam, yog qhov mob tsis tu ncua, cuam tshuam rau cov neeg mob lub neej zoo. Cov teeb meem ntawm cev xeeb tub tseem yog ib qho ua rau poj niam tuag thoob ntiaj teb, thiab tom qab-menopause, cov poj niam muaj kev nce zuj zus ntawm cov pob txha pob txha thiab kev pheej hmoo ntawm cov kab mob plawv ntau ntxiv piv rau cov txiv neej.
Hais txog cov teeb meem tseem ceeb ntawm cov poj niam kev noj qab haus huv no, Prisys Biotech tau mob siab rau kev ua kom nrawm rau kev tshawb fawb los ntawm kev txhim kho cov qauv tsiaj uas muaj tseeb. Peb tau ua tiav kev tsim qauvMacaca fascicularis (Cynomolgus macaques) qauvencompassing cov kab mob tseem ceeb xws li endometriosis thiab postpartum hemorrhage, muab cov kev sim tseem ceeb rau kev tsim tshuaj tshiab.
Endometriosis: Modeling a Chronic Estrogen-Tus kab mob nyob ntawm
Endometriosis yog ib qho kab mob uas tsis tshua muaj mob ntev uas cuam tshuam txog kwv yees li 190 lab tus poj niam thiab cov ntxhais ntawm hnub nyoog yug me nyuam thoob ntiaj teb. Nws pathophysiology yog txhais los ntawm kev loj hlob ectopic ntawm endometrial-zoo li cov ntaub so ntswg sab nraum lub tsev me nyuam kab noj hniav, feem ntau tshwm sim raws li dysmenorrhea hnyav, mob pelvic mob, thiab muaj peev xwm infertility. Raws li ib tug complex estrogen-dependent mob, endometriosis tuaj yeem tshwm sim los ntawm menarche mus rau menopause.
Macaca fascicularis Endometriosis Model
Qauv Tsim:
Covendometriosis qauvyog tsim los rov ua dua cov yam ntxwv tseem ceeb ntawm endometriosis, qhov chaw endometrial{{0}zoo li cov ntaub so ntswg loj hlob sab nraum tsev menyuam. Peb tus qauv Macaca fascicularis siv kev phais kev hloov pauv ntawm cov ntaub so ntswg autologous endometrial los tsim kom muaj homologous thiab tiv thaiv kab mob- sib xws. Cov chaw hloov pauv tshwj xeeb thiab cov txheej txheem phais yog ua haujlwm los ua kom muaj ntau hom kab mob endometriotic.
Cov yam ntxwv ntawm tus qauv:
Kev tsim qauv ua tiav tau ua tiav hauv kev tsim cov yam ntxwv ntawm cov kab mob endometriotic ntawm cov chaw hloov pauv. Cov kab mob no zoo ib yam li tib neeg endometrial cov ntaub so ntswg histologically thiab nthuav tawm cov ntshav los ntshav, tsom rau cov pathophysiology ntawm tib neeg endometriosis. Cov tsiaj qauv tuaj yeem pom cov kab mob endometriosis- cov tsos mob ntsig txog. Lub xub ntiag thiab cov yam ntxwv ntawm cov kab mob endometriotic tuaj yeem raug soj ntsuam los ntawm kev pom thiab kev soj ntsuam histopathological.
Pharmacodynamic Study Applications:
Tus qauv Macaca fascicularis endometriosis yog ib qho cuab yeej tseem ceeb rau kev soj ntsuam kev ua tau zoo ntawm kev kho mob endometriosis tshiab. Nws yog qhov tsim nyog rau kev ntsuam xyuas ntau yam kev kho mob uas tsom mus rau endometriosis. NtsiabpharmacodynamicCov ntsiab lus kawg suav nrog kev hloov pauv ntawm cov yam ntxwv ntawm qhov txhab thiab qhov cuam tshuam kev kho mob.
Txhawm rau kom tau txais cov ntaub ntawv qhia ntxaws ntxaws lossis sib tham txog koj cov kev xav tau tshawb fawb tshwj xeeb, thov hu rau peb.
Tom qab yug me nyuam: Ib Lub Neej-Kev Tshawb Fawb Txog Kev Kub Ntxhov Thaum Ntxov thiab Tsiaj Tsiaj
Thaum lub sij hawm cev xeeb tub, leej niam circulating ntshav ntim thiab extravascular kua ntim nce, nrog rau lub xeev hypercoagulable thiab nce qib ntawm placental corticosteroids. Cov kev hloov pauv ntawm lub cev no txhim kho cov niam txiv kam rau cov ntshav poob, muaj peev xwm npog cov cim qhia ntxov ntawm kev poob siab. Txawm li cas los xij, postpartum hemorrhage (PPH) tseem yog ib qho xwm txheej tshwm sim ntau tshaj plaws thiab tseem ceeb heev. Tshwj xeeb tshaj yog nyob rau hauv tawm - ntawm - tsev kho mob xa khoom, cov ntshav tsis tswj tau thaum ntxov tuaj yeem tsis pom thiab tsis tswj hwm. Thaum cov tsos mob tshwm sim tshwm sim, cov neeg mob feem ntau tau nce mus rau nruab nrab mus rau qhov kev poob siab loj heev, tsis pom lub qhov rais zoo rau kev resuscitation. Tsim cov qauv tsiaj ntawm hemorrhagic shock nyob rau hauv cev xeeb tub yog ib qho tseem ceeb ntawm cov tswv yim tseem ceeb rau hauv - kev tshawb nrhiav qhov tob ntawm cov txheej txheem ntawm kev poob siab ntawm leej niam, kev ua kom zoo ntawm cov tswv yim ntawm leej niam resuscitation, thiab txhim kho cov txiaj ntsig resuscitation. Prisys Biotech tau ua tiav cov qauv Macaca fascicularis tom qab yug me nyuam hemorrhage, tso lub hauv paus ruaj khov rau kev tshawb fawb ntsig txog.
