Ntawm -Thov Webinar|Tus Choj Precision: MRI-CED thiab txhais tau NHP qauv rau CNS Kev xa tshuaj
📅Original Broadcast
Executive Summary
Kev xa cov tshuaj kho kom raug rau cov cheeb tsam tshwj xeeb ntawm lub hlwb tseem yog ib qho kev sib tw hauv nruab nrab paj hlwb (CNS) kev txhim kho tshuaj. Cov kev txwv cuam tshuam nrog ntshav- hlwb teeb meem (BBB), nrog rau cov kev txwv hauv kev txheeb xyuas lub hom phiaj kev koom tes, ua rau muaj kev tsis paub meej thaum lub sij hawm kho mob txhais lus.
Qhov kev sib tham no qhia txog kev sib koom ua ke ua keintraoperative MRI (iMRI) -kev taw qhianrogConvection -Kev xa khoom zoo (CED)hauvtsis yog-neeg primate (NHP) qauv. Qhov kev sib koom ua ke no ua rau lub sijhawm tiag tiag - pom kev pom thiab tswj kev tswj hwm intracranial, tsim kom muaj kev kwv yees ntau dua rau siab - kev kho mob nyuaj.
Lub Hom Phiaj Kawm Txuj Ci tseem ceeb
Tshawb nrhiav seb qhov kev sib raug zoo ntawm kev ua haujlwm hauv tsev kho mob thiab chaw kho mob li cas txhawb kev txiav txim siab paub ntau ntxiv- ua hauv CNS kev txhim kho tshuaj, tsom mus rau:
- Target Verification:Hais txog cov teeb meem hauv paus hauv CNS kev xa tshuaj thiab biodistribution.
- iMRI-Cov txheej txheem qhia:Kev sib piv kev pom rau hauv MRI-qhia vs. MRI- txheeb xyuas cov txheej txheem intracranial.
- CED Cov Cai:Mechanics thiab daim ntawv thov ntawm Convection-Txoj kev xa khoom zoo rau kev txhim kho lub paj hlwb parenchymal.
- Precision Navigation:Kev sib koom ua ke ntawm cov txheej txheem navigation rau kev npaj trajectory thiab tiag - saib xyuas lub sijhawm.
- Kev txhais lus txuas ntxiv:Cov tswv yim los txhim kho kev hloov pauv ntawm cov noob thiab kev kho ntawm tes los ntawm cov theem preclinical mus rau kev sim tshuaj.
Cov Neeg Hais Lus Zoo
David S. Wong
BD Manager, Asia Pacific, ClearPoint Neuro
David Wong tau ua haujlwm nrog Biologics & Drug Delivery Team ntawm ClearPoint Neuro rau 4 xyoo, tshwj xeeb hauv kev sim tshuaj thiab kev tswj xyuas cov haujlwm thoob plaws Asia, Oceania, thiab North America. Nrog ze li ntawm 20-xyoo txoj haujlwm hauv cov cuab yeej kho mob thiab tshuaj, nws tau txais Master's hauv Biotechnology los ntawm Johns Hopkins University.
James Song
General Manager, PRISYS Biotech
James Song leverages 20 xyoo ntawm kev txawj ntse hauv NHP pharmacology thiab kab mob qauv. Nws tshwj xeeb hauv kev tshawb nrhiav qhov nyuaj ntawm cov tshuaj txhais lus thiab tau coj txoj kev loj hlob ntawm Prisys 'sophisticated laboratory infrastructure thiab tshwj xeeb.NHP qauvtxhawm rau txuas qhov sib txawv ntawm chav kuaj thiab chaw kho mob.
Nkag mus rau Lub Chaw Pabcuam
Koom nrog cov kws tshaj lij thoob ntiaj teb hauv preclinical pharmacology, neuroscience, thiab kev kho noob kom tau txais kev nkag siab zoo ntawm cov txheej txheem tam sim no rau CNS kev xa tshuaj.
Passcode: T09TK?Zb
Nco tseg: Kev tso npe yuav tsum tau nkag mus rau cov ntaubntawv povthawj siv thiab cov txuj ci Lite-version ntawm kev nthuav qhia lawj.
Xav nug ntxiv
Txhawm rau teem caij ua raws li cov txheej txheem ua raws- nce lossis sib tham txog qhov yuav tsum tau ua ntawm qhov project, thov hu rau peb pab neeg ntawm:
Email: bd@prisysbiotech.com
FAQ
Q: Dab tsi yog cov txiaj ntsig ntawm kev siv iMRI- coj CED hauv CNS xa tshuaj?
A: iMRI-coj CED tso cai rau tiag tiag- lub sijhawm pom kev ntawm cov txheej txheem infusion, kom ntseeg tau tias cov kev kho mob mus txog thaj tsam lub hom phiaj hauv lub hlwb thaum saib xyuas kev faib tawm thiab txo qis - cov phiaj xwm cuam tshuam.
Q: Vim li cas NHP qauv tseem ceeb rau CNS tshuaj txhais lus?
A: Tsis yog -tib neeg primates (NHPs) muaj lub hlwb cov qauv thiab cov yam ntxwv neuroanatomical zoo ib yam li tib neeg, ua rau lawv tus qauv kub rau kev kuaj mob intracranial thiab kwv yees qhov tshwm sim ntawm kev kho mob rau cov noob thiab kev kho ntawm tes.
Q: Convection li cas -Kev xa khoom zoo (CED) txawv ntawm kev txhaj tshuaj li cas?
A: Tsis zoo li qhov yooj yim diffusion, CED siv lub siab gradient kom ua tiav cov kev faib tawm ntawm kev kho mob thoob plaws ntau qhov loj ntawm lub paj hlwb parenchyma, kov yeej cov kev txwv ntawm cov ntshav - hlwb barrier.
