Prisys Biotechnologies yog nyob rau hauv pem hauv ntej ntawm kev nce qib ntawm kev tshawb fawb tshuaj thiab kev loj hlob los ntawm peb lub tswv yim tshiab thiab ua tiav tsis yog -tib neeg primate (NHP) qauv rau kev tiv thaiv kab mob thiab kab mob. Nrog lub zog thiab ruaj khov preclinical platform, peb tshwj xeeb hauv kev hloov tshuaj R&D rau ntau yam kev tiv thaiv kab mob thiab mob (I&I), tsom rau kev mob caj dab rheumatoid (RA), ntau yam sclerosis (MS), thiab kab mob plab plob tsis so tswj (IBD).
Vim li cas thiaj siv NHP rau Kuv & Kuv Tshawb Fawb?
Siv NHP cov qauv rau kev tshawb fawb I&I muab ntau qhov zoo, suav nrog kev muaj peev xwm los kawm txog tib neeg biomarkers, cov ntsiab lus kho mob, thiab cov tshuaj biosamples ntev, kom ntseeg tau tias kev txhais cov tshuaj ntau npaum li cas thiab muaj txiaj ntsig zoo. Cov qauv no tseem muaj kev nyab xeeb dav dav- kev tshuaj xyuas tshuaj thiab tshuaj xyuas kaum cov tshuaj tiv thaiv kab mob tseem ceeb (Neutrophils, Basophils, B Cells, CD8+ T Cells, CD4+ T Cells, CD4+/CD8+ T Cells, pDCs, Monocytes, Classicalytes. Kev tshawb fawb los ntawm Nolan GP et al. (2022) qhia txog qhov ua tau zoo ntawm NHP cov qauv, thaum lub CT scan ntawm lub ntsws mob ntsws nyob rau hauv NHP qauv ntawm mob ntsws, kuaj pom nyob rau hauv tib neeg CT ib ntus, lees paub cov ntaub ntawv txhais lus (PRISYS, unpublished data, 2023).
Comprehensive I & Kuv Models
Peb cov qauv NHP tau tsim kho kom zoo dua qub rau qhov nyuaj ntawm tib neeg lub cev tiv thaiv kab mob thiab cov kab mob inflammatory. Cov qauv Prisys 'I&I' suav nrog ntau yam kab mob- tshwj xeeb thiab cov khoom nruab nrog- kev tshawb fawb tshwj xeeb o, muab cov cuab yeej tseem ceeb rau cov kws tshawb fawb txhawm rau nkag siab thiab tawm tsam cov xwm txheej no.
Rheumatoid mob caj dab (RA): Peb tus qauv rheumatoid mob caj dab (RA) rov ua dua cov yam ntxwv tseem ceeb ntawm tib neeg RA. Qhov no suav nrog kev sib koom ua ke ntawm cov kab noj hniav, kev poob ntawm cov phaj loj, kev puas tsuaj rau pob txha mos thiab meniscus, thiab pob txha yaig. Cov yam ntxwv no ua rau peb tus qauv muaj txiaj ntsig zoo rau kev kawm txog tus kab mob kev loj hlob thiab ntsuas qhov ua tau zoo ntawm cov tshuaj kho tshiab.
Psoriasis Model:Peb tus qauv psoriasis zoo rov ua dua cov kev tshawb pom pom hauv tib neeg psoriasis. Tom qab 14-hnub IMQ kev sib tw, daim tawv nqaij nthuav tawm ntau yam tseem ceeb: cov ntaub so ntswg necrotic sab nraum lub epidermis, tsis sib npaug ntawm cov epidermis tuab, keratosis hauv zos tsis tiav, thiab txo qis hauv collagen muaj pes tsawg leeg thoob plaws lub epidermis thiab dermis. Tsis tas li ntawd, muaj qhov tseem ceeb lymphocyte infiltration, mirroring inflammatory teb pom nyob rau hauv tib neeg psoriasis. Cov qauv no yog qhov muaj txiaj ntsig zoo rau kev kawm txog pathophysiology ntawm psoriasis thiab tshuaj xyuas cov kev pabcuam khomob.
Ntau Sclerosis (MS): Peb cov qauv MS ua rau cov kab mob inflammatory demyelination tus yam ntxwv ntawm tus kab mob, ua kom yooj yim rau kev ntsuam xyuas cov kev kho mob tshiab tsom rau cov kab mob neuroinflammation thiab neuroprotection.
Inflammatory Bowel Disease (IBD): Peb cov qauv IBD tso cai rau kev kawm txog kev mob plab hnyuv, qhov tseem ceeb rau kev tsim kho tshiab los kho Crohn tus kab mob thiab mob plab hnyuv.
