Cov kab mob ua pa {{0} Xws li muaj tus kab mob ntsws sib deev (dogronary fibrosary- Nrog kev xaiv tsa ib puag ncig ib puag ncig, cov neeg laus, thiab cov kev tshawb fawb muaj txiaj ntsig zoo dua qub tsis tau muaj kev txhawj xeeb dua.
Hauv kev teb rau cov kev cov nyom no,Khiys BiotechTau tsim kom muaj zog, kev tshawb fawb platform muaj mob siab rau nce qib thiab kev kho mob ua pa. Tshwj xeeb hauvtsis - hume hume primate (NHP)Kab Mob Kab MobThiab kev xa cov tshuaj tshaj tawm kev siv tshuab, cov neeg Khwv sawv ntawm qhov kev tshawb fawb ua pa ua kom tiav.
Tsom ntsoov rau Copd qauv: simulation tiag tiag simulation rau tshuaj uas muaj kev cuam tshuam tshuaj
COPD yog tus kab mob Airway muaj zog ua ntej los ntawm Long -} kev haus luam yeeb thiab ib puag ncig kev haus luam yeeb. Khovtsis - human primatepd qauvyog ntxias ntawm cov pa luam yeeb, qog cov txheej txheem ntau tshaj plaws uas pom hauv tib neeg cov neeg mob. Cov qauv no yog qhov tseeb ntawm cov tsos mob tseem ceeb xws li cov pa hluav taws xob, thiab cov nqaij kho kom zoo nkauj rau kev sim ua ntej thiab kev siv yeeb tshuaj.
Nrog kev nce qib nruam hauv cov qauv ua kom zoo dua thiab cov prisys muab cov kev kho mob kho mob uas yuav ua pa cov kab mob ua pa.
Kev ua haujlwm zoo rau cov qauv ua pa: kev tshawb fawb nruj, dav dav siv
Tshaj li Copd, prisys muaj tag nrho cov suite ntawm cov pa ua pa qauv ua kom haum rau cov kev tshawb fawb ntau yam:
Mob hawb pob / Atopic Dermatitis cov qauv: Inducles los ntawm ovalbumin (ova) lossis cov plua tshauv hauv tsev kom luam cov pa pa hluav taws. Cov yam ntxwv tseem ceeb suav nrog:
- Kev tsis taus kev tiv thaiv thiab kev nqus tau cov nyom tib neeg mob hawb pob.
- Cov cim xws li nce cov pa pa ntxiv, xws li infiltration hauv lub ntsws thiab bronchi, thiab siab dua TH2 cytokines.
- Cov pa hyperresponitessess nrog fluticasone.
- Kev ntsuas kom paub tseeb los ntawm Acetylcholine (ACH) PC50 kuaj.
- BronChoalvololle Lag Luam Flu (Balf) tsom xam, suav nrog IL- 8, il-8, tnf- nrhiav kom tau thiab cell suav.
- LUNG Functuab ntsuas suav nrog rau yuam kev tseem ceeb (FVC) thiab kev tawm tsam (RL).
- Txhawb tau dual induction ntawm hawb pob thiab igic dermatitis.
Kws Mob Siab Mob Mob Taub Hau: Puas yog ntawm LPS lossis tshuaj lom neeg (piv txwv li, diluted hcl) los tsim cov tshuaj needrophilic ne, sim ua kom mob ntsws lossis mob ntsws.
Pulmonary Fibrosis Qauv: Tsim los ua kom pom cov mob ntsws uas muaj mob siab (IPF), yooj yim} ntev mechanistic thiab kho cov kev tshawb fawb.
Ua tsis haum rhinitis & BSL-2 pathogen Tus Qauv: Pab kom nrhiav kev kawm tawm ntawm cov lus teb tsis muaj zog thiab cov tshuaj tiv thaiv kev ua tau zoo hauv cov kev tswj hwm biosafety.
Lub Tshuab Khoom Siv Hluav Taws Xob: Lub Hom Phiaj, Muaj Zog, thiab Ntau Yam
To taub tias kev ua tau tshuaj muaj txiaj ntsig ntawm cov kev coj ua, cov neeg loj hlob muaj cov thev naus laus zis ntawm kev kho mob ua pa:
- Inhalation Menyuam: Tsis yog -} {- Tus phooj ywg txoj kev tsom mus rau lub ntsws ncaj qha.
- INTRA - bronchial tswj hwm: Xa tshuaj rau cov cheeb tsam bardions, ua kom zoo tshaj plaws hauv zos ua tau zoo thaum kev txo qis kev ua haujlwm.
- IntratrAtracheal tswj hwm: Kev xa khoom sai thiab ua haujlwm hauv zos thaum lub sijhawm xwm txheej ceev lossis kev saib xyuas mob hnyav.
- Tus caj qaum ntawm cov hau kev no yog tusAerogen Nank Polulation, ib lub xeev - - - ech- Effectiency Aerosol Cov Khoom Noj Kom Zoo Raws Li Cov Khoom Noj Kom Zoo Raws Li Cov Khoom Noj Uas Muaj Peev Xwm Kom Zoo Raws Li Cov Khoom Noj Uas Muaj Peev Xwm Kev Ua Haujlwm Thoob Plaws Thoob
- Ntxiv mus, prisys yog nquag tsim ibN2b (lub qhov ntswg - rau -} lub hlwb) platformtsom ntawm txhim kho nruab nrab central leeg system tshuaj.
Kev sib xyaw ua ke Pulmonary Lub Peev Xwm: ib {-} Tsis txhob muaj kev txhawb nqa scientific
Khov cov neeg ua pa tawm tsam platform sib koom ua ke sab saum toj - Tier technologies txhawb nqa:
- NHP Biosafety Chaw: Nruab nrog ib qho tshwj xeeb ua pa ua pa rau siab - muaj cov kev tshawb fawb muaj.
- Soj ntsuam imjecting: CT kev xav ua kom ntsuas kev pab them nqi kho mob hauv IPF qauv, xaub ntim tsom xam, thiab cov leeg ntsws ntsws ntsws Cta.
- Lung kev ua haujlwm kuaj: Xws li kev xeem PC50, FVC, thiab cov pa tawm tsam tiv thaiv.
- Ntsau Kev Ntsuam Xyuas: Quatitative ntsuas ntawm cov cim ntsuas pa thiab cov khoom siv cell, tseem ceeb rau kev ua kom mob ntsws mob ntsws.
- Tsev livpathology: Kev tshuaj xyuas ntawm H & E, PAS, thiab Immunohistochemistry (IHC) staining.
- Nyob rau hauv vitro assays: Ntws cytometry, kev tsom xam sib zog, thiab kev sib koom tes xws li LC - ms, elisa, thiab Elispot.
Khej cov pab pawg ua kom paub cov ntawv me me
Xaus: Tus khub nrogPrisysTxhawm rau kom nrawm ua pa hluav taws xob
Tsav los ntawm kev tsim kho tshiab, Precision, thiab kev tshawb fawb zoo, prisys yog tus neeg muaj txiaj ntsig rau cov tuam txhab uas ntseeg tau rau cov tuam txhab uas ntseeg tau rau cov kab mob ua pa. Nws muaj txhij txhua tsis yog {{1} human pressions, thiab xaus}} {} {} {} {} {} {} {} {} {
Txawm hais tias koj tau tshawb txog CopD, mob hawb pob, mob ntsws ntsws, lossis cov kws khomob uas yuav tsum ua pa tawm hauv tsev kho mob.
