Hauv Vivo Immune Cell Tracking & PET Tracer Development hauv NHP Qauv|Prisys Biotech

Hauv kev txhim kho cov kev kho mob siab heev xws li CAR-T cells, dendritic cell (DC) cov tshuaj tiv thaiv, thiab cov tshuaj radiopharmaceuticals, nkag siab txog kev faib tawm spatiotemporal, lub hom phiaj kev koom tes, thiab kev pheej hmoo ntawm cov tshuaj tua kab mob hauv vivo yog ib qho tseem ceeb ntawm kev ntsuam xyuas preclinical. Cov txheej txheem ib txwm siv-xws li histopathology thiab ex vivo fluorescence tsom xam- yog qhov muaj feem cuam tshuam los ntawm lawv qhov xwm txheej thiab tsis muaj peev xwm muab cov ntaub ntawv txuas ntxiv, tag nrho - lub cev muaj zog.

Txhawm rau hais txog cov kev txwv no, cov qauv tsis yog-tib neeg primate (NHP) ua ke nrog kev kuaj mob- qib PET/CT imaging tau tshwm sim los ua ib qho kev txhais tau zoo heev rau qhov ntev, qhov ntau, thiab tsis yog- tawm tsam ntawm lub cev tiv thaiv kab mob thiab molecular probes. Txoj hauv kev no tso cai rau lub sijhawm tiag tiag - pom cov txheej txheem lom neeg nyob rau hauv cov xwm txheej ntawm lub cev zoo li tib neeg lub cev.

NtawmPrisys Biotech, lub peev xwm no tau muab tso ua ke rau hauv cov kev txhais lus dav dav, txhawb nqa ob qho tib si kev tshuaj xyuas ntawm tes thiab kev txhim kho PET tshiab nyob rau hauv cov txheej txheem kho mob.

Ib qho kev sib tw hauv nruab nrab hauv kev txhim kho ntawm tes yog qhov muaj peev xwm ua kom pom tseeb hauv vivo kinetics ntawm cov hlwb infused, suav nrog lawv cov biodistribution, tsiv teb tsaws, nthuav dav, thiab cov ntaub so ntswg- tshwj xeeb hauv tsev.

Prisys Biotech ntiav radiolabel-raws li xov tooj ntawm tes nrhiav cov tswv yim ua ke nrog siab - daws teeb meem PET/CT imaging los daws qhov kev xav tau no. Cov kab mob tiv thaiv kab mob xws li T hlwb lossis cov hlwb dendritic tuaj yeem sau npe ex vivo siv positron-emitting isotopes, ua kom muaj kev cuam tshuam thiab nrhiav kom muaj nuj nqis tom qab rov- infusion rau hauv NHP qauv.

Ib qho ntawm feem ntau siv isotopes hauv cov ntsiab lus no yog Zirconium-89 (⁸⁹Zr). Nrog rau ib nrab ntawm lub cev - lub neej ntawm kwv yees li 3.27 hnub, ⁸⁹Zr yog qhov tshwj xeeb zoo - haum rau nruab nrab - mus txog qhov ntev - cov kev tshawb fawb txog kev tshawb nrhiav, tso cai rov ua duab ntau dua ob peb hnub yam tsis muaj teeb meem loj. Tom qab kev tswj hwm, tag nrho lub cev PET / CT scans tuaj yeem ua tiav ntawm lub sijhawm teev tseg los ua kom muaj nuj nqis biodistribution maps.

Txoj hauv kev no muab ntau qhov txiaj ntsig tseem ceeb:

• Ua haujlwm tsis yog-terminal, longitudinal kev soj ntsuam ntawm txoj hmoo ntawm tes
• Txhawb kom muaj nuj nqis tsom xam ntawm cov ntaub so ntswg- tshwj xeeb tsub zuj zuj (piv txwv li, lymph nodes, spleen, pob txha pob txha, qog los yog inflammatory sites)
• Ua kom yooj yim rau kev ntsuam xyuas ntawm lub hom phiaj kev ua tau zoo, kev nyab xeeb ntawm lub cev, thiab lub sijhawm khaws cia
• Txo kev sib tshuam -tsiaj hloov pauv los ntawm kev tso cai rov ntsuas dua hauv tib yam kev kawm

Qhov tseem ceeb, kev siv cov qauv NHP ua kom ntseeg tau tias cov ntaub ntawv no cuam tshuam txog kev coj tus cwj pwm ntawm lub cev tiv thaiv kab mob, ua kom muaj txiaj ntsig zoo rau kev tshawb fawb tib neeg.

