Prisys Biotech's Cynomolgus Monkey Psoriasis Qauv: nce khoom ua ntej tshuaj yuav muag khoom muag tshuaj

Taw qhia: Qhov xav tau ntawm Psoriasis NHP Qauv Qauv

Psoriasis yog tus mob nqaij daim tawv nqaij mob Cov kev tshawb fawb preclinianics yog qhov tseem ceeb ntawm kev txhim kho tshuaj tshiab, thiab xaiv cov qauv tsiaj tsim nyog yog qhov tseem ceeb. Cov khoom siv uas nquag siv Imiquimod (imq)-kiv cua psoriasis qauv tau ua lub luag haujlwm hauv kev txhim kho kev siv tshuaj thaum ntxov. Txawm li cas los xij, lub cev sib txawv thiab kev txhaj tshuaj sib txawv ntawm nas thiab tib neeg txwv kev nrhiav txiaj ntsig ntawm cov qauv no.Cov Lus Qhia Tsis Yog Tib Neeg (NHPs), vim lawv cov kev hloov pauv, muaj sia, thiab txhaj tshuaj tsis zoo ib yam rau tib neeg, muab cov qauv uas cuam tshuam ntau rau Psoriasis.

Kev tiv thaiv kab mob hauv psoriasis

Cov kab mob pathogenesis ntawm psoriasis yog ib qho txheej txheem nyuaj ntawm lub network dystras dysregulation, los ntawm kev sib cuam tshuam ntawm innate thiab kev hloov pauv ntawm kev tiv thaiv. Ntau lub cytokines, tshwj xeeb tshaj yog it -17, tnf-, thiab}}, Ua si cov tawv nqaij tseem ceeb hauv kev pib ua si thiab hyperproliferation. Biologic agents targeting these key cytokines and pathways (such as anti-TNF- , anti-IL-17, and anti-IL-23 antibodies) have become essential in the treatment of psoriasis.

Tsis yog-tib neeg cov kev qhia, xws li cynomolgus liab, muaj daim tawv nqaij anatomy, tsis muaj zog ntawm tes sib txawv, thiab muaj nuj nqi uas yog cov homologous rau tib neeg. Qhov no kaw lub cev sib thooj ua rau NHP psoriasis qauv tshwj xeeb rau tib neeg psorismis, thiab kwv yees kev tshuaj tiv thaiv kev ua haujlwm.

Piv rau cov qauv qws, NHP psoriasis qauv muaj ntau dua:

• Simulates muaj tus kab mob pathophysiology: NHP Daim tawv Hlau Teeb Meem thiab Cov Cheeb Tsam Thaj Tsam Teb Cov Pathwulation yog ze rau tib neeg, tso cai rau kev siv tsis taus ntau ntawm cov psoriasis.
• Ntsuas kev tsom xam yeeb tshuaj thiab ua tau zoo: Cov tshuaj metabolism enzyme ntawm NHPs zoo ib yam li tib neeg, ua rau lawv cov tshuaj uas muag tshuaj thiab lub hom phiaj kev twv xyuas kev paub.
• Ua cov tshuaj ntsuam xyuas cov tshuaj ntev thiab kev ntsuas kev nyab xeeb: Lub cuab tam sim ntawm NHP yog cov ua ke ntau dua nrog tib neeg, ua rau lawv tsim qauv tshuaj mus ntev thiab mob ntev.

Prisys biotech tau tsim ib qhoImq-induced psoriasis qauvSiv cynomolgus liab los txhawb cov chaw muag tshuaj precliniamics rau psoriasis ntsig txog kev kho cov neeg sawv cev.

Qauv qauv kev txhim kho: Cov qauv no siv cov ntawv thov cov ntsiab lus ntawm Imiquimod (imq) kom ntxias cov tawv nqaij tawv nqaij hauv cynomolgus liab. Imq, ib tug TLR7 / 8 Agonist, ua kom muaj zog tiv thaiv kab mob hauv Innas, simulating tsis muaj zog tiv thaiv kab mob patiaphysiological ntawm psoriasis.

Kev sim tsim kho txheej txheem:

• Tsiaj: Cov Neeg Loj Poj Niam Cynomolgus macaques (cynomolgus macaque).
• Induction: Cov ntaub ntawv thov ntawm imq ua kom haum.
• Qhov chaw thov: Cheeb Tsam tshwj xeeb rau sab nraub qaum (thaj chaw qauv).

Pawg:

• Tsheb Pab Pawg: Imq stimulation + tsheb tswj (roj av jelly).
• Pab Pawg Kho: Imq stimulation + kho tshuaj (Daivobet).

