Txhim kho ntshav ntshav thiab ntshav txhaws kev kho tshiab nrog Cynomolgus Monkey MCAO Qauv - Prisys Txheej xwm

Stroke, tseem hu ua cerebrovascular kev huam yuaj (CVA), yog ib qho mob hlwb tsis ua hauj lwm los ntawm ob qho kev cuam tshuam los yog rupture ntawm cerebral ncig. Muaj ob hom mob stroke: ischemic thiab hemorrhagic. Ntawm cov no, ischemic stroke, uas tshwm sim los ntawm kev txo cov ntshav txaus vim thrombosis lossis embolism, yog hom ntau dua. Stroke tseem yog ib qho ua rau muaj kev tuag thiab kev tsis taus thoob ntiaj teb, ua rau muaj kev nyuaj siab thiab lub nra hnyav rau pej xeem kev noj qab haus huv.

Comparing T2-weighted MRI Imaging in Humans, Cynomolgus Monkeys, and Rats — Sib piv T2-weighted MRI Imaging nyob rau hauv tib neeg, Cynomolgus Monkeys, thiab nas

Tus qauv tsiaj muaj kev vam meej tuaj yeem sim ua cov txheej txheem pathological ntawm tib neeg cov kab mob, muab cov kws tshawb fawb nrog cov cuab yeej tseem ceeb los tshawb txog kev kis kab mob thiab ntsuas kev kho mob zoo. Vim nws cov noob caj noob ces siab, anatomical, thiab physiological zoo sib xws rau tib neeg, cynomolgus liab tau dhau los ua tus qauv tsiaj zoo tshaj plaws rau kev tshawb fawb neuroscience thiab mob stroke. Piv nrog rau cov qauv tsiaj me uas siv ntau dua li nas lossis nas, lub hlwb qauv ntawm cov liab zoo ib yam li tib neeg, tshwj xeeb tshaj yog nyob rau hauv kev faib ua feem ntawm cortex thiab dawb teeb meem. Qhov no ua rau muaj kev cuam tshuam ntau dua ntawm tib neeg kev kis kab mob thiab cov lus teb kho mob. Tsis tas li ntawd, lub cev loj dua ntawm cov liab tso cai rau qhov tseeb ntau dua - lub sijhawm ntsuas, cov txheej txheem phais, thiab kev siv tshuaj, ua kom muaj qhov tseeb thiab tswj tau ntau dua hauv kev tshawb fawb. Yog li ntawd, tus qauv cynomolgus liab muaj qhov zoo tsis tuaj yeem hloov pauv hauv kev simulating tib neeg cov kab mob.

Prisys Biotech's MCAO Model

Prisys Biotech CovMiddle Cerebral Artery Occlusion (MCAO) qauvyog tus qauv tsiaj zoo rau simulating ischemic stroke. Los ntawm kev tswj hwm qhov chaw occlusion thiab lub sijhawm ntev, tus qauv no tau rov ua dua cov txheej txheem pathological ntawm tib neeg mob stroke, muab cov cuab yeej tseem ceeb rau kev kawm cov txheej txheem mob stroke thiab cov tswv yim kho mob.

An Optimal Animal Model of Ischemic Stroke Established by Digital Subtraction Angiography-Guided Autologous Thrombi in Cynomolgus Monkeys

DSA-guided cerebral angiography and real-time imaging of MCAO in cynomolgus macaque — DSA-kev qhia txog kev mob hlwb thiab lub sijhawm tiag tiag ntawm MCAO hauv cynomolgus macaque

Tam sim no, Prisys Biotech tau tsim kom muaj kev paub tabcynomolgus liab MCAO qauv . Cov ntaub ntawv ntsig txog tus qauv no tau luam tawm hauv phau ntawv xov xwmFrontiers hauv Neurology, thiab tus qauv tau ua tiav kev txhawb nqa kev soj ntsuam kev ua tau zoo ntawm ntau yam tshuaj tshiab.

Cov ntsiab lus tseem ceeb ntawm Clinical Endpoints

Vascular Reperfusion: Kev ntsuam xyuas siv CTA, MRA, thiab CTP imaging los ntsuam xyuas vascular recanalization.
Kev hloov pauv ntawm ischemic hauv lub paj hlwb: Cov cheeb tsam mob hlwb ischemia raug soj ntsuam siv MRI thiab DWI ib ntus.
Cov txiaj ntsig ntawm tus cwj pwm:Cov qhab nia tsis txaus ntawm lub paj hlwb raug kaw rau 7 hnub sib law liag tom qab- kev phais, tsom rau kev nco qab, lub cev muaj zog, thiab kev sib koom tes.
Brain Tissue Staining:TTC staining yog siv los txheeb xyuas thaj chaw infarct, ntsuas qhov twg thiab qhov hnyav ntawm lub hlwb puas.

Summary of CT Images Comparing Two MCAO Model Groups — Cov ntsiab lus ntawm CT duab piv ob pawg MCAO qauv
Hauv pab pawg sim, CTA scans ua nyob rau ntawm 24 teev thiab hnub 7 tom qab- kev phais tau pom tias rov ua dua hauv MCA thiab nws cov ceg ntoo, thaum tsis pom qhov pom ntawm MCA tau pom hauv pawg tswj hwm. Qhov sib txawv tseem ceeb tau sau tseg hauv CTP scans ntawm ob pawg (qhia los ntawm cov xub dawb).

