Toxicokinetics (TK)

Toxicokinetics (TK) kawm txog tus cwj pwm ntawm cov tshuaj nyob rau theem tshuaj lom, tsom rau kev nqus, faib, metabolism, thiab kev tso tawm (ADME). Prisys Biotech muaj cov kev pabcuam TK tag nrho, suav nrog ntau hom kev xaiv xa tshuaj, kev sau cov qauv siab, thiab ntau yam kev sim tshuaj ntsuam xyuas, los txhawb kev tshuaj xyuas kev nyab xeeb thiab kev txhim kho tshuaj.

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Khoom Taw qhia

Toxicology, kev nyab xeeb pharmacology thiab kev nyab xeeb tshuaj preclinical

Toxicokinetics (TK)yog ib lub sij hawm muab los ntawm toxicology thiab kinetics, feem ntau hu ua "toxicant kinetics" los yog "toxicity kinetics." Daim teb no muab cov hauv paus ntsiab lus los ntawm pharmacokinetics los tshawb txog qhov tshwm sim thiab kev loj hlob ntawm cov tshuaj toxicity. Nws ua kom muaj nuj nqis kawm txog kev nqus, kev faib tawm, cov metabolism, thiab kev tso tawm (ADME) ntawm cov tshuaj ntawm cov tshuaj lom neeg, muab lub hauv paus rau kev tshawb fawb txog tshuaj lom thiab kev soj ntsuam kev nyab xeeb.

Dab tsi tshwj xeeb qhov tseem ceeb Prisys tuaj yeem muab rau hauv kev tshuaj xyuas kev nyab xeeb tshuaj hauv NHP?

Extensive Experience & Regulatory Expertise:

Prisys khav theeb cov ntaub ntawv pov thawj hauv kev ua ntau yam kev tshawb fawb txog kev nyab xeeb thiab tsim cov ntaub ntawv zoo tsim nyog rau IND xa, ua kom muaj kev tswj hwm kev tswj hwm thiab kev txhim kho tshuaj zoo.

Clinically Translatable Safety Insights:

Leveraging advanced technologies zoo lihauv vivo imaging thiab ib pab neeg tshwj xeeb ntawm NHP kws kho tsiaj thiab ib tus kws kho mob tib neeg, Prisys muab kev soj ntsuam txog kev nyab xeeb thiab kev kuaj mob kws tshaj lij, cuam tshuam qhov sib txawv ntawm kev tshawb fawb txog kev kho mob thiab kev kho mob.

Kev Ntsuam Xyuas Neurotoxicity:

Prisys siv cov tswv cuabBehaviorAtlas ™ 3D motion quantification thiab telemetry implants rau kev ntsuam xyuas neurotoxicity siab heev, ua kom meej meej thiab lub hom phiaj kev soj ntsuam ntawm cov tshuaj cuam tshuam rau lub paj hlwb.

Tshwj xeeb Technical Prowess:

Peb pab neeg muaj kev txawj ntse nyob rau hauv cov txheej txheem nyuaj, nrog rau kev tuav cov terminal sampling nyuaj (xws li,tob hlwb nuclei ), xyuas kom meej thiab txhim khu kev qha cov ntaub ntawv los ntawm ntau lub hom phiaj hauv nruab nrog cev.

Robust & Integrated NHP Qauv:

Prisys siv cov yam ntxwv zooNHP qauv Hauv kev tshawb fawb txog kev nyab xeeb pharmacology, suav nrog thaj chaw tseem ceeb xws li hematology, metabolism, ua haujlwm ua pa, thiab CNS cuam tshuam, muab kev nkag siab zoo rau cov tshuaj tiv thaiv kev nyab xeeb.

Comprehensive Toxicokinetic (TK) Peev Xwm:

Prisys muab cov kev tshawb fawb TK sib xyaw ua ke, muaj ntau yam kev xaiv xa mus rau cov tshuaj, cov qauv kev sau qoob loo thiab cov txheej txheem ua tiav, thiab ntau yam kev sim tshuaj ntsuam xyuas, kom ntseeg tau tias muaj zog thiab ntxaws TK tsom xam tseem ceeb heev rau kev soj ntsuam kev nyab xeeb tshuaj.