Tshaj li kev taug qab kho cov hlwb, tib lub phiaj xwm duab txhawb kev tsim kho tshiab PET tracers rau kev kuaj mob thiab kev siv theranostic.

Nyob rau hauv thaum ntxov-txoj kev txhim kho kab mob, nws yog ib qho tseem ceeb rau kev ntsuam xyuas:

• Lub hom phiaj tshwj xeeb thiab khi affinity
• Nyob rau hauv vivo stability thiab metabolic profile
• Tag nrho - lub cev faib thiab tshem tawm txoj hauv kev
• Radiation dosimetry thiab kev nyab xeeb

Cov qauv nas feem ntau tsis tuaj yeem ntes qhov nyuaj ntawm tib neeg lub cev lub cev, tshwj xeeb tshaj yog rau cov neeg taug qab lub hom phiaj tiv thaiv kab mob, paj hlwb, lossis kab mob metabolic. Hauv qhov sib piv, NHP cov qauv muab siab anatomical thiab physiological zoo sib xws rau tib neeg, ua rau lawv tus choj tseem ceeb ntawm kev tshawb fawb tsiaj me thiab kev sim tshuaj.

Prisys Biotech tso cai rau qhov kawg -rau- qhov kawg tracer ntsuam xyuas, suav nrog:

• Radiolabeling tswv yim txhim kho thiab optimization
• PET / CT imaging raws tu qauv tsim raws li cov qauv kev kho mob
• Quantitative duab tsom xam thiab kinetic qauv
• Kev sib raug zoo nrog bio-cov ntaub ntawv piv txwv (Pharmacokinetics (PK), Pharmacodynamics (PD), biomarker tsom xam)

Lub zog ntawm txoj hauv kev no tsis yog nyob rau hauv kev yees duab yees nkaus xwb, tab sis nyob rau hauv kev koom ua ke ntawm ntau yam kev tshawb fawb kev txhais lus hauv ib lub platform.

Prisys Biotech ua haujlwm kho mob- sib npaug ntawm cov duab kos duab, suav nrog PET/CT, MRI, CT, thiab DSA systems, txhawb nqa los ntawm cov kws paub txog hluav taws xob thiab ntau pawg kws tshawb fawb. Cov peev txheej no pab tau:

• Hla- qauv duab rau kev ntsuam xyuas cov kab mob thiab cov lus teb kho mob
• Duab -kev taw qhia, suav nrog kev xa mus rau lub hom phiaj thiab kev kuaj ntshav
• Quantitative endpoint txhais tau raws li kev soj ntsuam kev sim txheej txheem

Tsis tas li ntawd, lub platform yog embedded nyob rau hauv ib tug dav NHP translational kev tshawb fawb ecosystem, uas muaj xws li:

• Ib tug ntau yam portfolio ntawm kab mob qauv thoob plawsCNS/Neurology, Immunology & Inflamation, respirology, thiab cardiometabolism indications
• PK / PD thiab bioanalytical muaj peev xwm rau kev soj ntsuam kws tshuaj sib xyaw
• Advanced technologies xws liMRI-Kev Qhia Qhia Tshuaj Rau CNS Kev Tshawb FawbthiabAI-raws li NHP Behavior Analysis System
• Tsiaj-Nyob zoo(AAALAC- tau lees paub) cov chaw ua kom ntseeg tau cov qauv siab ntawm kev noj qab haus huv tsiaj thiab kev ua raws cai

Hauv vivo kev tiv thaiv kab mob hauv lub cev thiab kev txhim kho PET tracer sawv cev rau cov khoom tseem ceeb ntawm kev txhim kho cov tshuaj niaj hnub no, tshwj xeeb tshaj yog nyob rau hauv kev tiv thaiv kab mob, oncology, thiab cov tshuaj precision.

Los ntawm kev sib koom ua ke tsis yog - tib neeg primate qauv nrogClinical Imagingtechnologies, cov kws tshawb fawb tuaj yeem ua tiav:

• Direct visualization ntawm cellular thiab molecular dynamics nyob rau hauv lub systems
• Ntau, cov ntaub ntawv ntev uas txhawb kev txiav txim siab- ua
• Txhim khu kev txhais lus muaj feem xyuam rau kev kho mob

Prisys Biotech muab lub platform sib xyaw ua ke uas txuas qhov sib txawv ntawm kev tshawb fawb ua ntej thiab daim ntawv thov kev kho mob, ua kom paub ntau ntxiv txog kev ntsuam xyuas ntawm cov tswv yim kho mob thiab ua kom muaj kev txhim kho ntawm - tiam tom ntej kev kuaj mob thiab kev kho mob.

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