Tsis ntev los no, eBioMedicine, ib phau ntawv xov xwm hauv Tsev Neeg Lancet, tau luam tawm txoj kev tshawb fawb hu ua "Hloov kho hTERT kho kom txo qis siab tshaj - ua rau lub plawv tsis ua haujlwm."Kev tshawb fawb piav qhia txog kev kho noob tshiab, JV101, uas ua rau kev qhia ntawm kev hloov pauv tib neeg telomerase thim rov qab transcriptase (modhTERT). Los ntawm kev kho telomere, cov kev kho tau pom tias txhim kho mitochondrial muaj nuj nqi, txo cov mob ntev, thiab thaum kawg txo qis kev mob plawv tsis ua hauj lwm.
Raws li ib tug preclinicaltsis yog-tus qauv kab mob ntawm tib neegkev tshawb fawb tus khub, Prisys Biotechnologies muab siab -zoo cynomolgus liab lub plawv tsis ua hauj lwm cov ntaub so ntswg cov qauv uas txhawb kev siv tau ntawm cov txheej txheem tseem ceeb pathological nyob rau hauv ib tug translationally cuam tshuam loj- qauv tsiaj. Txoj kev tshawb no qhia txog lub luag haujlwm tseem ceeb ntawm NHP qauv hauv kev sib txuas cov kev tshawb pom thiab kev txhim kho kho mob.
Kev lees paub qhov txuas ntawm Telomere Dysfunction thiab Lub plawv tsis ua haujlwm hauv NHPs
Telomere shortening tau ntev tau cuam tshuam nrog kev laus thiab kab mob plawv. Txawm li cas los xij, cov pov thawj ncaj qha txuas telomere tsis ua haujlwm rau lub plawv tsis ua haujlwm nyob rau hauv cov tsiaj nyeg siab dua tseem txwv.
![Paraffinembedded NHP cardiac samples were used for telomere Q-FISH quantification of CMs. NHP CMs (cardiac Troponin-T [green]) were stained for telomere (red) and for nuclear DAPI (blue) in heart failure and control cardiac tissue sections. Masson's trichrome staining was performed to confirm cardiac fibrosis in failing NHP hearts (healthy NHP, n = 3; HF NHP, n = 3).](/uploads/39406/news/p202606021422106ad66.png?size=691x0 "Paraffinembedded NHP cardiac samples were used for telomere Q-FISH quantification of CMs. NHP CMs (cardiac Troponin-T [green]) were stained for telomere (red) and for nuclear DAPI (blue) in heart failure and control cardiac tissue sections. Masson's trichrome staining was performed to confirm cardiac fibrosis in failing NHP hearts (healthy NHP, n = 3; HF NHP, n = 3).")
stained rau telomere (liab) thiab rau nuclear DAPI (xiav) nyob rau hauv lub plawv tsis ua hauj lwm thiab tswj cov kab mob plawv. Masson's trichrome staining yog
ua kom paub tseeb tias mob plawv fibrosis hauv NHP lub siab tsis zoo (NHP noj qab haus huv, n=3; HF NHP, n=3).
Txhawm rau ntxiv dag zog rau kev txhais lus muaj feem cuam tshuam, cov kws tshawb nrhiav tau koom nrog cov qauv tsis yog- tib neeg lub plawv tsis ua haujlwm rau hauv lawv cov tswv yim tshawb fawb. Siv cov ntaub so ntswg uas muab los ntawm Prisys Biotechnologies, pab pawg tau ua cov kev tshuaj ntsuam xyuas uas qhia txog ntau yam kev mob plawv, suav nrog:
- Kev txo qis hauv cardiomyocyte telomere signals;
- Nce myocardial fibrosis;
- Kev nthuav qhia siab ntawm B-hom natriuretic peptide (BNP);
- Kev sib raug zoo ntawm telomere kev ncaj ncees thiab lub plawv tsis ua haujlwm, suav nrog sab laug ventricular ejection feem (LVEF).
Cov kev tshawb pom no tau ua pov thawj tias telomere attrition muaj feem cuam tshuam nrog kev mob plawv tsis ua hauj lwm hauv cov neeg uas tsis yog - tib neeg primates, tsom iav tsom hauv tib neeg cov neeg mob. Cov txiaj ntsig tau muab kev txhawb nqa tseem ceeb rau cov txheej txheem kho mob tom qab JV101 thiab ntxiv dag zog rau tus nqi txhais lus ntawm NHP cov qauv hlab plawv.
Vim li cas ho tsis yog -Human Primate Models Matter in Cardiovascular Translational Research
Cov qauv nas yog qhov tseem ceeb rau kev tshawb fawb thaum ntxov -txoj kev siv tshuab, tab sis lawv lub peev xwm los kwv yees cov txiaj ntsig kev kho mob feem ntau raug txwv los ntawm qhov sib txawv ntawm cov hlab plawv lub cev, lub cev nqaij daim tawv, thiab kev kis kab mob.
Tsis yog- tib neeg primates muaj ntau qhov zoo rau kev tshawb fawb txog kev mob plawv:
- Lub plawv anatomy thiab coronary ncig cov qauv zoo ib yam li cov tib neeg;
- Electrophysiological yam ntxwv tseem ceeb dua kev kho mob;
- Kab mob kev loj hlob zoo dua qhia txog tib neeg cov hlab plawv pathology;
- Cov lus teb tiv thaiv kab mob yog qhov kev kwv yees ntau dua rau kev ntsuam xyuas cov kev kho mob siab tshaj xws li cov noob caj noob ces thiab kev kho ntawm tes.
