Aaval - - synuclein overexurcression NHP qauv

Hauv kev nrhiav cov kev hloov pauv rauTus kab mob Parkinson (Pd), qhov kev xaiv ntawm cov qauv ua ntej yog qhov ntsuas rau kev txhais lus hauv chaw kuaj mob. Thaum tus qauv ntawm MptP Neurotoxin qauv tau ua haujlwm ua cov cuab yeej tseem ceeb, nws "Endept Simulation" mus kom ze rau kev ua haujlwm ntawm tib neeg pd. Qhov kev txwv no yog qhov tshwj xeeb tshaj rau kev txhim kho cov kab mob niaj hnub- kev kho mob (DMTS).

Ntawm prisys biotechnologies, pebNhp txhais tes neuroscience platformmuaj kev nce qib tseem ceeb: tusAav (adeno {{- Cov Phooj Ywg) {1} - synucedin} synlexavourceCov. Peb muab qhov no sawv cev rau lub paradigm ua haujlwm los ntawm kev ua qauv ntawm tus kab mob ntawm tus kab mob, muab cov hauv paus tsis muaj txiaj ntsig rau koj cov kev tshawb nrhiav pd.

Tus MptP qauv induces, tsis - Tshwj xeeb dopaminergic Neurotaltherity tsis tau replicate lub cheeb tsam etmark patmark ntawm PD:Qhov tsim ntawm lub cev leewy, uas yog feem ntau tsim ntawm Aggregated - synuclein protein.

Cov prisys aav - Raws li cov lus qhia ncaj qha no cov tub ntxhais kawm. Los ntawm kev ua haujlwm Aav Vectors rau lub hom phiaj xa ntawm tus neeg- synostin pathade ntawm protein pathade, misfoulder, thiab kev sib sau ua ke hauv lub hlwb primate.

Cov Ntsiab Lus Tseem Ceeb:

• Kev txhim kho kev pathological txheeb xyuas:Koj cov kev tshawb fawb tuaj yeem nug ncaj qha rau lub luag haujlwm ntawm - synuclein. Kho cov neeg sib tw ua rau muaj kev tshem tawm lossis cuam tshuam qhov kev sib sau ua pov thawj ntau dhau ntawm tus kab mob - hloov kho cov nyhuv.
• Kev ua kom tiav qhov kawg nkaus:Raws li tau pom los ntawm peb lub peev xwm platform, peb tsim nyog peb cov qauv tsis yog los ntawm cov peev txheej hauv tsev, xws li} Synuclein (Pser129 s), tus qauv kub rau cov synucleinopathy.

Tib neeg PD tau tshaj tawm los ntawm qeeb, muaj kev ntxhov siab tsis muaj Neurodegeneration uas nthuav tawm ntau xyoo. Tus mob hnyav uas tau thuam los ntawm MPTP tsis zoo cuam tshuam qhov kev ua mob tiv thaiv no, txwv tsis pub muaj kab mob ntev} {{2 {2} hloov kev cuam tshuam.

Lub aav - - synuclein qauv zoo nkauj zoo nkauj no. Tus kab ntxwv - Kev siv cov protein qhia thiab ua rau niajotoxicity sawv cev aqeeb, progressive cov txheej txheem uas hloov pauv ntau hliCov. Qhov no muab ib qho khoom siv hluav taws xob invaluable for:

• Kawm tus kab mob Dynamics:Taug qab cov evolution ntawm biomarkers thiab kev coj tus cwj pwm los ntawm thaum ntxov mus txog qib kawg.
• Soj ntsuam DMT kev ua tau:Kev ntsuas seb koj tus neeg sib tw uas kho tau tseebqeeb, nres, lossis rov qabKab mob dhau los, tsis yog li muab cov tsos mob hloov pauv.
• Nrhiav cov tshiab biomarkers:Kev soj ntsuam ntev ntev hloov pauv, xws li kev nce qib poob ntawm dopaminic neurons ntawm vmat2 tus tsiaj yees duab, txhawm rau txheeb xyuas cov kws kuaj mob thaum ntxov lossis cov chaw muag tshuaj thaum ntxov.

Kev laus yog ib qho tseem ceeb tshaj plaws rau kev ua yeeb yam pd.Qhov kev tshawb fawb no yog lub hauv paus ntawm peb lub tswv yim muaj zog tshaj plaws. Thaum intsoling pathology rau cov neeg laus laus tso cai rau kev kawm ntawm ib tus neeg tsav tsheb ib leeg, qhia} synucleinopathy rau ib qhohnub nyoog nhp hlwbTso cai rau peb tshawb xyuas qhov kev sib cuam tshuam ntawm kev sib cuam tshuam ntawmSenescence thiab Proteinopathy.

Cov hau kev no ua rau txoj kev kawm txog li cas cov laus corular ib puag ncig nrog kev sib cuam tshuam nrog cov qauv pathogenic, tsim cov qauv ntawm cov chaw kuaj mob tsis sib haum xeeb rautib neeg sporadic pd, cov nyiaj twg rau ntau tshaj 90% ntawm txhua kis. Cov ntaub ntawv thiab cov lus xaus tsim los ntawm cov qauv no muaj kev zam tshwj xeeb ntawm tus nqi thiab kev tsim kho tshiab, muab koj cov kev tshawb fawb ntawm lub chaw tom teb.

Tag

Cov neeg ua haujlwm biotechnologies Aaving - - synuclein overexurter nhp qauv yog ntau tshaj ib cuab; Nws yog lub platform ntse kom tau txais kev nkag siab tob rau hauv pathogenesis ntawm Parketison tus kab mob. Los ntawm kev sib xyawpathologation fidelity, ntsuas dej ntev, thev naus laus zis, thiab qhov tseem ceeb ntawm kev laus, peb muab cov kev ua kom ruaj khov thiab cov kab mob cuam tshuam rau kev sim cov kab mob tom ntej no - hloov kho cov tshuaj kho.

Tus khub nrog prisys los ua kom nrawm koj cov pip siv hluav taws xob pipeline thiab txhais koj cov txiaj ntsig scientific rau cov txiaj ntsig muaj txiaj ntsig.

Cim npe nrov: Aaval - - Syuclein One Synuclein Otterex Gradression NHP qauv kev tshawb fawb, kev tshawb nrhiav, kev kho tus kheej