IPF Tshuaj Txhim Kho Kev Sib Tw Thiab Kev daws|NHP Cov Qauv Nrog CT Imaging & PFT - Xov Xwm

Idiopathic pulmonary fibrosis (IPF) yog ib qho mob ntev, nce zuj zus, thiab thaum kawg tuag kab mob ntsws interstitial uas tshwm sim los ntawm kev rov qab tsis tau ntawm lub ntsws parenchyma. Txawm hais tias muaj kev tshawb fawb ntxiv, kev txhim kho cov kev kho mob zoo rau IPF tseem nyuaj heev. Ib qho ntawm cov teeb meem tseem ceeb yog nyob rau hauv qhov txwv tsis pub txhais lus ntawm cov qauv ua ntej, tshwj xeeb yog cov qauv nas, uas feem ntau tsis tuaj yeem rov hais dua cov txheej txheem pathological thiab lub cev muaj zog pom hauv tib neeg IPF.

IPF Drug Development Imaging and PFT

Txhawm rau hais txog qhov sib txawv no, Prisys Biotechnologies tau tsim ib qho chaw kho mob uas tsis yog -tib neeg primate (NHP) qauv ntawmMob ntsws Fibrosis. Los ntawm kev sib koom ua ke cov duab kho mob siab heev nrog kev soj ntsuam ua pa ua pa, lub platform no muab cov txheej txheem kev txhais lus rau kev soj ntsuam kev soj ntsuam zoo ntawm kev tiv thaiv -fibrotic kho.

Kev sib tham ntawm Immune Mechanisms thiab Pulmonary Pathology

Lub pathogenesis ntawm IPF cuam tshuam tsis tau tsuas yog rov raug mob rau alveolar epithelial hlwb tab sis kuj dysregulation ntawm lub zos tiv thaiv microenvironment. Cov ntaub ntawv pov thawj ntxiv qhia tias kev tiv thaiv kab mob - cov txheej txheem kho kom haum xeeb ua rau muaj kev cuam tshuam loj heev rau fibrotic. Qhov tseem ceeb, kab mob ntsws interstitial thiab pulmonary fibrosis yog cov teeb meem tshwm sim hauv cov kab mob autoimmune, xws li mob caj dab rheumatoid, qhia txog qhov sib txuas ntawm kev tiv thaiv kab mob thiab kho fibrotic.

Yog li ntawd, kev txhim kho ntawm cov qauv preclinical uas raug ntes ob qho tib si tiv thaiv kab mob thiab fibrotic Cheebtsam yog qhov tseem ceeb rau kev tshawb fawb txog kev siv tshuab thiab kev tshuaj ntsuam xyuas.

Prisys Biotechnologies tau tsim ib qho bleomycin -induced pulmonary fibrosis qauv nyob rau hauv cynomolgus liab los ntawm lub hom phiaj intratracheal tswj (ib zaug-lobe los yog multi-lobe xa). Txoj hauv kev no ua rau muaj kev mob ntsws ntev thiab ua tau zoo nrog cov kab mob pathological zoo ib yam li tib neeg IPF, suav nrog kev tsim fibrotic band thiab honeycomb-zoo li kev kho cov qauv. Tus qauv tau ua tiav nyob rau hauvNHP Pharmacologycov kev tshawb fawb ntawm cov neeg sib tw los tiv thaiv- cov neeg ua haujlwm fibrotic, qhia tau tias muaj peev xwm txhais lus muaj zog.

Kev Ntsuas Tus Qauv Ua Ntej: Quantitative CT Imaging thiab Lung Lesion Analysis

Qhov tseeb thiab lub hom phiaj kom muaj nuj nqis ntawm fibrotic lub nra yog qhov tseem ceeb hauv kev txhim kho tshuaj IPF. Siab -kev daws teeb meem suav tomography (CT) ua lub luag haujlwm tseem ceeb hauv kev tsis yog- kev ntsuas kev cuam tshuam ntawm lub ntsws cov qauv thiab kev kis tus kab mob.