Raws li qhov tshwm sim, NHP qauv tau dhau los ua tus choj txhais lus tseem ceeb rau kev tsim kho cov noob caj noob ces tshiab, RNA-cov tshuaj raws li, thiab cov tshuaj kho dua tshiab tau coj los tsom rau cov kab mob plawv.
Kev siv tau zoo ntawm NHP cov ntaub so ntswg hauv txoj kev tshawb no ntxiv qhia txog tus nqi siab ntawm -cov qauv kab mob kev ncaj ncees hauv kev txhawb nqa kev txiav txim siab txhais lus- ua thiab de- pheej hmoo rau kev txhim kho kho mob.
Prisys Biotechnologies 'NHP Cardiovascular and Disease Model Platform
Prisys Biotechnologies tshwj xeeb hauv cov uas tsis yog - tib neeg tus qauv kab mob primate thiab kev txhais lus hauv vivo tshawb fawb. Lub tuam txhab tau tsim cov ntaub ntawv pov thawj ntawm cov qauv NHP uas nthuav dav cov kab mob plawv, hematological, thiab hauv nruab nrab paj hlwb indications, suav nrog:
Kev txhawb nqa los ntawm kev muaj peev xwm ua haujlwm siab tshaj plaws, ntau qhov chaw kho mob cov duab thaij duab, thiab cov kev paub dhau los hauv vivo pharmacology cov kev tshawb fawb, Prisys muab kev tshawb fawb txog kev tshawb fawb txog kev kho tshiab, suav nrog biologics, tshuaj kho noob, thiab cell- kho raws li kev kho mob.
Cov kev pabcuam suav nrog kev txhim kho tus qauv kab mob, kev tshawb fawb pharmacokinetic/pharmacodynamic (PK/PD), kev ntsuas kev ua tau zoo, kev ntsuam xyuas biomarker, thiab kev tshawb fawb kev txhais lus tsim los tsim cov ntaub ntawv kho mob rau cov kev txhim kho tshuaj.
Saib tom ntej
Raws li kev kho mob plawv txuas ntxiv hloov mus rau cov tshuaj kho dua tshiab thiab cov noob-raws li kev cuam tshuam, qhov kev thov rau cov qauv kev kho mob uas muaj feem cuam tshuam txuas ntxiv mus ntxiv.
Kev koom tes ntawm NHP lub plawv tsis ua hauj lwm cov ntaub so ntswg rau qhov kev tshawb fawb telomere restoration gene therapy underscores qhov tseem ceeb ntawm qib siab loj- tsiaj cov qauv hauv kev siv cov kab mob thiab ua kom muaj kev kho tshiab.
Leveraging nws cov kev txawj ntse nyob rau hauv tsis yog - tib neeg primate kab mob qauv, nyob rau hauv vivo pharmacology, thiab translational kev tshawb fawb, Prisys Biotechnologies tseem cog lus los txhawb txoj kev loj hlob ntawm tom ntej no - tiam kev kho mob plawv thiab pab txuas qhov sib txawv ntawm kev kuaj nrhiav pom thiab kev siv tshuaj kho mob.
Zhao Y, Bao X, Xiong W, et al.Hloov kho hTERT kho kom txo qis siab tshaj - ua rau lub plawv tsis ua haujlwm. EBioMedicine. 2026; 126. DOI: 10.1016/j.ebiom.2026.106203.
FAQ
Q: Prisys Biotechnologies ua lub luag haujlwm li cas hauv eBioMedicine txoj kev kho noob caj noob ces?
A: Prisys Biotechnologies muab siab -zoo cynomolgus liab lub plawv tsis ua hauj lwm cov ntaub so ntswg cov qauv uas txhawb kev siv tau ntawm cov txheej txheem pathological tseem ceeb, ua kom pom kev sib txuas ntawm telomere tsis ua haujlwm thiab lub plawv tsis ua haujlwm nyob rau hauv ib qho kev txhais lus loj - qauv tsiaj.
Q: Vim li cas ho tsis yog -tib neeg primate (NHP) cov qauv nyiam dua cov nas hauv kev tshawb fawb plawv?
A: NHPs muaj cov kab mob plawv, cov kab mob hauv cov hlab ntsha, cov yam ntxwv ntawm electrophysiological, thiab lub cev tiv thaiv kab mob uas zoo ib yam li tib neeg, ua rau lawv muaj txiaj ntsig zoo rau kev txhais lus txuas ntxiv rau cov kev kho mob siab heev xws li cov noob caj noob ces thiab kev kho ntawm tes.
Q: Dab tsi ntawm NHP kab mob plawv thiab kab mob hematological qauv Prisys muab?
A: Prisys muab cov ntaub ntawv nthuav dav ntawm cov qauv NHP, suav nrog Mob Myocardial Infarction (AMI), Heart Failure (HF), Hemophilia A, Arteriovenous (A{0}}V) Shunt Thrombosis, thiab Mob Ntshav Qab Zib / Shock.
