Taw qhia rau Immunotoxicity
Immunotoxicity hais txog qhov tsis zoo ntawm cov tshuaj exogenous ntawm lub cev tiv thaiv kab mob. Kev ntsuas qhov muaj peev xwm ntawm tus neeg siv tshuaj tiv thaiv kab mob hauv lub cev yog ib qho tseem ceeb ntawm kev txhim kho cov tshuaj uas tsis muaj tshuaj kho mob, tshwj xeeb tshaj yog thaum cov kev tshawb fawb tshuaj toxicity qhia tau hais tias muaj kev hloov pauv hauv lub cev tiv thaiv kab mob - cov tsis muaj feem cuam tshuam.
Cov teebmeem Immunotoxic tuaj yeem ua ntau hom.Kev tiv thaiv kab mobTej zaum yuav ua rau lub cev tsis muaj zog thiab ua rau muaj kev cuam tshuam rau kev kis kab mob lossis muaj feem cuam tshuam rau kev soj ntsuam qog. Piv txwv li, kev tiv thaiv kab mob ntau dhau lossis tsis tsim nyog yuav ua rau muaj kev ntxhov siab, cov lus teb autoimmune, lossis lwm yam kev tiv thaiv tsis zoo.
Thaum cov kev tshawb pom los ntawm cov kev tshawb fawb toxicity pom tau hais tias muaj peev xwm cuam tshuam rau lub cev tiv thaiv kab mob, kev tshawb fawb ntxiv ntawm immunotoxicity tuaj yeem raug xaiv raws li qhov tshwm sim ntawm cov kev hloov pauv, cov tshuaj pharmacological ntawm cov khoom sib xyaw, thiab kev npaj siv cov ntaub ntawv. Vim tias lub cev tiv thaiv kab mob tuaj yeem nkag siab rau cov tshuaj exogenous, qhov kev ntsuam xyuas lub hom phiaj yuav raug lees paub rau cov tebchaw uas muaj peev xwm cuam tshuam rau kev tiv thaiv kab mob.
Immunotoxicity Studies ntawm Prisys
Prisys Biotechnologies txhawb nqa kev tshawb fawb txog kev tiv thaiv kab mob hauv lub cev siv ntau yam hauv vitro thiab hauv vivo txoj hauv kev. Nyob ntawm lub hom phiaj ntawm txoj kev kawm, hom, cov yam ntxwv sib xyaw, thiab cov kev tshawb pom pom, cov tswv yim kev soj ntsuam tuaj yeem suav nrog cov kev ntsuas tshuaj lom neeg thiab cov ntsiab lus ntxiv rau kev ua haujlwm lossis kev tiv thaiv kab mob.
1. Kev Tshawb Fawb Txog Kev Ua Phem Txhaum Cai
Kev ntsuam xyuas toxicity tej zaum yuav muaj xws li:
- Hematology thiab kev kho mob chemistry
- Tag nrho cov pathology thiab kev ntsuas lub cev hnyav
- Kev kuaj mob histopathological
- Kev ntsuas kev ntxhov siab- cuam tshuam txog kev hloov pauv
- Cov koob tshuaj siab tshaj plaws (MTD) thiab koob tshuaj -kev tshawb fawb
- Ib zaug - kev tshawb fawb tshuaj toxicity
- Rov ua dua -kev tshawb fawb txog tshuaj toxicity
- Kev tshawb fawb hypersensitivity
- Kev ntsuam xyuas hemolysis
- Kev tshawb nrhiav kev khaus hauv zos
- Hauv kev tshawb fawb vivo phototoxicity
Cov kev ntsuam xyuas no tuaj yeem muab cov ntaub ntawv thawj zaug ntawm cov kab mob toxicity thiab muaj peev xwm hloov pauv cuam tshuam rau lub cev tiv thaiv kab mob.
2. Kev tshawb fawb txog Immunotoxicity ntxiv
Yog tias muaj kev tiv thaiv tiv thaiv kab mob ntxiv, kev tshawb fawb ntxiv yuav suav nrog:
- Test characterization thiab assay qualification lossis verification
- T-cell-nyob ntawm cov tshuaj tiv thaiv kab mob(TDAR)
- ncua -hom hypersensitivity(DTH)
- Immunophenotyping
- Natural killer (NK) kev ua haujlwm ntawm tes
- Cov kev tshawb fawb tiv thaiv tus tswv
- Macrophage thiab neutrophil muaj nuj nqi
- Cellular kev tiv thaiv kev ua haujlwm
Kev xaiv ntawm cov ntsiab lus kawg yuav tsum tau ua raws li qhov xav tau ntawm cov txheej txheem thiab cov kev tshawb pom tshwj xeeb ntawm kev tiv thaiv kab mob hauv lub sijhawm kawm.
3. Juvenile Animal Studies
Rau cov kev pab cuam uas xav tau kev ntsuam xyuas hauv cov tsiaj me, cov ntsiab lus kawg yuav suav nrog:
- Kev loj hlob ntawm lub cev thiab kev sib deev
- Reflex thiab kev txhim kho kev ua haujlwm
- Kev ua ub ua no
- Kev kawm thiab kev nco
- Kev loj hlob hormone thiab insulin-zoo li kev ntsuas kev loj hlob
- Kev soj ntsuam phev
- Pob txha ceev thiab kev ntsuam xyuas pob txha loj
4. Kev tshawb fawb txog kev nqus pa
Rau cov neeg siv tshuaj nqus tau pa, immunotoxicity thiab lub zos tolerability tuaj yeem raug soj ntsuam ua ke nrog kev ntsuas ua pa. Tej zaum cov ntsiab lus kawg suav nrog
