Yog tias koj yog ib tus kws tshawb fawb ua haujlwm hauv kev kho noob caj noob ces, tej zaum koj yuav paub txog CRISPR / Cas9 thev naus laus zis. Tab sis koj puas tau txiav txim siab siv cov primates uas tsis yog tib neeg los ua tus qauv tsim los ua koj qhov kev tshawb fawb? Hauv cov ntawv tshaj tawm no, peb yuav tshawb xyuas qhov zoo ntawm kev siv cov qauv tsis yog tib neeg primate hauv CRISPR kev tshawb fawb thiab muab cov kev coj ua zoo tshaj plaws rau kev ua kom muaj txiaj ntsig zoo tshaj plaws.
Gene kho yog ib qho cuab yeej muaj zog uas tau hloov pauv ntawm kev tshawb fawb biomedical, thiab CRISPR / Cas9 system yog ib txoj hauv kev zoo tshaj plaws rau kev kho cov noob caj noob ces. Txawm li cas los xij, txhawm rau ua kom kho cov noob tau zoo dua, cov kws tshawb fawb tab tom tig mus rau cov qauv tsis yog tib neeg primate thaum lawv sib koom cov caj ces zoo sib xws thiab lub cev nrog tib neeg.
Qhov zoo ntawmNonhuman Primate ModelsHauv CRISPR Kev Tshawb Fawb:
Nonhuman primates muaj ntau yam zoo dua lwm yam tsiaj qauv thaum nws los txog rau kev tshawb fawb CRISPR. Lawv qhia ntau yam ntawm peb cov caj ces pleev thiab lub cev nqaij daim tawv, ua rau lawv muaj tseeb dua sawv cev ntawm kev kho cov noob yuav ua haujlwm li cas hauv tib neeg. Tsis tas li ntawd, cov primates tsis yog tib neeg muab cov neeg tshawb nrhiav nkag mus rau ntau hom tsiaj, txhua tus muaj cov yam ntxwv tshwj xeeb thiab cov txiaj ntsig uas tuaj yeem siv tau rau cov hom phiaj kev tshawb fawb tshwj xeeb. Nonhuman primates tau siv dav ua qauv tsiaj vim lawv qhov zoo ib yam li tib neeg biology, thiab lawv siv hauv CRISPR kev tshawb fawb tau muab ntau yam zoo, suav nrog:
- Zoo sib xws rau tib neeg nyob rau hauv genetic pleev thiab physiology
- Muaj ntau hom kev tshawb fawb sib txawv
Cov kev coj ua zoo tshaj plaws rau kev ua CRISPR Kev Tshawb Fawb Kev Siv Cov Qauv Uas Tsis Zoo
Txhawm rau kom muaj kev ncaj ncees thiab siv tau zoo ntawm cov qauv tsis yog tib neeg primate hauv CRISPR kev tshawb fawb, kev xaiv cov hom zoo raws li lub hom phiaj kev tshawb fawb yog qhov tseem ceeb. Cov kws tshawb fawb tseem yuav tsum ua raws li kev coj noj coj ua nruj me ntsis txhawm rau tswj hwm lub meej mom thiab kev noj qab haus huv ntawm cov tsiaj uas koom nrog. Cov txuj ci xws li electroporation thiab viral vectors tuaj yeem siv los xa cov khoom CRISPR mus rau hauv cov hlwb uas tsis yog tib neeg.
Kev cuam tshuam yav tom ntej thiab muaj peev xwm tawg tau hauv CRISPR Kev Tshawb Fawb Siv Cov Qauv Uas Tsis Zoo
Nrog rau kev siv txuas ntxiv ntawm cov qauv tsis yog tib neeg primate hauv CRISPR kev tshawb fawb, muaj peev xwm ua tau zoo rau kev ua tiav ntau dua. Nws tuaj yeem ua rau muaj kev kho tshiab thiab kho cov kab mob caj ces xws li cystic fibrosis, Huntington's disease, thiab sickle cell anemia.
Hauv kev xaus, cov qauv tsis yog tib neeg primate ua lub luag haujlwm tseem ceeb hauv kev nce qib ntawm CRISPR noob kho tshuab. Los ntawm kev siv cov qauv no, cov kws tshawb fawb tuaj yeem ua qhov zoo thiab raug kho cov noob caj noob ces uas tuaj yeem ua rau muaj kev tshawb pom. Nrog txuas ntxiv kev nce qib hauv daim teb no, peb yog ib kauj ruam ze dua rau kev qhib lub peev xwm ntawm CRISPR / Cas9 noob kho tshuab.