Intrathecal

Injection into target organs/sites through catheter ports

Txhaj tshuaj rau hauv lub cev / qhov chaw los ntawm cov chaw nres nkoj catheter

Interventional injection through blood vessels under DSA (heart, liver, kidney, brain, etc.)

Kev txhaj tshuaj los ntawm cov hlab ntsha hauv DSA (lub plawv, siab, raum, hlwb, thiab lwm yam)

Yog xav paub ntxiv txog peb cov kev pabcuam TK lossis tham txog koj cov kev xav tau tshwj xeeb, thov hu rau peb rau kev pabcuam kws tshaj lij.

Tiv tauj peb kom paub ntxiv

FAQ

Q: Toxicokinetics (TK) yog dab tsi?

A: Toxicokinetics (TK) suav nrog kev siv cov tshuaj pharmacokinetic kom nkag siab tias cov tshuaj coj li cas ntawm cov tshuaj lom. Nws lub hom phiaj los qhia txog cov txheej txheem ntawm ADME ntawm cov tshuaj lom neeg thiab tsim kom muaj kev sib raug zoo ntawm kev raug mob, qib ntau npaum li cas, thiab kev nce qib ntawm cov tshuaj lom. TK cov kev tshawb fawb yog ib qho tseem ceeb rau toxicology raws li lawv piav qhia txog kev raug tshuaj yeeb tshuaj thiab nws qhov kev sib raug zoo nrog koob tshuaj thiab lub sij hawm, pab hauv kev ntsuam xyuas kev nyab xeeb ntawm kev soj ntsuam raws li kev tshawb pom tsis yog tshuaj toxicology.

Q: Lub Hom Phiaj Tseem Ceeb thiab Cov Haujlwm ntawm TK Studies

Systemic Exposure Description: Quantitatively piav qhia txog kev raug mob hauv cov tsiaj thiab nws txoj kev sib raug zoo nrog cov tshuaj lom thiab lub sijhawm.
Kev sib raug zoo ntawm koob tshuaj thiab kev nqus: nkag siab txog kev sib raug zoo ntawm cov koob tshuaj ntau thiab kev nqus, nrog rau kev sib txawv ntawm poj niam txiv neej.
Rov ua dua cov teebmeem: Qhia meej qhov cuam tshuam ntawm kev rov ua dua ntawm cov tshuaj metabolism thiab kinetics.
Tshuaj Txhaum Tshuaj thiab Lub Hom Phiaj Lub Hom Phiaj: Txiav txim seb qhov chaw thiab qhov twg ntawm cov tshuaj tsub zuj zuj, kwv yees lub hom phiaj ntawm lub cev rau toxicity, thiab elucidate cov txheej txheem ntawm kev ua tshuaj lom los ntawm kev raug thiab kev tshawb fawb raws sij hawm.
Toxic Response Identification: Txheeb xyuas seb puas muaj toxicity tshwm sim los ntawm niam txiv cov tshuaj los yog nws cov metabolites thiab qhia meej txog hom kev sib txawv ntawm cov tshuaj lom.
Kev txhawb nqa rau Toxicology Study Design: Teem TK dosing regimens nrog rau cov kev tshawb fawb toxicology los txhim kho kev tsim cov kev tshawb fawb tsiaj toxicology, suav nrog hom thiab xaiv koob tshuaj.
Extrapolation rau Tib Neeg: Sib piv cov tsiaj thiab tib neeg cov kab mob sib kis los txhais cov ntaub ntawv toxicology, tsim kom muaj kev sib raug zoo ntawm kev tshawb fawb tshuaj toxicology thiab koob tshuaj kho mob, thiab xyuas kom muaj kev nyab xeeb ntawm kev kho mob.
Kev taw qhia rau Kev Tsim Tshuaj Tshiab: Muab kev taw qhia hauv kev tsim cov tshuaj tshiab kom tsis txhob muaj cov tshuaj lom hauv niam txiv los yog cov tshuaj metabolites.

Cim npe nrov: Toxicokinetics (TK), kev tshawb fawb, kev tshawb fawb, liab, tshuaj kho noob

Tug

Pharmacokinetics (PK)

Tom ntej

ADME

Koj Tseem Yuav Zoo Li

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