Macaca fascicularis Postpartum Hemorrhage Model
Qauv Tsim:
Postpartum hemorrhage (PPH) is defined as vaginal bleeding exceeding a certain threshold (typically >500ml) tsis pub dhau 24 teev tom qab yug menyuam. Tus qauv Macaca fascicularis PPH yog tsim los simulate pathophysiology ntawm tib neeg postpartum hemorrhage, tshwj xeeb tshaj yog los ntshav los ntawm uterine atony lossis placental yam. Peb tau tsim cov qauv muaj zog kom ua tau zoo raws li cov txheej txheem tseem ceeb ntawm cov txheej txheem pathological.
Cov yam ntxwv ntawm tus qauv:
Tus yam ntxwv tseem ceeb ntawm tus qauv Macaca fascicularis PPH yog ib qho kev nce ntxiv hauv qhov chaw mos tom qab los ntshav. Hauv cov xwm txheej hnyav, qhov no tuaj yeem ua rau muaj kev poob siab hypovolemic. Tus qauv tuaj yeem raug ntsuas los ntawm kev saib xyuas cov cim tseem ceeb ntawm lub cev.
Pharmacodynamic Study Applications:
Qhov no tsis yog -tib neeg primate PPH qauv ua haujlwm ua tus qauv zoo tshaj plaws rau kev soj ntsuam kev ua tau zoo ntawm cov tshuaj hemostatic thiab cov tshuaj uterotonic hauv kev kho PPH. Nws tuaj yeem siv los ntsuas qhov ua tau zoo ntawm ntau yam tshuaj kho. NtsiabpharmacodynamicCov ntsiab lus kawg suav nrog ntshav poob thiab cuam tshuam txog physiological tsis.
Yog xav paub ntxiv txog cov ntaub ntawv xov xwm lossis tham txog koj cov kev xav tau kev tshawb fawb tshwj xeeb, thov hu rau peb.
Saib tom ntej: Cov qauv Precision tsav lub neej yav tom ntej ntawm Cov Poj Niam Kev Tshawb Fawb Kev Noj Qab Haus Huv
Ob xyoo dhau los, lub ntiaj teb poj niam lub neej expectancy tau nce los ntawm 5.3 xyoo, thiab cov niam txiv tuag tau poob 34%. Cov kev ua tiav no qhia txog qhov muaj txiaj ntsig zoo ntawm kev tshawb fawb tshawb fawb tsom rau poj niam txoj kev noj qab haus huv. Prisys Biotech tau cog lus rau kev tsim kho thev naus laus zis txuas ntxiv, tsim kho cov kab mob ntsig txog tsiaj cov kab mob los txhawb kev txhim kho cov tshuaj tshiab rau cov poj niam-cov kab mob, thiab nthuav dav txoj hauv kev noj qab haus huv rau cov poj niam ntawm txhua lub hnub nyoog thiab cheeb tsam.
Txij thaum hluas mus txog rau thaum cev xeeb tub, cov poj niam ntsib teeb meem kev noj qab haus huv thiab ntau haiv neeg thoob plaws lawv lub neej. Kev loj hlob ntawmprecision tsiaj qauvtsis tsuas yog tso cai rau siab -kev ncaj ncees simulation ntawm cov yam ntxwv tseem ceeb ntawm cov kab mob pathophysiological ntawm poj niam cov kab mob tab sis kuj tseem muab kev txhawb nqa zoo rau hauv - kev tshawb nrhiav qhov tob ntawm cov txheej txheem kab mob thiab kev siv tau zoo ntawm cov tswv yim kho mob. Peb ntseeg tau tias nrog kev nce qib ntawm kev tshawb fawb thiab kev tsim kho tshiab ntawm biotechnology tsis tu ncua, cov qauv tshiab no yuav pab tau cov kws tshawb fawb kom kov yeej cov kev tshawb fawb tsis tu ncua, ua kom cov tshuaj tshiab hauv cov poj niam noj qab haus huv, thiab tiv thaiv kev noj qab haus huv ntawm cov poj niam thoob plaws hauv lawv lub neej.
