NHP Mob Mob Qauv: Nraj Ua kom muaj kev sib zog ua kom muaj kev txhim kho tshuaj ntawm prisys biotech - prisys cov xwm txheej

Qhov mob yog qhov teeb meem thoob ntiaj teb kev kub ntxhov, ua rau muaj kev mob plawv, thiab mob qog nqaij hlav, thiab mob ntshav qab zib, thiab ntshav qab zib ne3}}

Cov kev ua yeeb yam tam sim no, xws li opioids thiab nonsteroidal anti-inticical txoj kev xav tau thiab qhov kev pheej hmoo mob siab rau kev tsim kho cov kev ua lag luam tseem ceeb thiab kev pheej hmoo ua haujlwm rau kev ua lag luam tseem ceeb thiab kev pheej hmoo ua haujlwm rau kev tsim kho kom zoo dua qub

Proposed mechanisms of the role of Nav1.7 and Nav1.8 in the pathophysiology of neuropathic pain and inflammatory pain. — Thov kom cov txheej txheem ntawm lub luag haujlwm ntawm NA_v1.7 thiab na_v1 {. 8 nyob rau hauv lub evophysiology ntawm kev mob neuropathic thiab mob mob.
doi {.} org / 10.1177 / 174480691919858801

Qhov nce ntawm cov ntses sodium raws li cov ntsiab lus tseem ceeb

Voltage-gated sodium (Nav) Raws, tseem ceeb rau hluav taws xob hauv kev ua kom zoo nkauj rau cov khoom lag luam neuring, NAV1}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} Tshwj xeeb, cov tib neeg uas muaj kev sib hloov ntawm NAV1.7's congenitally tsis tuaj yeem hnov mob, ua rau muaj kev sib zog ua yeeb yam.

Tsis ntev los no Breakthroughs muaj kev sib cuag no . NAVE 1 {9 (SUZE} NAV1.8 inhibitor qhov chaw, underscores lub peev xwm loj ntawm chav kawm lub hom phiaj no.

Txawm li cas los xij, kev sib txuas lus tseem ceeb tau tshwm sim: ntau cov me me thaiv cov neeg ua ntej ntawm cov tshuaj twv ua ntej rau cov tshuaj no.Cov Lus Qhia Tsis Yog Tib Neeg (NHPs), nrog lawv cov caj ces siab dua rau tib neeg, muab cov kev ntsuas kom zoo dua thiab muaj cov kev sib raug zoo rau hauv-vivo ntsuas {}}Khiys Biotechtxoj kev sib zog ua kom zoo dua kom muab cov ntaub ntawv ua kom ruaj khov thiab twv ua ntej cov ntaub ntawv .

Prisys biotech txoj kev siv tau suite ntawm NHP mob tus qauv

Khiys Biotechtau tsim cov portfolio ntawm kev tsim kho tshiab thiab siv tau Cynomolgus cov qauv kev kho mob liab, muab cov kev daws teeb meem rau kev ua kom zoo rau kev ua kom zoo nkauj.

Capsaicin induced vasodilation responses Laser Speckle Contrast Imaging (LSCI) — Capsaicin inducts vasodilation teb teb
• Laser Speckle compast kev ntsuam xyuas (LSCI)

Txau Mob Qauv

Capsaicin-Induced Mob Qauv:Tus qauv no siv Intradermal capsaicin txhaj rau kev ua kom muaj kev ntsuas lub laserBold Ua Haujlwm MRI (FMRI), which detects pain-related activity in brain regions like the insula, primary motor cortex (M1), and somatosensory cortex (S1).
Formalin-induced mob tus qauv:Ua raws li kev txhaj tshuaj tiv thaiv kev ua kom zoo nkauj siv peb cov phiaj xwm 3D pom kev ua haujlwm zoo li tus cwj pwm tshwj xeeb ntawm cov xeeb ntxwv

Mob neuropathicMob Qauv Mob

Ib nrab sciatic leeg ligation (PSNL) qauv:Tus qauv no simulates muaj mob neuropathic . Kev ntsuas suav suav nrog:
Mechanical & thermal hyporsensitivity:Qhov mob txo qis (Hyperalesia) yog pom nyob rau hauv thaum ntxov tom qab theem (<10 days), which can evolve to tolerance at later stages.
Txias gradicynia:Txhawb nqa hypersensitivity rau cov cua txias ({0 / 10/15 degree) yog xwm yeem saib {}
SOOSSE KERTATION VELOCITY (SCV):Kev ntsuas tom qab kev soj ntsuam pom tseeb ntawm cov leeg hlab ntsha
3D Kev Coj Tus cwj pwm:Kev nce siab hauv kev ua yeeb yam uas dai rau kev dai rau ntawm lub sijhawm thaum ntxov ({{1} {{{2} {2}.