Qauv Zoo

High Clinical Relevance: Tus qauv siv autologous venous thrombi los ntxias MCA occlusion, simulating hom mob stroke feem ntau pom nyob rau hauv cov chaw kho mob, yog li zoo xav txog cov pathogenesis thiab kho cov lus teb nyob rau hauv tib neeg mob stroke.
Cov txheej txheem Minimally Invasive:Vascular catheterization nyob rau hauv DSA kev taw qhia kom paub tseeb thrombus tso nrog tsawg kawg ntawm kev phais mob, txo cov teeb meem tom qab phais thiab txhim kho kev ntseeg siab ntawm kev sim.
High Reproducibility thiab Stability:Tus qauv qhia tau hais tias muaj kev vam meej siab, muab cov txiaj ntsig zoo ib yam thiab lub hauv paus ruaj khov rau kev tshawb fawb tom ntej.
Comprehensive Imaging Evaluation: Ntau-dimensional tiag- lub sijhawm saib xyuas sivCTA, CTP, thiab MRImuab kev ntsuam xyuas meej thiab meej ntawm vascular recanalization thiab ischemic puas rau cov ntaub so ntswg hlwb.
Tsawg Mortality Rate: Cov txheej txheem minimally invasive ua rau muaj kev raug mob tsawg dua, ua kom muaj kev nyab xeeb ntawm cov tsiaj thaum phais. Kev ua raws li cov qauv kev kho mob txhim kho kev muaj sia nyob, ua tus qauv tsim nyog rau kev tshawb fawb ntev -.
Ultra-Kev Ntsuas Phase Dose Ntsuas: Cov qauv no tso cai rau kev soj ntsuam cov tshuaj ntau npaum li cas thiab kev ua tau zoo thaum lub sijhawm ultra- mob stroke tom qab pib mob stroke.

Neurological Deficit Scores on Day 7 Post-Surgery — Neurological Deficit Scores Hnub 7 Tom Qab-Kev phais. Tom qab 7 hnub ntawm kev kho mob thrombolytic, cov qhab nia ntawm neurological deficit nyob rau hauv pab pawg neeg sim pom qhov txo qis piv rau pawg tswj hwm. Cov ntaub ntawv raug nthuav tawm raws li txhais tau tias ± tus qauv sib txawv. Lub axis ntsug sawv cev rau cov qhab nia neurological deficit, thiab kab rov tav axis sawv cev rau lub sijhawm tom qab-infarction.

Nthuav mus rau Hemorrhage thiab Coagulation Kab Mob Model

Ntxiv rau nws cov kev txawj ntse hauvcentral paj hlwbthiab cov qauv ischemic stroke, Prisys Biotech kuj tsom rau kev kawm cov ntshav-txog kev mob, tshwj xeeb tshaj yog nyob rau hauv cov kab mob hemorrhagic thiab thrombotic. Peblos ntshav thiab cov kab mob ntshav khov encompass ib tug ntau yam ntawm tej yam thiab tsis tshua muaj pathological mob, nrog rauHemophilia A, A-V Shunt, Intracerebral Hemorrhagic Stroke, thiab ntau dua. Cov qauv no muab qhov kev sim siab ntseeg siab rau kev tshawb fawb txog cov txheej txheem hauv qab ntawm cov kab mob no thiab txhim kho cov txheej txheem kho tshiab, ntxiv dag zog rau Prisys Biotech tus kws tshaj lij kev ua haujlwm hauv preclinical loj-txoj kev tshawb fawb tshuaj tsiaj.

Prisys Biotech tseem tau cog lus rau pioneering txoj kev tshawb fawb tshiab los daws cov teeb meem thoob ntiaj teb los ntawm kev mob stroke thiab lwm yam kab mob. Peb yuav txuas ntxiv ntxiv dag zog rau kev sib koom tes nrog cov neeg koom tes hauv kev lag luam txhawm rau txhawm rau txhawm rau kho cov kev txhais lus ntawm kev tshawb fawb thiab thaum kawg xa cov kev kho mob zoo dua rau cov neeg mob.

Cov ntaub ntawv
Ye J, Shang H, Du H, et al.Tus Qauv Tsiaj Zoo Tshaj Plaws ntawm Ischemic Stroke Tsim los ntawm Digital Subtraction Angiography-Guided Autologous Thrombi hauv Cynomolgus Monkeys.Frontiers hauv Neurology. 2022; 13:864954. doi: 10.3389/fneur.2022.864954.

Hais txog Prisys Biotech

Prisys Biotechnologies Co., Ltd. tau lees paub los ntawm AAALAC, tshwj xeeb hauv kev tshuaj xyuas cov tshuaj preclinical thiab translational thiab kev tsim tshuaj tshiab technology. Kev tsom mus rau cov tshuaj tsiaj loj thiab kev tshawb fawb txog kev ua tau zoo, Prisys Biotech muaj ntau yam kev pabcuam, suav nrog cov qauv kab mob, pharmacodynamics, kev soj ntsuam kev nyab xeeb, kev tshawb fawb biomarker, thiab kev siv lub tshuab siv tsis siv -tib neeg primates xws li cynomolgus liab. Prisys Biotech tau tsim lub chaw kho tshuaj txhais lus uas ua tau raws li cov qauv kev lag luam kws tshuaj thiab tau tsim kev koom tes ntev ntev nrog rau cov tuam txhab tshuaj, cov tuam txhab biotech, thiab cov tsev kawm ntawv thoob ntiaj teb.

Kawm ntxiv

DSA Digital Subtraction Angiography of Prisys Biotech