Pharmacokinetics (PK)
Nkag siab txog Pharmacokinetics (PK) thiab vim li cas DMPK hauv NHP tseem ceeb
Pharmacokinetics (PK) yog qhov kev tshawb fawb ntau ntawm cov tshuaj li cas absorbed, faib, metabolized, thiab tawm los ntawm lub cev. Nws suav nrog kev siv lej los piav qhia txog lub sijhawm hloov pauv ntawm cov tshuaj concentration hauv ib lub cev. Kev tshawb fawb PK yog qhov tseem ceeb rau kev txiav txim siab cov txheej txheem ntawm kev nqus tshuaj, biodistribution, metabolism, thiab tshem tawm. Cov kev tshawb fawb no yog ib qho tseem ceeb rau kev txhim kho tshuaj raws li lawv muab cov ntaub ntawv tseem ceeb rau kev ntsuas cov tshuaj preclinical thiab kev nyab xeeb.
Biologics muab cov txiaj ntsig zoo rau cov neeg mob uas mob ntev thiab / lossis mob hnyav ua tsaug rau lawv qhov tshwj xeeb muaj zog rau cov hom phiaj kho. Raws li qhov tshwm sim ntawm qhov tshwj xeeb no, tsis yog tib neeg primates (NHP) feem ntau yog tib hom kab mob preclinical uas kho cov tshuaj tiv thaiv kab mob sib kis nrog lub hom phiaj. PK cov ntaub ntawv tsim tawm hauv NHPs tau koom ua ke nrog cov ntaub ntawv hauv vitro los kwv yees qhov concentration / cuam tshuam kev sib raug zoo hauv tib neeg, thiab yog li ntawd txhais cov koob tshuaj kom raug sim hauv thawj zaug hauv tib neeg kev sim. Qhov zoo sib xws hauv cov txheej txheem txhais cov tshuaj pharmacokinetics thiab pharmacodynamics (PKPD) ntawm biologics hauv NHP thiab tib neeg tau txhim kho lub peev xwm ntawm kev tshawb xyuas preclinical.
Dab tsi tshwj xeeb qhov tseem ceeb Prisys tuaj yeem muaj hauv NHP PK / PD?
Xaiv Prisys Biotech kom txhim khu kev qha, raug, thiab ua tiav hauv vivo PK cov kev tshawb fawb uas txhawb nqa koj cov kev xav tau kev txhim kho tshuaj.
Integrated Hauv Vivo PK Txoj Kev
- Peb kev sib koom ua ke tsis sib haum xeeb hauv kev tshawb nrhiav tshawb pom muab qhov yooj yim thiab ua haujlwm tau zoo rau ntau haiv neeg hauv vivo profileing xav tau.
Kev txawj ntse hauv DMPK
- Peb muab kev nkag siab zoo ntawm cov tshuaj metabolism thiab cov tshuaj pharmacokinetics, txhawb kev txhim kho tshuaj thaum ntxov.
PK kawm txog ntau hom tsiaj
- Tsis yog tib neeg primates (Cynomolgus macaques)
- Cov dev / Mini npua
Organ-targeted Drug Delivery Platform, rau kev txhim kho hauv zos concentration ntawm cov hom phiaj kho mob hauv NHP
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Kev nthuav dav dav dav thiab kev xa tawm hauv lub cev: xyuas kom meej ntxiv ntawm qhov txuas (Kev Tshawb Fawb Txog Kev Nyab Xeeb )
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BBB-bypassing thiab Precise hlwb tswj: xyuas kom meej ntxiv ntawm qhov txuas (iMRI Lub hlwb xa khoom )
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Tsawg-invasive organ perfusion nyob rau hauv Digital Subtraction Angiography (DSA): xyuas kom meej ntxiv ntawm qhov txuas (Clinical Imaging )
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Lwm cov kev siv tshuaj tshwj xeeb: intrathecal, intra-ocular, imager-facilitated, microscopic
Cov kev paub dhau los thiab kev txawj ntse hauv kev tswj hwm kev ua haujlwm hauv lub neej NHP Biofluids / cov ntaub so ntswg sampling
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Ultrasound-guided ntaub so ntswg biopsy: siab, raum
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Endoscopic Biopsy: BALF, plab hnyuv / plab mucosal
Tsawg-invasive: tawv nqaij, leeg, adipose
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Catheterized biofluids: CSF, Endovascular ntshav (xws li los ntawm cov hlab ntsha hepatic)
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Wedge-biopsy los ntawm kev phais tsis muaj menyuam: daim siab, lub raum, lub ntsws, tus po
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Brian soft tissue biopsy: ntawm iMRI Brain Navigation
Ntau yam kev sim ntsuas
- Tshuaj Metabolism: LC-MS, Xov tooj cua-isotope labeling
- Immunogenicity: Flow cytometry, ADA, ELISpot
- Biomarkers: Kev kuaj ntshav / zis, ELISA, qPCR
- Pathology Lab: Histopathology, IHC
Raum biopsy thiab IHF forC3 hauv IgAN Model
Prisys Biotech muaj nplooj siab xav txhawb koj txoj kev txhim kho tshuaj nrog kev txhim khu kev qha thiab muaj txiaj ntsig PK kev kawm. Hu rau peb hnub no kom paub ntau ntxiv txog yuav ua li cas peb tuaj yeem pab koj ua tiav koj cov hom phiaj tshawb fawb.
Pharmacokinetics (PK) yog dab tsi?
Pharmacokinetics (PK) tsom rau kev nkag siab tias cov tshuaj cuam tshuam li cas nrog cov kab mob muaj sia. Tshwj xeeb, nws tshuaj xyuas cov txheej txheem ntawm kev nqus, kev faib tawm, cov metabolism, thiab tshem tawm (ADME) ntawm cov tshuaj. Hauv vivo PK cov kev tshawb fawb yog qhov tseem ceeb rau kev ua kom ntseeg tau tias cov neeg sib tw tshuaj muaj cov tshuaj pharmacokinetic tsim nyog uas tuaj yeem soj ntsuam hauv cov kev tshawb fawb preclinical. Cov kev tshawb fawb no muab cov ntaub ntawv tseem ceeb, suav nrog tib neeg cov koob tshuaj sib npaug (HED), tsis muaj kev cuam tshuam (NOEL), thiab cov neeg tsav tsheb pharmacokinetic/pharmacodynamic (PK/PD). Qhov tseem ceeb PK tsis xws li thaj tsam hauv qab nkhaus (AUC), kev tshem tawm, ib nrab-lub neej, ntim ntawm kev faib tawm, qhov siab tshaj plaws (Cmax), thiab qhov siab tshaj plaws (Cmin) raug txiav txim los ntawm cov kev tshawb fawb no.
Cim npe nrov: Pharmacokinetics (PK), kev tshawb fawb, kev tshawb fawb, liab, tshuaj kho noob
Koj Tseem Yuav Zoo Li
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