NHP mob qauv rau kev txhais cov khoom siv tshuaj|Prisys biotech - prisys cov xwm txheej

Qhov mob yog ib lub cev muaj sia thiab kab mob pathological, sawv cev rau cov tsos mob tseem ceeb hauv ntau tib neeg cov kab mob. Kev tsim kho cov tsiaj uas txhim khu kev qha uas yog qhov tseeb ntawm cov neeg mob tib neeg txoj kev mob yog qhov tseem ceeb rau kev ua tau zoo hauv kev siv tshuaj.Khiys Biotech, ib tug coj loj {{|}}} tsiaj preclinical cro, tau ua ib qho kev nce qibtsis - human primate (NHP) qhov kev tshawb fawb lub platformSiv cynomolgus macaques. Kev sivevAi -} Powered Cwj Pwm Analytics, siab {- daws teeb meem kev ua yeeb yam, thiab neurophysiological cov tswv yim, Prisys muab cov ntaub ntawv tseeb, reproupucible cov ntaub ntawv kom nrawm acceler- kev ntsuas tshuaj yeeb, thiab kev txheeb xyuas kev ua tau zoo.

Cov Qauv Cynomolgus Mob Qauv

1. Capsaicin -} ua rau tawv nqaij vasodilation qauv

Mechanism:Intradermal capsaicin txhaj cov triggers nyob rau vasodilation npaum li cas, pab ua lub hom phiaj mob siab.

Cov Cuab Yeej Ntsuas:

Laser Specks ua kev ntsuam xyuas (LSCI)kom muaj nuj nqis hloov pauv ntawm daim tawv nqaij ntshav ntws thiab o -}Flare cheeb tsamnyob rau hauv lub sijhawm tiag tiag.

Bold Ua Haujlwm MRI (FMRI)Txhawm rau qhia Central mob hlwb cov kev mob tau teb rau capsaicin kev txhawb zog.

Kev siv tau:Pre6 - kev kho nrog Lidocaine Kho Kom Zoo Li Cas OnLresses Vasodation, Qhia Qauv Txheej Txheem Kev Cuam Tshuam.

Tail withdrawal test for capsaicin challenge — Tsov tus tw tshem tawm kev sim rau cov kev sib tw hauv capsaicin

2. Il-31-induced pruritus qauv

Daim Ntawv Thov:Cov qauv khaus -}} khaus dermatitis, qhov twg yuav tsum khaus khaus yog qhov mob- cuam tshuam zoo nkauj.

Tshuab: Cwj Pwm Coj Cwjelatlas® Ai - Raws li nhp kev txheeb xyuas tus cwj pwmUa ntau -} Lub 3D skelteral kev tsim kho kom muaj objection, tag nrho lub sijhawm luv, thiab}}}}}} Duration khawb.

3. Neuropathic Mob Qauv (hauv Kev Loj Hlob)

Spinin Verve Ligation (SNL) qauv:Simulates cov leeg hlab ntsha -}} kev mob neuropathic.

Kev Siv Tshuaj Kho Mob -}} induced peripheral neuropathy (Xov Xwm:Suav nrogoxaliplatin -} induced mobTxhawm rau kawm kev mob neuropathic cuam tshuam nrog kev kho mob cancer.

Nkag siab ntau -} qhov kev ntsuas seem

Khiys Biotech sib xyaw ua ke, cov kev xav, kev ua yeeb yam, thiab electrophysiological kawg kom ua tiavrob muaj zog, siab - kev ntsuas mob qhov kev sim.

Kev ntsuas coj cwj pwm

Tawb -} kev soj ntsuam:Kev soj ntsuam kev ua si, qab los noj mov, kev coj dawb huv, kev coj txawv txawv, thiab cov yeeb yam ntawm cov tshuaj {{}} sib xws.
Tshuav tus cwj pwm tsis zoo:Suav nrog kev coj tus cwj pwm tshwj xeeb thiab24-teev kev ua si / pw tsaug zog voj voog.
Quantitative Tshuaj Ntsuam Xyuas:Duration {{0- Raws li kev ntsuas (t1+2 t 2+3 t3) rau lub hom phiaj kev ntsuas kev siv mob siab.
Lub Cev Muaj Zog Ntsuas:Cov suab leeg me nyuam qhab nia, pub dawb - txav3D kev tshuaj xyuas, thiab treadmill gait tsom xam.

Spontaneous pain-behavior analysis — Spontaneous mob - kev tshuaj xyuas tus cwj pwm

Kev kuaj mob

Neeg kho tshuab tag nrho (PAM):Daim ntawv thov ntsuas siab kom ntsuas cov tshuab kev mob tshuab hluav taws xob.
Thermal rhiab heev xeem:Thaum tshav kub kub thiab txias {- dej immersion los ntsuas thermal hyperalesia thiab tag nrho.
Mob taub txias:Kev ntsuam xyuas ntawm Post -} scorical txias anlocynia.
SOOSSE KERTATION VELOCITY (SCV):Kev ntsuas ntawm txoj hlab ntshav txoj hlab ntshav, latency, thiab amplitude.

Advanced Imwing thiab Neurophysiology

Tiag - lub sij hawm mri (IMRI) nrogConvection -} kev hloov pauv (ced):Siv covMRI -} coj cov zaub mov nojRau sub - millimeter preciseter preciseter precision cov cheeb tsam ntawm cov cheeb tsam tshwj xeeb thiab cns- Tsom rau kev kho mob.
Electroencephalography (EEG):Kev ntsuam xyuas cov tshuaj mob nkeeg ntawm lub hlwb ua si hauv aum.
High - tebMRI & CT:Cov ncauj lus kom ntxaws anatomical thiab pathological kos duab ntawm lub hlwb thiab lwm cov plab hnyuv siab raum, nrog cov post {}}-}}}} Tsom rau kev faib tshuaj.

Cov Ntsiab Lus Zoo ntawm prisys Biotech's NHP Qhov Kev Tshawb Fawb Kev Tshawb Fawb

Nkag siab ua qauv qauv insorfolio:Covering acute, chronic, neuropathic, and itch-associated pain conditions.
Ai - Cov ntaub ntawv driver driven li cas:TusCwj pwm Cegatatlas® SystemMuab cov cim tsis muaj cim, hom phiaj 3D tus cwj pwm paub tseeb.
Soj ntsuam kev tshaj lij:Coj los ntawm cov kws kho mob qub thiab cov kws kho mob raws caij nyoog nrog kev ntsuas tib neeg thiab kev tshuaj ntsuam xyuas mob.
State-of-the-Art Facilities:4,000 m n m n en -}}}} Lub tsev tshawb fawb lub tsev nyob rau 500, nrog rau kev phais mob tsev nyob.

Tag

Nrog nws cov kev sib txuas platform sib txuasSiv tau NHP cov qauv kev mob, cov duab siab, {{{{{}} Raws kev soj ntsuam, thiab kev txawj ntse, Prisys biotech yog ib tus khub ntseeg tau rau cov tuam txhab uas muag khoom tsom mus rau kev tsim kho kom zoo dua thiab kev mob zoo dua. Los ntawm bridging qhov sib txawv ntawm cov kev tshawb fawb ua ntej thiab chaw kuaj mob, cov menyuam yuav pab saib xyuas kom nrawm rau tus neeg mob.