Cov tshuaj Peptide, suav nrog luv luv amino acid chains, yog ib chav kawm ntawm cov kws tshuaj uas muaj cov txiaj ntsig tseem ceeb ntawm cov tshuaj me me thiab cov khoom siv biologics, xws li lawv qhov tshwj xeeb, qis dua toxicity, thiab yooj yim ntawm synthesis. Cov tshuaj no qhia tau hais tias muaj peev xwm hauv kev tsom mus rau ntau yam kab mob metabolic xws li ntshav qab zib, rog rog, thiab kab mob plawv los ntawm kev tswj hwm cov haujlwm ntawm cov tshuaj hormones, receptors, thiab cov metabolism hauv-txog enzymes.
Txawm li cas los xij, cov teeb meem xws li qhov ncauj tsis muaj bioavailability, ceev enzymatic degradation, thiab immunogenicity tsim teeb meem rau cov tshuaj peptide. Txhawm rau daws cov no, cov kws tshawb fawb tau siv ntau yam kev tawm tswv yim los txhim kho lawv cov tshuaj pharmacokinetic thiab cov tshuaj pharmacodynamic, suav nrog cov tswv yim xws li cyclization, siv cov ntawv cog lus pseudopeptide, tsis yog -natural amino acids, thiab peptide hloov kho zoo li PEGylation.
Hais txog kev tiv thaiv kab mob, Prisys xav kom ntsuas qhov kev pheej hmoo ntawm immunogenicity ntawm cov tshuaj peptide tiv thaiv ntau yam tsis zoo, suav nrog cov khoom lag luam, txheej txheem -txog yam, tus neeg mob- muaj feem cuam tshuam, thiab kev sim tshuaj ntsuam xyuas. Tshwj xeeb tshaj yog, Prisys pom zoo rau txoj hauv kev los ntawm kev txheeb xyuas cov tshuaj tiv thaiv - tshuaj tiv thaiv kab mob (ADA), thiab ntsuas qhov cuam tshuam ntawm ADA ntawm cov tshuaj pharmacokinetics (PK), pharmacodynamics (PD), kev ua tau zoo, thiab kev nyab xeeb.
Raws li rau lub siab toxicity, Prisys sau tseg tias daim siab feem ntau ua lub luag haujlwm me hauv kev tshem tawm cov tshuaj peptide, uas feem ntau hydrolyzed los ntawm proteases thiab peptidases hauv lub cev. Uas tau hais tias, Prisys pom zoo kom ua cov kev tshawb fawb txog cov neeg mob uas muaj lub siab tsis zoo nyob rau hauv cov xwm txheej tshwj xeeb: thaum cov tshuaj peptide metabolism los ntawm hepatic enzymes surpasses 20%, los yog thaum cov tshuaj yog conjugated nrog ib tug lipid Cheebtsam uas yuav khi rau serum albumin los yog lwm yam lipid constituents, muaj feem xyuam rau cov kab mob nyob rau hauv cov neeg mob.
Ntawm cov ncauj lus ntawm kev siv tshuaj -kev sib cuam tshuam tshuaj, Prisys qhia tias cov tshuaj peptide tsis zoo li yuav yog cov tshuaj substrates, inhibitors, los yog inducers ntawm CYP enzymes thiab transporters tshwj tsis yog lawv tau hloov kho - xws li cyclization, uas tuaj yeem ua rau muaj kev cuam tshuam rau lub siab enzyme metabolism. Prisys qhia ntxiv tias qee cov tshuaj peptide tuaj yeem hloov pauv cov tshuaj pharmacokinetics ntawm cov tshuaj uas tau muab coj los ua ke raws li lawv cov
Ntxiv Paracetamol Bioavailability tom qab lub tes tsho Gastrectomypharmacological teebmeem, xws li GLP-1 receptor agonists, uas tuaj yeem ncua kev ua pa ntawm plab.
FDA tsis ntev los no tau tshaj tawm tsab ntawv qhia txog kev tshuaj xyuas tshuaj rau cov khoom siv tshuaj peptide, qhia txog qhov tseem ceeb thiab cov ntaub ntawv tshawb fawb txog kev txhim kho cov tshuaj peptide suav nrog kev tiv thaiv kab mob, kab mob siab, tshuaj - tshuaj sib cuam tshuam, thiab QT ncua ntev.
Ib rooj plaub ntawm cov ntsiab lus yog semaglutide, GLP-1 receptor agonist ua raws li cov tshuaj hormones ntuj GLP-1's cuam tshuam rau kev txhawb nqa insulin tso tawm thiab inhibiting glucagon secretion, yog li pab txo qis cov ntshav qabzib. Semaglutide, siv rau kev kho mob ntshav qab zib hom 2 thiab rog rog, muaj qhov hnyav ntawm molecular ntawm 4.1 kDa thiab tau txuas nrog cov roj fatty acid, yog li txhawb nqa albumin khi thiab ua kom ntev ib nrab neej. Cov tshuaj no tau ua kom pom kev ua tau zoo thiab kev nyab xeeb hauv kev sib piv rau lwm cov GLP receptor agonists thiab lwm cov tshuaj tiv thaiv kab mob ntshav qab zib hauv ntau qhov kev sim tshuaj, thiab nws cov kev tswj hwm subcutaneous ib zaug ib lim tiam txhawb kev ua raws li tus neeg mob.
Cov kev tshawb fawb kws tshuaj tshuaj ntsuam xyuas cov tshuaj pharmacokinetics, pharmacodynamics, immunogenicity, thiab tshuaj -kev sib cuam tshuam ntawm cov tshuaj semaglutide hauv ntau cov qauv ntawm cov pej xeem, xws li cov neeg ua haujlwm noj qab haus huv, cov neeg mob lub raum lossis lub siab tsis zoo, thiab cov neeg mob koom nrog- noj cov tshuaj hauv qhov ncauj, tau piav qhia txog semaglutide cov tshuaj tiv thaiv kab mob qis, thiab cov tshuaj tiv thaiv kab mob tsawg. tshuaj-kev sib tshuam tshuaj. Semaglutide ua tus piv txwv ntawm yuav ua li cas cov tshuaj peptide tuaj yeem hloov kho cov kab mob metabolic los ntawm kev muab cov txheej txheem tshiab ntawm kev ua, kev ua tau zoo thiab kev nyab xeeb, thiab kev tswj xyuas yooj yim.
Prisys Biotech, lub koom haum tshawb fawb saum toj kawg nkaus -tier daim ntawv cog lus tshwj xeeb hauv kev ua haujlwm hauv vivo cov kev sim nrog tsis yog- tib neeg primates thiab lwm hom, xa cov kev tshawb fawb kev txhais lus dav dav, txuas ntxiv "ib- nres" cov kev daws teeb meem rau ntau yam kev sim tsiaj. Lawv cov kev pabcuam muaj xws li kev soj ntsuam tshuaj, kev soj ntsuam kev nyab xeeb, kev tshawb fawb kev txhais lus, kev tshawb fawb biosafety, thiab lwm yam.
Prisys Biotech tuav lub hom phiaj ntawm kev coj ncaj ncees thiab kev noj qab haus huv tsiaj hauv lawv txoj kev kawm. Lawv kuj tseem qhia txog kev sib koom tes kev tsim kho uas tso cai rau cov neeg siv khoom khaws cov cuab yeej txawj ntse nrog rau cov txiaj ntsig ntawm kev txhawb nqa tshwj xeeb los ntawm Prisys Biotech.
