Kev tsim tshuaj yog qhov nyuaj heev thiab ntau cov teb ntau. Hauv cov txheej txheem no, kev txheeb xyuas kev sib xyaw ntawmPharmaconininetics (pk)thiabKws Tshuaj (Pd)yog qhov tseem ceeb tshaj plaws tseem ceeb, ua haujlwm ua tus choj tseem ceeb txuas nrog kev tshawb fawb ua ntej thiab chaw kho mob. Tsis pub dhau ntawm kev lag luam kws tshuaj, kev kawm, thiab cov kws tshawb fawb, cov kws tshawb fawb tseem niaj hnub ua rau cov kev tshawb fawb preclinical tsis tu ncua. Muab cov nyom ntawm cov tshuaj metabolism hauv kev siv tshuaj ntsuab, peb tuaj yeem txhais tau qhov tseeb li cas ntawm cov txheej txheem thiab kev siv yeeb tshuaj ntawm cov ntsiab lus sib txawv? Thiab vim li cas PK / PD cov ntaub ntawv feem ntau tsis pub dhau hauv cov tshuaj ntsuam xyuas tsis meej? Cov lus nug no suav cov kev sib txuam ntawm kev sib koom ua ke ntawm cov kws tshuaj hauv kev tshuaj.
Kab lus no ua kom delve rau hauv cov ntsiab lus tseem ceeb thiab kev siv pk / pd kev xav. Peb yuav tsom rau cov ntsiab lus nram qab no:Lub Hom Phiaj Biology, confentration-nyhuv kev sib raug zoo, cov lus txhais-lub sij hawm txhais lus ntawm cov qauv sib txuas lus, thiab qhov tseem ceeb ntawm kev sib txuas lus tseem ceebCov. Los ntawm kev tshawb xyuas kev tshawb fawb nruj heev, lub hom phiaj yog los txhim kho cov ntawv thov ntawm PK / PD kev koom ua ke hauv kev tsim tshuaj.
Cov tshuaj kho mob kab mob feem ntau yuav tsum ua kom cov dosing regimens. Thaum lub sij hawm rov ua dua, kev sib raug zoo ntawm kev tshuaj ntsuam kev raug tshuaj thiab cov chaw muag tshuaj yog maj mam tsim tau, txuas ntxiv mus tshuaj-kev sib raug zoo. Thaum cov kev sib raug zoo ntawm cov tshuaj-teb tau pom rau ob qho tshuaj thiab tshuaj noj), thiab cov tshuaj uas khov kho (lossis raug cov tshuaj tiv thaiv) yog qhov tseem ceeb tshaj plaws ua ib qho tseem ceeb tshaj plaws. Thaum lub sij hawm khov kho-cuam tshuam kev sib raug zoo xws li xaiv cov txheej txheem tseem ceeb, nws tuav cov ntaub ntawv cuav, thiab kev ntsuas cov paj ntaub thiab kev nyab xeeb.
Kev xav-lub sij hawm, lub siab-siab-nyhuv, thiab cov ntaub ntawv siv sijhawmTam sim no cov kev pabcuam tshwj xeeb hauv PK / PD tsom xam. Muaj qee kis,Hauv vivoCov nyhuv-lub sij hawm nkhaus yuav xav tau simulated thiab kwv yees siv cov ntaub ntawv uas twb muaj lawm thiab hauv cov ntaub ntawv vitro (lossis khi cov ntaub ntawv) -concentration. Sib tham, cov ntaub ntawv siab thiabHauv vivoCov ntaub ntawv siv sij hawm yuav tuaj yeem ua tau ncaj qha rau kev sim, thiab qhov sib npaug concentration ntawm lub nyob rau hauv Vivo nyhuv kuj tseem tuaj yeem txiav txim siab. Tsis tas li ntawd, raws liHauv vitroCov ntaub ntawv cuam tshuam zoo-cov ntaub ntawv, nws yog qhov ua tau los twv cov ntaub ntawv Vivo Cov ntaub ntawv sib txawv thiab lawv cov txheej txheem txheeb xyuas muab kev pom zoo rau kev nkag siab tob txog kev ua yeeb tshuaj.
