Cov kab mob Oncolytic (OVs) yog ib chav kawm kho mob qog noj ntshav uas tau xaiv kis thiab rhuav tshem cov qog hlwb thaum txhawb kev tiv thaiv - qog lub cev tiv thaiv kab mob. Vim tias OVs yog cov khoom siv tshuaj lom neeg kis kab mob, lawv qhov kev tshuaj ntsuam xyuas ua ntej sib txawv ntawm cov tshuaj tiv thaiv kab mob ib txwm muaj, xav tau kev ntsuam xyuas dav dav ntawm cov kab mob ruaj khov, biodistribution, pharmacokinetics, shedding, thiab kev nyab xeeb.
Kev vam meej OV kev loj hlob nyob ntawm kev xaiv cov kab mob uas tsim nyog, ua kom muaj kev ruaj ntseg ntawm genome tom qab kev hloov kho caj ces, thiab xaiv cov qauv qog uas muaj feem cuam tshuam txog kev kis tus kab mob hauv vivo. Cov kev tshawb fawb ua ntej yuav tsum tau soj ntsuam cov kev tswj hwm sib txawv, kev faib cov ntaub so ntswg, kev pheej hmoo ntawm tus kab mob, thiab cov lus teb tiv thaiv kab mob, suav nrog kev cuam tshuam ntawm ua ntej -cov tshuaj tiv thaiv kab mob uas twb muaj lawm ntawm kev kho mob.
Ib lub tswv yim zoo preclinical integrates efficiency, pharmacology, thiab biosafety ntsuam xyuas los txhawb kev kho mob txhais lus. Nrog cov kws tshaj lij hauv kev xaiv tsiaj txhu, biodistribution, PK tsom xam, thiab tshuaj kho tus kab mob oncolytic, tshwj xeeb CROs tuaj yeem pab tsim kom muaj - cov ntaub ntawv zoo uas ua rau kom muaj kev nyab xeeb thiab muaj txiaj ntsig zoo ntawm kev kho tus kab mob oncolytic.
