Psoriasis yog ib hom kab mob tiv thaiv kab mob ntau yam - cov kab mob sib kis tau tshwm sim los ntawm cov kab mob hauv lub cev thiab lub cev tsis muaj zog. Nws tshwm sim raws li khaus, scaly plaques uas cuam tshuam rau lub neej zoo thiab kev puas siab puas ntsws zoo - ua tus neeg mob. Cov kab mob no feem ntau tshwm sim ntawm lub hauv caug, lub luj tshib, pob tw, thiab tawv taub hau. Cov kev kho mob tam sim no tsom kom qeeb cov tawv nqaij ntau dhau ntawm cov cell loj hlob thiab txo cov tsos mob. Cov no suav nrog kev kho mob tshuaj pleev ib ce, kho duab kho mob, thiab kev kho mob xws li tshuaj tiv thaiv kab mob thiab biologics. Cov lus qhia tsis ntev los no los ntawm American Academy of Dermatology thiab National Psoriasis Foundation (AAD/NPF) pom zoo kom biologics ua thawj - kab kev kho mob rau nruab nrab- rau -plaque psoriasis, muab lawv qhov tshwj xeeb, ua tau zoo, thiab kev nyab xeeb (JAMA, 2020; 323(519): 1964). Yog li ntawd, biologics tau dhau los ua qhov tseem ceeb hauv kev txhim kho tshuaj psoriasis.
Raws li ib tug preclinical CRO specializing nyob rau hauvtsis yog-Human Primate (NHP) pharmacologykev tshawb fawb,Prisys Biotechua tau zoo tshaj plaws hauv kev tsim kho kho mob ntsig txog loj - qauv kab mob tsiaj. Peb lub peev xwm sib koom ua ke hauv vivo pharmacology, hauv vitro analytical test, thiab kev ntsuam xyuas kab mob siab heev. Qhov kev qhia dav dav no tau ua rau Prisys Biotech los ua tus thawj cojcynomolgus liab psoriasis qauv, txhawb kev txhim kho ntawm - tiam tom ntej kho mob psoriasis.
Kev loj hlob ntawm cov Cynomolgus Monkey Psoriasis Model
Prisys Biotech ntiav cov kev paub dav dav imiquimod (IMQ)-induced txoj kev los tsim tus qauv psoriasis. Los ntawm kev tswj hwm tus lej ntawm IMQ rau kev noj qab haus huv cynomolgus liab, peb ua raws li cov kev hloov pauv pathological pom hauv tib neeg psoriasis. Hauv peb cov kev tshawb fawb, peb tau faib cov tsiaj rau hauv peb pawg: ib pawg tswj hwm ib txwm muaj, IMQ- pab pawg tsim qauv, thiab pab pawg kho mob tau txais calcitriol. Ua raws li IMQ induction, cov qauv thiab cov pab pawg kho mob pom cov psoriasis sib txawv -zoo li qhov txhab. Remarkably, calcitriol kev kho mob nyob rau hauv cov pab pawg neeg cov tshuaj zoo heev ameliorated cov tawv nqaij txawv txav. Kev soj ntsuam cov qhab nia thoob plaws txhua pab pawg qhia qhov sib txawv tseem ceeb, qhia txog qhov ua tiav ntawm tus qauv.
Kev soj ntsuam Psoriasis
Pathological Insights thiab Clinical Relevance
Txhawm rau tshawb xyuas ntxiv txog kev mob psoriasis, peb tau sau cov qauv ntawm daim tawv nqaij ntawm ntau theem: ua ntej-induction, induction, post-induction, kho, thiab tom qab- kho. Cov kev tshawb fawb histological tau qhia pom cov yam ntxwv ntawm psoriasis hauv cov qauv thiab kev kho mob, suav nrog cov kab mob ntawm tes infiltration, parakeratosis, thiab hyperkeratosis. Qhov tseem ceeb, cov tsos mob hauv pab pawg kho mob tau zoo tuaj tom qab kev tswj hwm calcitriol, raws li kev tshawb pom los ntawm histopathological.
Histopathology tshawb pom: Tom qab IMQ tshuaj pleev ib ce rau 21 hnub
thiab daivobet kev kho mob rau 7 hnub: txo cov thickness ntawm epithelium (stratum spinosum),
txo inflammatory cell infiltration hauv qab epidermis, txo scaling,
Transforming Preclinical Drug Research
Tus qauv cynomolgus liab psoriasis tsim los ntawm Prisys Biotech zoo rov ua dua cov yam ntxwv tseem ceeb ntawm tib neeg psoriasis, ua rau nws lub platform muaj zog rau kev tshuaj xyuas tshuaj preclinical thiab kev tshawb fawb kho. Cov qauv no txuas rau qhov sib txawv ntawm qhov kev tshawb pom thiab kev siv tshuaj kho mob, ua kom qhov kev tshawb pom tshiab ntawm kev kho mob rau cov kab mob nyuaj no.
TxogPrisys Biotech
Prisys Biotech yog ib lub chaw muab kev pabcuam tseem ceeb ntawm cov kev pabcuam tshawb fawb txog kev kho mob nrog rau kev tsom mus rau cov qauv tsis yog -tib neeg primate. Lub npe nrov rau peb cov kws tshaj lij hauv kev tsim kab mob- cov qauv tshwj xeeb, peb pab txiav- kev tshawb fawb ntug hauv kev tiv thaiv kab mob, CNS mob, kab mob hematological, thiab kab mob dermatology. Pebtiag - lub sij hawm imaging platforms, advanced pathology muaj peev xwm, thiabAI-tsav kev ntsuas kev coj cwj pwmteem peb sib nrug los ua ib tug ntseeg tus khub rau tshuaj innovation. Los ntawm kev sib xyaw ua ke, kev tshawb fawb nruj, thiab kev ua raws li kev coj ua, Prisys Biotech tseem ua rau muaj kev nce qib hauv cov tshuaj txhais lus.