Kev Tshuaj Xyuas Kev Ntsuas:

• Daim tawv nqaij lesion ntsuas: Quantitative Qhov Kev Ntsuas Loj Ua Haujlwm raws li Erehahema, exudation, dentquation, thiab lwm yam.
• Cov tawv nqaij Histopathology: Nws staining cov ntaub so ntswg los ntsuas tus Epidermal hyperplasia, mob hlwb ntawm tes infiltration, thiab lwm yam kev sib tw.
• Kev tsom xam cytokine: Cov qib ntawm cov ntsiab lus cytokenates hauv cov tawv nqaij homogenates lossis ntshav qab zib (piv txwv li}}} {1}}, thiab tnf-).
• Cov noob caj noob hlav:RT-QPCL los ntsuas qhov nthuav qhia ntawm cov yeeb yam psoriasis (xws li}}}}}}}}}}}}} {4} {}}}
• Lwm Cov Cuab Yeej: Cov tawv nqaij hnyav, qhov chaw nyob ntawm qhov chaw mob txhab, epidermal tuab, thiab lwm yam. (Yeem).

Qauv sim cov ntaub ntawv:

• Lesion qhab nia sib: Tom qab imq stimulation, cov qib lesion nyob rau hauv ob pab pawg ntawm lub tsheb thiab cov pab pawg kho tau nce ntxiv, lees paub kev ua tiav ntawm kev ua tiav. Tom qab Dimivobet kev kho, cov qhab nia lesion txo qis (P<0.05), indicating therapeutic efficacy. The Vehicle group showed consistently higher lesion scores.

• Cov txheej txheem keeb kwm: Keeb kwm kev tsom xam tawm thickening ntawm epidermal splease txheej, hyperkeratosis, thiab dermal infilmatory cell, zoo ib yam li tib neeg psoriasis patorology. Cov pab pawg Daivobet Diivobet tau pom tau qhov tseem ceeb los ntawm cov kev hloov pauv no.

• Cytokine Ntes:QPCR cov txiaj ntsig tau pom ntau ntau ntawm IL -17}}}}, thiab lwm qhov tseem ceeb cytokines nyob rau hauv tus qauv pawg, haum nrog psoriasis pathogenesis. Nyob rau hauv pab pawg kho, cov cytokine ntau tau txo qis tom qab kev cuam tshuam tshuaj.
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• Pigh kab mob mimicry:Tus qauv noh
• Kev Ntsuam Xyuas Qhov System:Kev ntsuas kev ntsuas ntau cov txheej txheem kev ntsuas cov tshuaj muaj txiaj ntsig ntawm kev ua yeeb tshuaj ntawm parshology, immunology, thiab kev kho mob raug.
• KAWG Kev Siv Tswv Yim: Cov txheej txheem qauv kev txhim kho thiab kev tshuaj xyuas cov txheej txheem ua kom muaj kev ntseeg tau thiab rov ua cov ntaub ntawv sim.
• Ua kom nrawm kev txhim kho: Muab cov ntaub ntawv muaj txiaj ntsig zoo preclinical ntawm cov ntaub ntawv tshuaj tshiab, tswj kev kuaj mob sai li cas.

Tag: Prisys biotech'sCynomolgus Monkey ImQ-induced psoriasis qauvMuaj cov qauv kev kaw lus ntau rau cov tsiaj ntawv muaj feem cuam tshuam rau cov kws tshawb muag hluav taws xob ua ntej. Cov qauv no ua rau kev ntsuas kev ua tau zoo dua ntawm kev ua tau tshuaj tshiab tshuaj tshiab, txhawb cov kev tshawb nrhiav hauv cov tshuaj tiv thaiv kev ua haujlwm hauv cov tshuaj tshiab hauv cov tshuaj tshiab hauv cov tshuaj tshiab.

Tiv Tauj Peb: Yog xav paub ntxiv txog prisys biotech's imq-induced pioriasis qauv, thov mus saib peb pab neeg lag luam ntawm {}}}}}.

Hais txog prisys biotech: Peysys Biotech, nyob hauv Shanghai, yog cov lag luam siab ua haujlwm tshwj xeeb hauv kev siv tshuaj thiab kev txhim kho thev naus laus zis. Lub tuam txhab yog Aaalac Tag nrho cov ntawv pov thawj thiab muabNtau hom tsiajTxog kev tshawb fawb tus kabmob, kev tshawb fawb ntawm chaw muag tshuaj, kev ntsuas kev nyab xeeb, biomarmer kev tshawb fawb, thiab kev siv mechanism siv tau. Prisys biotech sib koom tes nrog cov tuam txhab ua lag luam sab saum toj, cov tuam txhab kev kawm rau kev tsim kho tshuaj thiab kev txhim kho.