Lub hlwb yog qhov nyuaj tshaj plaws thiab tseem ceeb tshaj plaws hauv tib neeg lub cev, lub luag haujlwm los tswj peb txoj kev xav, kev xav, kev nco, thiab kev coj cwj pwm. Txawm li cas los xij, lub paj hlwb tseem muaj kev cuam tshuam rau ntau yam kab mob thiab kab mob, xws li Alzheimer's, Parkinson's, qog hlwb, mob stroke, thiab lwm yam. Cov xwm txheej no tuaj yeem ua rau lub hlwb ua haujlwm tsis zoo thiab cuam tshuam rau kev ua neej zoo ntawm ntau lab tus tib neeg.
Ib qho ntawm cov teeb meem loj hauv kev tsim cov kev kho mob zoo rau cov kab mob hauv lub hlwb yog cov ntshav -b hlwb barrier (BBB), txheej tiv thaiv ntawm cov hlwb uas nyob ib puag ncig lub hlwb thiab tiv thaiv cov khoom tsis zoo nkag mus. BBB yog qhov tseem ceeb rau kev tswj xyuas lub hlwb homeostasis thiab tiv thaiv kev kis kab mob, tab sis nws tseem thaiv cov tshuaj feem ntau los ntawm lub hlwb, tshwj xeeb tshaj yog cov molecules loj xws li biologics.
Biologics yog ib chav kawm ntawm cov tshuaj uas tau muab los ntawm cov kab mob muaj sia, xws li tshuaj tiv thaiv kab mob, enzymes, cov tshuaj hormones, thiab kev loj hlob. Lawv muaj ntau yam zoo dua li cov tshuaj me me me me, xws li kev ua haujlwm siab, muaj zog, thiab kev nyab xeeb. Txawm li cas los xij, biologics kuj loj, hydrophilic, thiab tsis ruaj khov, uas ua rau lawv nyuaj rau hla BBB los ntawm passive diffusion lossis kev thauj mus los.
Hmoov zoo, cov kws tshawb fawb tau pom qee txoj hauv kev los kov yeej BBB thiab xa cov biologics rau lub hlwb, los ntawm kev siv cov txheej txheem ntuj uas lub hlwb siv los thauj cov khoom noj thiab cov cim. Cov txheej txheem no koom nrog cov receptors uas tau nthuav tawm ntawm qhov chaw ntawm BBB endothelial hlwb, uas tuaj yeem kho cov endocytosis thiab transcytosis ntawm lawv cov ligands. Los ntawm kev txuas cov kab mob biologics rau cov ligands, lossis tsim cov tshuaj tiv thaiv kab mob lossis peptides uas tuaj yeem khi rau cov receptors no, biologics tuaj yeem thauj mus thoob BBB thiab ncav cuag lub hlwb.
Qee qhov receptors uas tau kawm txog kev xa khoom biologics yog:
Transferrin receptor (TfR: TfR yog ib qho receptor uas khi rau transferrin, cov protein uas nqa cov hlau hauv cov ntshav. TfR tau qhia ntau heev ntawm BBB endothelial hlwb thiab tuaj yeem ua rau sab hauv thiab transcytose transferrin. Biologics tuaj yeem sib txuas rau transferrin lossis anti-TfR antibodies nkag mus rau hauv lub hlwb ntawm txoj kev no, raws li txoj hauv kev. JR-141, tau txais kev pom zoo rau kev kho mob mucopolysaccharidosis hom II, tsis tshua muaj caj ces kab mob uas cuam tshuam rau lub hlwb thiab lwm yam kabmob.
Insulin receptor (IR) IR yog ib qho receptor uas khi rau insulin, ib yam tshuaj uas tswj cov ntshav qabzib. IR kuj tau nthuav tawm ntawm BBB endothelial hlwb thiab tuaj yeem ua rau sab hauv thiab transcytose insulin. Biologics tuaj yeem txuas rau insulin lossis tiv thaiv -IR cov tshuaj tiv thaiv kom nkag mus rau lub hlwb ntawm txoj hauv kev no. Piv txwv li, cov kws tshawb fawb tau siv cov tshuaj tiv thaiv -IR cov tshuaj tiv thaiv kom xa cov paj hlwb- tau txais txiaj ntsig neurotrophic (BDNF), cov protein uas txhawb nqa kev muaj sia nyob thiab kev ua haujlwm, rau lub hlwb ntawm cov liab.
