Prisys Biotechspecializes nyob rau hauv advanced nonhuman primate (NHP) kev tshawb fawb, leveragingcynomolgus liab qauvthiab translational platforms los txhawb kev txhim kho tshuaj preclinical. NrogAAALAC kev lees paub tag nrho, peb txhawb nqa cov qauv siab tshaj plaws ntawm kev noj qab haus huv tsiaj thiab kev tshawb fawb nruj, ua kom cov tuam txhab biopharmaceutical thoob ntiaj teb tsim cov ntaub ntawv ntseeg tau, kho cov ntaub ntawv kho mob.
Vim li cas Biodistribution Studies tseem ceeb
Kev tshawb fawb biodistribution yog lub hauv paus ntawm kev tshawb fawb preclinical. Lawv muab kev nkag siab tseem ceeb rau hauvabsorption, tis, metabolism, thiab excretion (ADME)profile ntawm cov neeg sib tw tshuaj yeeb tshuaj-tshwj xeeb yog lawv qhov chaw nyob thiab kinetics hauv lub hom phiaj ntawm lub cev thiab cov ntaub so ntswg.
Cynomolgus liab, vim lawvkaw cov noob caj noob ces, physiological, thiab pathological zoo sib xws rau tib neeg, ua tus qauv uas tsis muaj qhov sib piv rau kev kwv yees tib neeg tus cwj pwm yeeb tshuaj. Cov kev tshawb fawb no yog qhov tseem ceeb rau:
- Txo cov kev sim tshuaj tsis ua haujlwm
- Nkag siab txog cov txheej txheem ntawm kev ua
- Optimizing dosing regimens
- Kev ntsuas kev nyab xeeb thiab kev txhawb nqaIND cov ntaub ntawv
Prisys Biotech's Core Platforms for Biodistribution Studies
1. Advanced Imaging & Analysis
- MRI & CT: Nruab nrog1.5T siab -MRIthiab40-sib CT, peb muab siab -kev daws teeb meem nrog kev tshaj tawm qib siab- ua tiav (3D-ASL, perfusion tsom xam, rog kom muaj nuj nqis, pulmonary nodule tsom, cerebral perfusion, thiab lwm yam).
- PET-CT / PET-MR / SPECT: Los ntawm kev koom tes nrog cov tsev kho mob, Prisys muaj cov kev tshawb fawb radiolabeled rauKev ntsuas qhov ntsuas ntawm biodistribution thiab cov metabolism. Piv txwv li, cov kev tshawb fawb tau npaj muaj xws li [18F]-labeled insulin PET-CT rau qhov ntswg- rau- lub paj hlwb.
2. Kev xa tshuaj Precision mus rau lub hom phiaj lub cev
- iMRI-Kev Qhia Qhia Tshuaj: Asia thawj zaug intraoperative MRI -coj kev taw qhia enablessub- millimeter raugrau lub hlwb- lub hom phiaj xa khoom, ua ke nrogconvection-kev xa khoom zoo (CED). Lub platform no tau siv rau hauvgene therapy programs(xws li AMT-130 rau Huntington tus kab mob).
- DSA-Kev taw qhia lub cev Perfusion: Digital subtraction angiography xyuas kom meej vascular phiaj rau cerebral thiab cardiovascular tshuaj xa.
- Nasal-rau-Npaj (N2B) Xa: Optimized devices and imaging assessments support CNS drug delivery strategies.
- Intrathecal (IT) Administration: Ua kom muaj kev ntsuam xyuas ntawm cov teebmeem CNS ncaj qha, suav nrog EEG-raws li kev ntsuas.
3. Kev Ua Haujlwm Bio-Sample Collection & Assays
- Qauv: Ntshav, ntshav, CSF, daim siab biopsies, raum cov ntaub so ntswg, retina, zis, quav, thiab mucosal kuaj.
- Hauv - kev ntsuam xyuas hauv tsev: Hematology, biochemistry, coagulation, flow cytometry, cytokine profileing, IHC, HE staining, RT-qPCR.
- Kev sib koom tes: LC-MS, ELISpot, thiab cov kev pabcuam bioanalytical siab heev nrog cov chaw kuaj mob.
Piv txwv daim ntawv thov
- Neurological ntshawv siab & noob caj noob ces: iMRI- coj kev txhaj tshuaj intracerebral rau oligo, ua kom zootiag -time biodistribution mapping.
- Nasal-rau- lub paj hlwb xa: Kev soj ntsuam cov cuab yeej tshiab rau kev thauj cov tshuaj CNS tau zoo, raug lees paub los ntawm CT imaging thiab fMRI.
- PK & biodistribution kev tshawb fawb: Txheeb xyuas daim siab biodistribution thiab ntshav plasma PK siv biopsies thiab serial sampling.
- Kab mob raum & hloov pauv: Siv MRA thiab histopathology los ntsuam xyuas graft perfusion thiab tshuaj cuam tshuam rau kev tsis lees paub thiab fibrosis.
Vim li cas koom tes nrog Prisys Biotech
- NHP Research Center: 4,000 m² chaw nyob muaj txog li 500 cynomolgus liab nrog rau kev phais tag nrho, duab, thiab ICU muaj peev xwm.
- Pab neeg ua haujlwm ntau yam txuj ci: Cov kws kho mob, kws tshuaj, kws kho tsiaj, thiab cov kws tshawb fawb txhais lus nrog cov kws tshaj lij pov thawj hauv kev tshawb fawb tsiaj loj -.
- Yooj yim sib koom ua qauv: Los ntawm kev tsim qauv tsim kom tiav - mus rau - xaus cov pob khoom preclinical bridging theem preclinical thiab chaw kho mob.
Xaus
Los ntawm kev sib koom ua ke cov duab zoo tshaj plaws, kev xa tshuaj muaj tseeb, thiab cov cuab yeej tshuaj ntsuam xyuas muaj zog,Prisys Biotechmuab siab -zoo, translational biodistribution data. Peb cov qauv cynomolgus liab pab txhawb lub tuam txhab tshuaj thoob ntiaj teb kom ceev cov tshuaj txhim kho, txhim kho kev kho mob, thiab txo cov kev pheej hmoo ntawm kev txhais lus.
📩 Hu rau peb ntawmbd@prisysbiotech.comlos tshawb nrhiav kev sib koom tes.