Prisys Biotechnologies muaj ib qho kev qhia dav dav ntawm NHP qauv rau ntau yam kab mob tiv thaiv kab mob thiab kab mob. Cov no suav nrog cov qauv rau cov mob autoimmune xws liHom I Diabetes, neuroinflammation hauv Ntau Sclerosis, thiab neurodegeneration hauv Parkinson's Disease. Peb cov qauv inflammatory npogInflammatory Bowel Disease, Pruritus, Endotoxemia, thiab o ntawm lub ntsws, daim siab, thiab lub raum cov ntaub so ntswg. Peb kuj tshwj xeeb hauv cov qauv rau cov kab mob BSL-2 thiab kev tsis haum tshuaj xws liAsthma, Atopic Dermatitis, thiab kev ua xua. Tsis tas li ntawd, peb cov qauv txhawb kev tshawb fawb txog kev tiv thaiv kab mob tsom rauT-cell- cov lus teb nyob ntawm, ncua -hom hypersensitivity, thiab kev tiv thaiv kab mob. Peb muab kev sib koom ua ke- cov phiaj xwm txhim kho rau cov xwm txheej xws li Sjögren's syndrome, Systemic Lupus Erythematosus, thiabIgA nephropathy. Thaum kawg, peb tus qauv Myasthenia Gravis muab kev nkag siab rau cov kab mob autoimmune neuromuscular.
Txhawb Kev Siv Tshuaj Ntau Yam
Prisys Biotechnologies ua tau zoo hauv kev txhawb nqa ntau yam kev siv tshuaj, nrog rau kev paub dhau los hauv kev hloov pauv ntawm cov molecules me mus rau biologics. Peb cov ntaub ntawv teev tseg suav nrog kev ntsuas ua tiav ntawm cov tshuaj tiv thaiv kab mob, tshuaj kho noob, thiab lwm yam kev kho tshiab. Peb cov kws tshaj lij ua kom ntseeg tau tias koj cov txheej txheem kev txhim kho tshuaj tau txais kev txhawb nqa los ntawm cov ntaub ntawv pov thawj txhim khu kev qha, txhim kho qhov ua tau zoo ntawm kev kho mob.
Clinical Transformation Peev xwm
Txhawm rau pab txhawb kev txhais lus kho mob ntawm koj qhov kev tshawb fawb, peb muab kev hloov pauv hauv vivo imaging thiab bio-sampling cov phiaj xwm. Cov peev txheej no tso cai rau kev taug qab qhov tseeb ntawm kev tiv thaiv kab mob thiab mob ntev thiab hloov pauv kab mob, muab kev nkag siab zoo txog kev kho mob cuam tshuam rau lub sijhawm.
Advanced Immunology Assay
Peb cov tshuaj tiv thaiv kab mob siab tshaj plaws rau NHPs suav nrog cov ntshav immunoglobulin (IG) cov ntaub ntawv, cov kab mob tiv thaiv kab mob, thiab kev tshuaj xyuas cytokine. Cov kev ntsuam xyuas no yog qhov tseem ceeb rau kev ntsuam xyuas cov lus teb tiv thaiv kab mob thiab kev ua tau zoo ntawm kev kho immunomodulatory, kom ntseeg tau tias koj tau txais cov ntaub ntawv ntxaws thiab ua tau zoo rau koj qhov kev tshawb fawb.
Koom tes nrog Prisys rau Txiav -Edge Research
Los ntawm kev koom tes nrog Prisys Biotechnologies, koj tau txais kev nkag mus rau lub xeev - ntawm - - art preclinical platform uas tuaj yeem ua rau koj cov kev tshawb fawb txog kev tiv thaiv kab mob thiab kab mob. Peb pab neeg mob siab rau npaj txhij los koom tes nrog koj, muab cov kev txawj ntse thiab cov peev txheej tsim nyog los tsav koj cov haujlwm mus tom ntej. Txhawm rau kawm paub ntau ntxiv txog peb lub platform I & I thiab nws tuaj yeem pab tau koj li kev tshawb fawb li cas, thov nrhiav peb cov ntaub ntawv piav qhia ntxaws ntxaws. Yog xav paub ntxiv txog peb cov qauv NHP lossis npaj ib qho kev nthuav qhia, thov hu rau peb. Peb tos ntsoov yuav tham txog yuav ua li cas Prisys tuaj yeem pab txhawb koj cov tshuaj R & D hloov pauv thiab pab koj txoj kev taug mus rau cov kev daws teeb meem tshiab.