Cov Ntsiab Lus Tseem Ceeb ntawm PK / PD kev xav tau muaj pes tsawg yam hauv qab no:
Phiaj Banology:Ib qho kev nkag siab zoo ntawm lub hom phiaj biology biology yog qhov tseem ceeb rau PK / PD qauv thiab kev txhais. Qhov no suav nrog lub hom phiaj kev ua haujlwm ntawm lub cev, teeb tsa txoj hauv kev, kev mob kis, thiab cov txheej txheem molecular ntawm kev sib cuam tshuam nrog cov tshuaj.
Kev Tsim Kho-Nyuaj Siab: Qhov ntau ntawm cov kev sib txheeb ntawm kev sib raug zoo thiab cov tshuaj uas muag tshuaj, feem ntau yog tsim los ntawm cov kev sim vitro lossis hauv Vivo kev sim. Feem ntau siv cov qauv suav nrog EMAX qauv, sigmoid Emax qauv, thiab lwm yam, los piav qhia txog kev sib raug zoo ntawm kev siv tshuaj thiab cov nyhuv.
Cov nyhuv-lub sij hawm nkhaus:Dynamically saib cov qauv ntawm cov tshuaj tau hloov pauv thaum lub sijhawm tom qab cov tshuaj tswj. Ua ke nrog pk cov ntaub ntawv, nws tso cai rau kev soj ntsuam latency, ntev, thiab kev sib txheeb nrog cov tshuaj hauv cov tshuaj hauv cov tshuaj.
Neeg txhais lus & Scaling ntawm Cov Qauv Qauv: Tsim li extrapolating extrapolating preclinerical pk / pd qauv tsis ua rau tib neeg yog ib qib tseem ceeb hauv PK / PD kev koom ua ke. Qhov no cuam tshuam rau hom kev sib txawv, cov kev tswj hwm ntawm kev tswj hwm, kev ua siab physiological, thiab lwm yam, txhawm rau txhim kho qhov tseeb ntawm kev soj ntsuam kev tshawb pom.
Interdisciplinary sib txuas lus: Tshuaj Kev Txhim Kho muaj ntau txoj kev qhuab qhia suav nrog cov chaw muag tshuaj, tshuaj chemical, thiab tshuaj kho tshuaj. Kev sib txuas lus zoo tshaj yog qhov tseem ceeb lees paub txog kev ua tiav cov tswv yim PK / PDOring kev ua haujlwm ntawm cov phiaj xwm du.
Kev sib txuas lus biology, kev thov tsis raug cai ntawm kev sib txuas lus hauv cov tshuaj, thiab txawm tias ua rau tsis muaj kev cog lus cov tshuaj tiv thaiv cov tshuaj tiv thaiv cov tshuaj. Piv txwv li, kev tsis nkag siab ntawm lub hom phiaj ntawm kev ua tau tuaj yeem ua rau kev txiav txim siab tsim kho thiab cuam tshuam cov kev taw qhia ntawm txhuas kev ua kom zoo. Cov lus txhais tsis tau ntawm cov qauv tsis sib xws, suav nrog kev ua phem rau cov kev nyab xeeb rau kev nyab xeeb rau kev nyab xeeb rau kev nyab xeeb, tuaj yeem tsim nyog, lossis xaiv cov kev tiv thaiv.
Yog li ntawd, nyob rau hauv cov txheej txheem txhim kho kev tsim kho, kev sib koom tes zoo thiab kev sib raug zoo, yog qhov tseem ceeb ntawm cov haujlwm sib txawv, muaj kev nyab xeeb sai sai, muaj kev nyab xeeb sai sai, muaj kev nyab xeeb sai sai, muaj kev nyab xeeb sai sai, muaj kev nyab xeeb sai sai, muaj kev nyab xeeb thiab kev ua kom zoo dua qub lossis kev kho mob thaum ntxov. Los ntawm kev thov kev sib xyaw ua ke ntawm PK / PD cov tswv yim sib xyaw ua ke, peb tuaj yeem cia siab rau kev tshawb fawb thiab kev txhim kho cov tshuaj tshiab thiab ua rau tib neeg kev noj qab haus huv.
