NHP Intracerebral (ICM) Txhaj|Prisys Biotech
Precision Intracerebral (ICM) Kev Pabcuam Txhaj Tshuaj hauv NHPs
Kev txhaj tshuaj Intracerebral (ICM) yog ib txoj hauv kev tshwj xeeb hauv kev tswj hwm uas tso cai rau kev xa ncaj qha ntawm cov kev kho mob mus rau hauv cov cheeb tsam hauv lub hlwb, hla cov ntshav-hlwb teeb meem thiab ua tiav qhov kev raug mob hauv zos. Txoj hauv kev no yog qhov tseem ceeb tshaj plaws rau kev txhim kho cov noob kev kho mob, kev kho mob ntawm tes, thiab lub hom phiaj biologics xav tau kev koom tes meej ntawm cov qauv neural tshwj xeeb.
Prisys Biotechnologies muab stereotaxic, duab- coj kev txhaj tshuaj intracerebral nyob rau hauv tsis yog- tib neeg primates (NHPs), txhawb kev txhais lus CNS kev tshawb fawb los ntawm qhov ua tau thaum ntxov mus rau kev tshawb fawb preclinical siab heev. Los ntawm kev siv peb cov advancedtsis yog -tib neeg primates platform, cov kws tshawb fawb tuaj yeem ua tiav qhov tsis tau pom dua hauv kev xa tshuaj hauv zos.
Kev saib xyuas
Prisys muaj kev sib koom ua ke ICM platform uas tsim los rau kev xa mus rau cov cheeb tsam hauv lub hlwb, xws li putamen, hippocampus, cortex, thiab thalamus. Qhov kev pabcuam no tshwj xeeb yog tsim nyog rau cov haujlwm uas xav tau kev siv tshuaj hauv zos siab, qhov chaw -kev qhia tshwj xeeb, lossis kev cuam tshuam hauv cheeb tsam. Peb lub peev xwm tseem ceeb suav nrog:
- Targeted Delivery:Kev them nyiaj yug rau noob caj noob ces, kab mob vectors, thiab biologics rau hauv lub hlwb ua haujlwm.
- Stereotaxic phais:Cov txheej txheem intracranial meej tau ua raws li kev taw qhia siab tshaj plaws.
- Kev ntsuas kev nyab xeeb:Cov ntawv tshaj tawm dav dav- cov txheej txheem kev ua haujlwm thiab kev ntsuas kev nyab xeeb kom ntseeg tau tias muaj feem cuam tshuam rau kev kho mob.
Cov peev txheej tseem ceeb
MRI-Guided Stereotaxic Targeting
Kev txheeb xyuas qhov tseeb yog qhov tseem ceeb rau kev kawm ICM. Prisys integrates MRI imaging nrog stereotaxic systems kom pab tau peb - lub hlwb lub hom phiaj ntawm sub-millimetric precision, kom ntseeg tau tias muaj kev ntseeg siab thiab rov tsim dua rau hauv thaj chaw anatomical predefined.
Flexible Brain Region Targeting
Kev txhaj tshuaj tswj tau raug kho raws li cov hom phiaj kev kawm, tso cai rau lub hom phiaj meej ntawm lub hlwb ua haujlwm. Qhov kev hloov pauv no txhawb nqa ntau yam kev siv, suav nrog cov qauv kab mob neurodegenerative, kev txav mus los, thiab focal CNS pathologies. Rau kev siv cov paj hlwb dav dav, peb kuj muab kev txhaj tshuaj intracerebroventricular (ICV) ua lwm txoj hauv kev.
Tswj Micro-Volume Delivery
Siv cov txheej txheem cannula zoo thiab tswj cov tshuaj infusion, Prisys ua kom muaj kev noj tshuaj kom raug thiab txo qis cov ntaub so ntswg cuam tshuam, uas yog qhov tseem ceeb rau kev tshawb fawb CNS rhiab heev thiab kev txhais lus sib xws.
Integrated Safety thiab Functional Assessment
ICM cov kev tshawb fawb ntawm Prisys tau txais kev txhawb nqa los ntawm cov txheej txheem kev ntsuam xyuas dav dav, suav nrog kev soj ntsuam kuaj mob, kev tshuaj xyuas histopathological ntawm cov chaw txhaj tshuaj, thiab kev tshuaj xyuas tus cwj pwm siv peb AI-raws li NHP Kev Ntsuas Tus Cwj Pwm. Qhov no yog qhov tseem ceeb thaum ntsuas cov qauv xws li covMPTP-induced Parkinson's disease (PD) qauv.
Tus nqi txhais lus rau CNS Drug Development
ICM kev tswj hwm muab qhov tshwj xeeb zoo hauv CNS kev txhim kho tshuaj los ntawm kev ua kom muaj kev sib koom tes ncaj qha hauv cov qauv hlwb tshwj xeeb. Qhov no ua rau muaj ntau dua cov tshuaj hauv zos lossis cov noob qhia ntau dua piv rau cov kab mob lossis CSF-raws li txoj hauv kev, thaum txo qis kev raug mob thiab tawm ntawm- cov teebmeem. Txoj kev no yog qhov tshwj xeeb tshaj yog muaj txiaj ntsig rau cov kab mob neurological tsawg thiab cov tswv yim zoo neuromodulation.
FAQ
Q: Thaum twg yog qhov kev txhaj tshuaj intracerebral (ICM) nyiam tshaj IT lossis ICV txoj kev?
A: ICM yog qhov zoo dua yog tias qhov tseeb, qhov chaw xa mus rau thaj tsam ntawm lub hlwb yog qhov yuav tsum tau ua, tshwj xeeb tshaj yog rau kev kho cov noob lossis cov xwm txheej uas lub hom phiaj kev koom tes yuav tsum txwv rau cov qauv anatomical.
Q: Hom kev kho twg zoo tshaj plaws rau kev tswj hwm ICM?
A: ICM yog dav siv rau AAV-raws li kev kho noob caj noob ces, kho cell, thiab biologics uas yuav tsum tau muaj siab nyob rau hauv lub zos concentration los yog tsom qhia nyob rau hauv lub hlwb.
Q: Yuav ua li cas Prisys ua kom raug thiab kev nyab xeeb hauv ICM cov txheej txheem?
A: Prisys ua ke nrog MRI-cov txheej txheem qhia stereotaxic, pab pawg kws phais neeg paub txog, tswj cov thev naus laus zis thev naus laus zis, thiab cov lus qhia dav dav- cov txheej txheem saib xyuas kom ntseeg tau siab thiab nyab xeeb.
Cov ntaub ntawv
1. Bankiewicz, KS, et al. (2016). Convection- txhim kho kev xa khoom ntawm AAV2-GDNF hauv cov tsiaj tsis yog tib neeg. Human Gene Therapy.
2. Samaranch, L., et al. (2019). Direct Intracerebral Administration ntawm AAV Vectors: Kev Siv Tshuaj Kho Mob thiab Kev Txiav Txim Siab Preclinical. Gene Therapy Journal.
Cim npe nrov: NHP Intracerebral (ICM) Txhaj|Prisys Biotech, kev tshawb fawb, kev tshawb fawb, liab, tshuaj kho noob
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