Hnub no yog 30th Ntiaj Teb Alzheimer's Day. Xyoo 1906, German kws kho mob hlwb thiab kws kho mob neuropathologist Alois Alzheimer (1864-1915) tau tshawb pom ib tus kab mob tshwj xeeb neurodegenerative, uas ua rau muaj kev nco tsis zoo, kev txawj ntse poob thiab cov ntaub so ntswg tseem ceeb hauv lub hlwb hloov pauv hauv cov neeg mob. Tus kab mob no tom qab hu ua tus kab mob Alzheimer's incurable (AD).
Daim duab 1. Cov txheej txheem pathological thiab kev coj tus cwj pwm ntawm AD
(Duab qhov chaw: Molecules 2020,25(24),5789; www.nia.nih.gov)
Cov Kev Sib Tw ntawm AD Drug Development
Txhawm rau kho tus kab mob no kho tsis tau, cov kws tshawb fawb tshuaj tau ua haujlwm tsis tu ncua los tsim cov tshuaj zoo lossis kev kho mob rau cov tsos mob AD. Txawm li cas los xij, kev kho mob tam sim no ntawm AD tsuas tuaj yeem ncua kev txhim kho cov tsos mob ntawm tus kab mob mus rau qee qhov, thiab tseem muaj txoj hauv kev ntev mus ua ntej kev kho mob tiag tiag.
Biomarkers thiab Pathogenic mechanisms
Xav txog cov teeb meem tam sim no hauv AD kev tsim kho tshuaj thiab cov kev txwv ntawm cov tshuaj uas twb muaj lawm rau cov neeg mob AD hnyav, cov kws tshawb fawb paub tias qhov kev loj hlob ntawm AD yog qhov hloov tsis tau, uas txhais tau hais tias kev kuaj mob ntxov yog qhov tseem ceeb heev rau kev kho AD tam sim no.
Daim duab 2. Hom biomarkers rau kev kuaj mob AD hauv cov lus qhia
Cov lus qhia tshiab tshaj tawm qhia peb hom biomarkers hauv AD: core, nonspecific thiab non-AD comorbidity biomarkers.
- Core biomarkers qhia txog kev sib sau ntawm amyloid-beta (A) thiab tau cov proteins, uas yog cov yam ntxwv tseem ceeb ntawm AD. Lawv suav nrog A 42/40 thiab p-Tau qib hauv cerebrospinal kua lossis ntshav ntshav, thiab amyloid-PET thiab tau-PET scans.
- Nonspecific biomarkers qhia txog cov neurodegeneration thiab mob tshwm sim los ntawm AD. Lawv suav nrog NFL thiab GFAP qib hauv cerebrospinal kua lossis ntshav ntshav, thiab cov qauv MRI thiab FDG-PET scans.
- Tsis yog -AD comorbidity biomarkers qhia txog lwm yam mob uas tuaj yeem nrog AD, xws li vascular dementia lossis Lewy lub cev dementia. Lawv suav nrog cerebral infarction thiab -synuclein qib hauv cov kua cerebrospinal.
- Qhov kev lees paub dav dav tshaj plaws ntawm cov txheej txheem pathogenic yog tias A thiab tau cov proteins tsim cov kab mob sib txawv uas cuam tshuam rau kev ua haujlwm thiab kev ciaj sia ntawm neurons thiab synapses. Kev hloov caj ces hauv APP, PSEN1, PSEN2 thiab MAPT cov noob tuaj yeem ua rau muaj kev pheej hmoo ntawm AD los ntawm kev cuam tshuam rau kev tsim lossis tshem tawm ntawm A thiab tau. Lwm yam, xws li o, oxidative kev nyuaj siab, neurotransmitter imbalance thiab synaptic dysfunction, kuj yuav ua rau AD pathogenesis.