Prisys Biotechnologies 'kev soj ntsuam kev tshawb fawb platform yog nruab nrog siab heevClinical Imagingcov tshuab muaj peev xwm ntawm siab - daws teeb meem thoracic scans hauv cov qauv tsiaj loj. Qhov tseem ceeb, lub platform suav nrog kev tshaj tawm tshwj xeeb- ua software, suav nrog CT- raws li kev tshuaj xyuas lub ntsws nodule thiab emphysema quantification cov cuab yeej.

Los ntawm leveraging peb -dimensional (3D) imaging reconstruction technologies, cov kws tshawb fawb muaj peev xwm ua semi-automated los yog tag nrho automated segmentation ntawm cov pa, tshwj xeeb lub ntsws lobes, thiab fibrotic lesions. Qhov no ua rau muaj tseeb volumetric kom muaj nuj nqis ntawm fibrosis thiab longitudinal saib xyuas ntawm tus kab mob kev loj hlob los yog kho cov lus teb.

Piv nrog rau kev soj ntsuam histopathological ib txwm muaj, uas yog qhov kawg ntawm qhov kawg thiab txwv tsis pub muaj nyob hauv qhov sawv cev, CT-raws li 3D imaging tso cai rau txuas ntxiv, tsis yog -invasive, thiab ntau qhov kev ntsuam xyuas ntawm fibrosis dynamics hauv vivo. Qhov no txhim kho cov ntaub ntawv txuas mus ntxiv, txo cov kev sib tshuam - qauv hloov pauv, thiab txhim kho kev txhais lus kho mob.

Teem caij nrog cov chaw kho mob kawg: Kev Ntsuas Pulmonary Function Testing (PFT)

Thaum cov kev ntsuas kev ntsuas muab cov kev nkag siab tseem ceeb rau kev hloov pauv ntawm cov qauv, qhov kawg kev soj ntsuam cuam tshuam ntawm IPF nyob rau hauv qhov kev poob qis ntawm kev ua pa ua pa. Yog li ntawd, cov ntsiab lus ua haujlwm kawg yog qhov tseem ceeb rau kev qhia txog kev kho mob.

Ua ke nrog kev yees duab-raws li kev ntsuam xyuas, Prisys Biotechnologies integrates pulmonary function testing (PFT) rau hauv nws qhov kev ntsuam xyuas preclinical moj khaum. Cynomolgus liab nyob rau hauv longitudinalUa pakev saib xyuas ntawm cov hauv paus ntsiab lus thiab ntau qhov kev tshaj tawm - lub sijhawm induction ntsiab lus.

Qhov tseem ceeb ntawm lub cev tsis muaj zog, suav nrog kev mob ntsws ntsws thiab kev ua raws li pulmonary, tau sau tseg thiab ua kom muaj nuj nqis. Qhov no ua rau lub sijhawm tiag tiag - kev soj ntsuam ntawm kev ua haujlwm tsis zoo thiab rov qab los tom qab kev cuam tshuam kho mob.

Kev sib xyaw ua ke ntawm "quantitative CT imaging" thiab "dynamic pulmonary function assessment" tsim kom muaj kev ntsuam xyuas dav dav uas txuas cov ntsiab lus anatomical thiab physiological endpoints. Ib qho kev sib xyaw ua ke zoo sib xws nrog cov qauv kev sim tshuaj ntsuam xyuas thiab ntxiv dag zog rau kev kwv yees tus nqi ntawm kev tshawb pom preclinical.

Xaus

Kev txhim kho cov kev kho mob zoo rau IPF thiab cov kab mob ntsig txog pulmonary yuav tsum muaj cov qauv ua ntej thiab kev ntsuam xyuas cov txheej txheem nrog kev txhais lus siab. Prisys Biotechnologies hais txog qhov kev xav tau no los ntawm kev lag luam- qib tsiaj loj txhais lub platform uas suav nrog NHP tus qauv kab mob, kev tshuaj ntsuam xyuas CT siab heev, thiab kev ntsuas kev ua haujlwm ntawm lub ntsws ntau.

Qhov kawg no -rau- qhov kawg kev daws teeb meem muab lub hom phiaj, ntau npaum li cas, thiab cov ntaub ntawv tseem ceeb hauv chaw kho mob los txhawb cov kav dej thoob ntiaj teb kev txhim kho tshuaj, thaum kawg pab txhawb kev txhais lus zoo dua los ntawm kev tshawb fawb preclinical mus rau kev kho mob ua tiav.

