Retinitis Pigmentosa (RP) NHP Qauv

Retinal degenerative kab mob xws liRetinitis Pigmentosa (RP)thiab qhuavHnub nyoog-txog Macular Degeneration (AMD)sawv cev loj ua rau irreversible tsis pom kev poob thoob ntiaj teb. Txawm hais tias muaj kev nce qib tseem ceeb hauv kev kho cov tshuaj molecular thiab noob, kev txhais lus sib txawv ntawm cov qauv nas thiab tib neeg cov kab mob hauv lub qhov muag tseem yog ib qho teeb meem loj rau kev soj ntsuam tshuaj preclinical.

NtawmPrisys Biotechnologies, peb tau tsim ibnonhuman primate (NHP) qauv ntawm RP induced los ntawm intravitreal sodium iodate (NaIO₃)los txuas qhov kev faib kev txhais lus no. Kev siv cov txheej txheem thiab kev ua haujlwm zoo sib xws ntawm primate retina rau tib neeg, tus qauv no muab lub platform txhim khu kev qha thiab muaj txiaj ntsig zoo rau kev soj ntsuam cov kev kho tshiab uas tsom rau cov retinal degeneration, RPE dysfunction, thiab o - kho qhov muag tsis pom kev.

Sodium iodate xaiv ua kom puas cov xim ntawm lub paj hlwb epithelial (RPE), ua rau cov photoreceptor degeneration thiab cov retinal thinning. Thaum siv rau cynomolgus liab (Macaca fascicularis), qhov induced pathology ze recapitulates cov yam ntxwv tseem ceeb ntawm tib neeg retinal degenerative kab mob:

Cov txiaj ntsig tseem ceeb:

• Kev cuam tshuam ntawm tus qauv:Optical coherence tomography (OCT) qhia txog ellipsoid cheeb tsam (EZ) poob, punctate hyperreflective deposits saum RPE txheej, thiab cim retinal thinning nyob rau hauv 14 hnub tom qab-induction.

• Kev ua haujlwm tsis zoo:Flash electroretinogram (ERG) cov lus teb ua rau pom qhov tsis tuaj yeem thim rov qab, qhia txog kev ua haujlwm tsis zoo ntawm photoreceptor.

  Kev hloov pauv nyiaj txiag:Fluorescein angiography (FFA) txheeb xyuas cov kab mob hyperfluorescent hauv cheeb tsam uas cuam tshuam rau RPE kev puas tsuaj.

• Histopathology:RPE cell clustering, pigment deposition, thiab photoreceptor disorganization paub meej tias cov txheej txheem degeneration.

• Cov lus teb Molecular:Upregulation ntawm complement Cheebtsam (C3, CFB) thiab chemokines (CCL-2) qhia ua kom cov kab mob inflammatory thiab tiv thaiv kab mob txuam nrog RPE kev nyuaj siab thiab retinal atrophy.

• High translational ntsig txog:Lub primate retina qhia cov qauv macular, cone ntom, thiab tiv thaiv kab mob microenvironment nrog tib neeg, muab cov txiaj ntsig zoo tshaj plaws ntawm cov nas.

• Kev ntsuas ntau -modal:Kev sib koom ua ke ntawm OCT, FFA, ERG, thiab kev soj ntsuam histopathological tso cai rau kev nthuav dav, tib neeg- kho mob-style nyeem ntawv.

  Stable thiab reproducible pathology:Retinal degeneration thiab tsis pom kev ua haujlwm tau zoo ib yam ntawm cov ntsiab lus thiab lub sijhawm, txhawb kev ntsuas kev ua tau zoo.

• Customizable tsim:Nyob ntawm cov txheej txheem kho mob -antioxidant, anti-inflammatory, neuroprotective, los yog regenerative-peb muab cov kev kawm tsim qauv thiab ntau yam- kev ntsuas lub sijhawm.

Prisys 'NHP RP qauv muab ntau yam platform rau:

• Kev ntsuam xyuas ua ntej ntawm kev kho tshiab rau RP, AMD qhuav, thiab RPE- cov tswv yim tiv thaiv;
• Mechanistic kev tshawb fawb ntawm oxidative kev nyuaj siab, ntxiv ua kom muaj zog, thiab retinal tiv thaiv kab mob;
• Kev soj ntsuam ntawm kev xa tshuaj ocular thiab pharmacokinetics hauv lub cev muaj feem cuam tshuam rau lub cev;
• Kev lees paub ntawm cov duab biomarkers txhais tau rau tib neeg qhov chaw kho mob kawg.

Los ntawm kev sib koom ua ke AAALAC- tau lees paub cov chaw NHP nrog cov duab pom kev zoo siab thiab cov thev naus laus zis electrophysiological,Prisys Biotechnologiesmuab kev tshawb fawb nruj thiab kho tau hauv vivo kev tshawb fawb rau kev tshawb nrhiav kab mob retinal degenerative.

Peb txais tos kev koom tes nrog cov kws tshawb nrhiav kev kawm thiab cov neeg koom tes biopharmaceutical txaus siab rau kev txhais lus ophthalmology thiab NHP pharmacology.

Hu rau peb los tham txog yuav ua li cas peb tus qauv RP tuaj yeem ua kom koj txoj kev tshawb pom tau mus rau qhov chaw kho mob tau zoo.

Cim npe nrov: retinitis pigmentosa (rp) nhp qauv, kev tshawb fawb, kev tshawb fawb, liab, noob kev kho mob