Qauv hauv Kev Loj Hlob

Khiys Biotechyog txuas ntxiv nthuav dav nws lub peev xwm nrog cov qauv tshiab, suav nrog:

Spinin kerve ligation (SNL) rau kev mob neuropathic .
Cov tshuaj kho mob-inducer peripheral neuropathy (licn), xws li oxaliplatin-mob mob.
Cov qauv no tsom rau kev ntsuam xyuas cov kab mob tshwm sim, tshuab / thermal hyperalgesia, thiab txias tag nrho {}}

Cov thev naus laus zis rau kev ntsuas mob kom mob

Khiys Biotechkev sib xyaw ua ke-ntug thev naus laus zis kom txav mus dhau kev ntsuas cov ncauj lus thiab muab cov hom phiaj, cov ntaub ntawv ntau.

Ai-powered coj tus cwj pwm:Peb cov tswv yim tswv yim ™ kev siv cov koob yees duab siab rau cov tsiaj txhu ua kom pom tseeb, txhawb kev ua haujlwm zoo li kev coj ua, kev nyab xeeb, thiab tus kab mob tus kab mob {}}

Kawm Tau:Peb muab cov qib siab kawg, suav nrog:

Kev kuaj mob mob:Txawm tias muaj nuj nqis rau lub sijhawm nyob rau hauv kev mob tus cwj pwm kev mob .
Tail-flick sim:Kev Tshuaj Ntsuam Xyuas Kev Ntsuas Hluav Taws Xob Hluav Taws Xob Hluav Taws Xob .
Qhov chaw ntsuas nyiam:Kev tshuaj xyuas qhov mob los ntawm kev saib xyuas tus tsiaj nyiam rau cov chaw sib txawv .
Pupillometry:Ntsuas cov tub ntxhais kawm cov lus teb rau kev txhawb nqa tsis muaj txiaj ntsig .
Sib sib zog nqus hlwb EEG:Kuaj pom kev ua kom mob-rau cov lus teb (~ 8Hz thiab ~ 80hz rau mob hnyav) thiab hloov pauv lub zog ua haujlwm cuam tshuam nrog mob ntev {}}
Precision CNS Kev Xa Khoom:Peb lub sijhawmStralaOperative MRI (RT-IMRI Kev Taw Qhia Kev Taw Qhiaua kom muaj kev kub siab, kev nyab xeeb ntawm kev kho rau cov paj hlwb, uas yog qhov kev kho tshiab rau cov kev kho mob lub hauv paus kev.

Bold fMRI of Pain model — Bold Fmri ntawm Cov Qauv Mob

Xaus: Koj tus khub rau kev nce nrawm

Los ntawm kev tsom cov sodium raws thiab lwm yam tshiab ntawm cov kev sib cais tuav cov lus cog tseg ntawm kev hloov pauv kev tswj hwm {}}Khiys Biotechsawv ntawm qhov ua ntej ntawm qhov kev siv zog no, muab kev sim siv tau thiab siv tau cov tshuaj ntsuam xyuas tsis meej rau kev ntsuas tshuaj tsis meej rau kev ntsuas tshuajNHP Mob Qauv, ua ke nrog kev tshaj lij, lub hom phiaj kev ntsuam xyuas cov pov thawj tsim nyog rau thaum ntxov kev soj ntsuam kev ua haujlwm zoo rau kev ua haujlwm.

Tus khub nrogKhiys Biotechkom muaj kev pheej hmoo rau koj cov raj xa dej, tsim cov ntaub ntawv muaj feem cuam tshuam, thiab ua kom muaj kev kho kom zoo ntawm kev kho mob qhov mob {}}