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Cov lus nug nquag nug (FAQ)

Q: Vim li cas cov tshuaj tsim kho rau Idiopathic Pulmonary Fibrosis (IPF) tshwj xeeb yog qhov nyuaj?

A: IPF yog ib hom kab mob uas muaj feem cuam tshuam nrog kev raug mob epithelial, kho qhov txhab tsis zoo, kev tiv thaiv kab mob, thiab kev kho mob fibrotic. Cov qauv kev kho mob ib txwm muaj-tshwj xeeb tshaj yog cov qauv nas- feem ntau tsis ua kom rov ua tiav qhov kev mob ntev, qhov sib txawv ntawm qhov sib txawv, thiab kev ua haujlwm poob qis hauv tib neeg IPF. Qhov kev sib txawv no txwv qhov kev kwv yees tus nqi ntawm cov ntaub ntawv ua tau zoo ntawm cov ntaub ntawv kho mob thiab ua rau muaj qhov tsis ua haujlwm kho mob siab.

Q: Qhov txiaj ntsig zoo li cas uas tsis yog - tib neeg primate (NHP) qauv muaj nyob rau hauv kev tshawb fawb IPF?

A: NHP qauv, tshwj xeeb tshaj yog cynomolgus liab, muab ze zog rau anatomical, physiological, thiab immunological zoo sib xws rau tib neeg piv rau nas. Qhov no txhim kho qhov kev txhais lus tseem ceeb ntawm kev tshawb pom, tshwj xeeb tshaj yog nyob rau hauv cov kev tshawb fawb txog kev tiv thaiv kab mob thiab lub ntsws ua haujlwm. Lub bleomycin -induced NHP qauv tsim los ntawm Prisys ua rau replication ntawm cov mob ntev, kev loj hlob fibrosis nrog cov yam ntxwv tseem ceeb xws li fibrotic bands thiab honeycomb-zoo li kho.

Q: Yuav ua li cas bleomycin -induced NHP qauv txhim kho kev txhais lus kwv yees?

A: Tsis zoo li tus mob hnyav lossis tus kheej - daws cov qauv nas, NHP qauv txhawb nqa kev txhawb nqa thiab kev loj hlob ntawm fibrosis. Targeted intracheal delivery (ib zaug -lobe lossis multi-lobe) tso cai rau kev tswj hwm induction ntawm cov kab mob hauv zos los yog diffuse, zoo dua li kev soj ntsuam heterogeneity. Qhov no ua rau muaj kev ntsuam xyuas ntau dua ntawm kev ua tau zoo ntawm cov tshuaj, koob tshuaj - teb kev sib raug zoo, thiab kab mob- hloov kho qhov muaj peev xwm.

Q: Vim li cas qhov kev ntsuas CT ntau qhov tseem ceeb hauv IPF kev tshawb fawb ua ntej?

A: Siab- daws teeb meem CT imaging muab ib qho uas tsis yog - ntxeem tau thiab longitudinal txoj kev los ntsuam xyuas lub ntsws qauv thiab lub nra fibrotic. Los ntawm 3D reconstruction thiab segmentation, cov kws tshawb fawb tuaj yeem ntsuas qhov ntim ntawm qhov txhab, saib xyuas cov kab mob kev loj hlob, thiab ntsuas kev kho cov lus teb raws sijhawm. Txoj hauv kev no kov yeej cov kev txwv ntawm ib txwm muaj histopathology, uas yog lub davhlau ya nyob twg thiab tsuas yog muab cov duab thaij duab xwb -raws li cov ntaub ntawv.

Q: Cov peev xwm tshwj xeeb dab tsi uas Prisys muaj hauv CT- raws li kev soj ntsuam lub ntsws?

A: Prisys integrates advanced imaging hardware with dedicated post-processing software, including the lung nodule analysis and emphysema quantification tools. Lub platform txhawb semi-automated thiab automated segmentation ntawm lub ntsws lobes, airways, thiab fibrotic cheeb tsam, ua kom meej volumetric ntsuas thiab feem pua ntawm cov kev hloov pauv hauv kev tshawb fawb longitudinal.