Low density lipoprotein receptor (LDLR): LDLR yog ib qho receptor uas khi rau cov lipoproteins tsawg (LDL), ib hom lipoprotein uas nqa cov roj cholesterol hauv cov ntshav. LDLR tau dav dav hauv daim siab, phab ntsa hlab ntsha, adrenal cortex, thiab lwm yam ntaub so ntswg, nrog rau BBB endothelial hlwb. LDLR tuaj yeem tsim thiab hloov pauv LDL thiab lwm yam lipoproteins uas muaj ApoB100 lossis ApoE, xws li VLDL thiab -VLDL. Biologics tuaj yeem muab tso rau hauv liposomes lossis nanoparticles uas muaj cov apolipoproteins, lossis sib txuas rau peptides uas tuaj yeem khi rau LDLR, nkag mus rau lub hlwb ntawm txoj kev no. Piv txwv li, cov kws tshawb fawb tau siv LDLR-binding peptides kom xa paclitaxel nanoparticles, tshuaj kho mob, mus rau lub hlwb ntawm cov nas uas muaj glioblastoma, hom mob hlwb hauv hlwb.
Cov no tsuas yog qee qhov piv txwv ntawm cov receptors uas tuaj yeem siv rau kev xa mus rau lub hlwb. Muaj ntau lwm cov receptors uas tau tshawb nrhiav lossis tab tom tshawb nrhiav, xws li leptin receptor, receptors ntawm cov khoom siab tshaj glycation endproducts, scavenger receptor, thiab low density lipoprotein receptor-related protein 1. Txhua tus ntawm cov receptors muaj nws qhov zoo thiab qhov tsis zoo, xws li qhov tshwj xeeb, affinity, kev nthuav qhia theem, thiab kev nyab xeeb. Yog li, qhov kev xaiv zoo tshaj plaws ntawm receptor nyob ntawm seb hom, qhov loj me, thiab lub hom phiaj ntawm cov kab mob biologic, nrog rau cov kab mob thiab cov yam ntxwv ntawm tus neeg mob.
Biologics xa mus rau lub hlwb yog qhov kev cog lus thiab nyuaj ntawm kev tshawb fawb, uas tuaj yeem qhib tau tshiab rau kev kho mob hlwb. Txawm li cas los xij, tseem muaj ntau yam teeb meem thiab tsis paub tseeb yuav kov yeej, xws li kev tsim kho kom zoo, kev tsim, thiab kev tswj hwm ntawm biologics, cov kev mob tshwm sim thiab toxicity ntawm biologics thiab receptor-kev thauj mus los, kev coj ncaj ncees thiab kev tswj hwm, thiab tus nqi thiab kev ua tau zoo ntawm biologics ntau lawm thiab xa khoom.
Ntawm Prisys Biotechnology, peb tau cog lus los tsim kho tshiab thiab siv tau zoo biologics rau kev kho mob hlwb, siv kev txiav- thev naus laus zis thiab cov txheej txheem tshawb fawb nruj. Peb muaj pab pawg kws tshaj lij hauv biotechnology, pharmacology, toxicology, neuroscience, thiab kev tshawb fawb soj ntsuam, uas ua haujlwm ua ke kom kov yeej cov teeb meem ntawm kev xa khoom biologics mus rau lub hlwb. Peb kuj tseem koom tes nrog cov tsev kawm ntawv, cov koom tes hauv kev lag luam, thiab cov koom haum tswj hwm, kom ntseeg tau qhov zoo, kev nyab xeeb, thiab kev ua tau zoo ntawm peb cov biologics. Peb lub zeem muag yog txhawm rau txhim kho lub neej ntawm ntau lab tus tib neeg uas raug kev txom nyem los ntawm cov kab mob hauv lub hlwb, los ntawm kev muab lawv cov kev kho mob tshiab thiab kho tus kheej.