Tsis yog - tib neeg primates hauv AD tshuaj tsim kho
Tsis yog- tib neeg primates muaj qhov zoo sib xws ntau dua hauv cov qauv neural system thiab ua haujlwm rau tib neeg, thiab tuaj yeem kov yeej cov kev txwv ntawm kev tshawb fawb soj ntsuam xws li tsis tuaj yeem paub lub hlwb lub cev ntawm cov neeg mob thiab tsis tuaj yeem soj ntsuam cov kev hloov pauv ntawm lub paj hlwb thaum lub sij hawm pathological. Yog li ntawd, kev tshawb fawb ntawm cov kab mob loj tsiaj muaj irreplaceable guiding lub luag hauj lwm rau cov kev kho mob thiab cov tshuaj ntawm cov kab mob neurodegenerative, thiab pab kom meej lub etiology, pathogenesis, tshuaj ua tau zoo thiab pharmacological teebmeem, thiab muaj zoo heev daim ntawv thov nqi nyob rau hauv txoj kev loj hlob ntawm txoj kev kho tshiab thiab tshuaj.
Hauv kev teb rau cov kev cov nyom no, AD kev tsim kho tshuaj yuav tsum muaj kev qhia dav dav nrog cov kws tshuaj thiab kev tshawb fawb txog kev ua haujlwm kho mob. Lub CNS platform ntawm In Vivo Pharmacology Department of Biology Business Unit ntawm Prisys Biotechnology tau cog lus rau preclinical tsiaj pharmacology thiab ua haujlwm tau zoo rau ntau yam kab mob hauv nruab nrab paj hlwb, suav nrog AD, PD, kev ntxhov siab, kev mob thiab lwm yam. Kev nkag siab tob txog kev tsim qauv tsiaj thiab kev txhim kho tus qauv kab mob yog qhov tseem ceeb rau kev sim tsim, thiab tuaj yeem siv cov qauv no los kawm cov kab mob thiab kev tsim tshuaj tshiab.
Tsis yog- tib neeg cov qauv tsim rau kev tshawb fawb AD
Piv nrog rau cov qauv nas, tsis yog- tib neeg cov qauv primate muaj qhov zoo dua hauv kev kawm cov qauv neural thiab kev ua haujlwm, cov kab mob kev loj hlob thiab biomarkers ntawm AD. Prisys Biotechnology muaj lub platform tshwj xeeb rau kev tshawb fawb tsis yog - tib neeg kev tshawb fawb primate, uas tuaj yeem muab kev nkag siab zoo rau AD kev tsim kho tshuaj thiab kev siv tshuaj kho mob.
Prisys Biotechnology yog ib lub tuam txhab hauv kev tshawb fawb tsis yog - human primate (NHP) rau cov kab mob neurological:
Prisys Biotechnology muaj lub xeev - ntawm - - cov cuab yeej kos duab rau kev kos duab, kev phais, kev txheeb xyuas tus cwj pwm, thiab kev kuaj mob. Peb tuaj yeem ua cov txheej txheem qib siab xws li kev sib nqus resonance imaging (MRI), positron emission tomography (PET), electroencephalography (EEG), sib sib zog nqus hlwb stimulation (DBS), thiab microdialysis.
Prisys Biotechnology tau tsim cov txheej txheem tshiab thiab meej rau kev ua haujlwm ntawm lub paj hlwb, kev kaw suab hluav taws xob, thiab hauv - vitro diagnostics. Peb tuaj yeem tswj xyuas lub hlwb kev ua haujlwm ntawm NHPs nrog qhov tseeb thiab qhov tshwj xeeb, thiab ntsuas qhov kev hloov pauv hauv cov cim qhia ntawm neural thiab biomarkers.
Prisys Biotechnology tau tsim cov qauv sib txawv thiab txhim khu kev qha rau mob neuropathic mob, Parkinson's kab mob, kev nyuaj siab, thiab mob stroke. Peb tuaj yeem txhawb nqa thiab ntsuas cov kab mob neurological no hauv NHPs nrog qhov zoo sib xws thiab muaj feem cuam tshuam rau tib neeg cov xwm txheej thiab cov txiaj ntsig.
Prisys Biotechnology yog ib tug pioneer hauv NHP kev tshawb fawb rau cov kab mob neurological. Peb muaj lub platform tshwj xeeb uas tuaj yeem muab kev nkag siab zoo rau kev txhim kho tshuaj thiab kev siv tshuaj kho mob. Yog tias koj xav kawm ntxiv txog Prisys Biotechnology, koj tuaj yeem mus xyuas www.prisysbiotech.com lossis tiv tauj peb ntawm bd@prisysbiotech.com.
