Cov kev tshawb fawb ADC pharmacokinetic (PK) ua lub luag haujlwm tseem ceeb hauv kev txhim kho kev ua tiav ntawm cov tshuaj tiv thaiv kab mob -tshuaj conjugates (ADCs), uas muab cov tshuaj tiv thaiv kab mob, ib qho txuas, thiab cov cytotoxic payload. Vim tias txhua yam cuam tshuam rau cov tshuaj muaj kev ruaj ntseg, kev ua tau zoo, thiab kev nyab xeeb, PK cov kev tshawb fawb tau tsim los ua tus cwj pwm li cas ADCs raug faib, metabolized, thiab tshem tawm hauv vivo. Tsis zoo li cov qauv biologics, ADC PK kev ntsuam xyuas yuav tsum tau saib xyuas ntau yam kev tshuaj ntsuam xyuas- suav nrog tag nrho cov tshuaj tiv thaiv kab mob, cov tshuaj tiv thaiv kab mob sib txuas, kev them nyiaj sib txuas, kev them nyiaj pub dawb, thiab cov metabolites- kom nkag siab zoo txog kev sib raug zoo ntawm kev siv tshuaj, kev kho mob zoo, thiab tshuaj lom.
Cov kev txiav txim siab tseem ceeb rau ADC PK cov kev tshawb fawb, suav nrog kev xaiv cov kev ntsuas tsim nyog, cov qauv tsiaj, kev siv tshuaj noj, thiab cov ntsiab lus tshuaj tshuaj lossis tshuaj lom neeg. Siv trastuzumab emtansine (T-DM1) ua piv txwv, nws qhia tau hais tias PK kev soj ntsuam zoo li cas tuaj yeem nthuav tawm cov yam ntxwv tseem ceeb xws li kev ruaj ntseg tshuaj, kev tso tawm, tshem tawm, thiab cov koob tshuaj sib npaug, thaum kawg txhawb kev siv tshuaj kom zoo thiab kev kho mob.
Thaum kawg, Prisys Biotechnology's kev koom ua ke ADC PK platform, uas sib txuas cov thev naus laus zis analytical, suav nrog LC-MS/MS, immunoassays, radiolabeling, flow cytometry, imaging techniques, thiab PK/PD modeling. Cov peev txheej no ua rau muaj kev paub txog tus yam ntxwv ntawm ADC cov neeg sib tw thiab txhawb kev txiav txim siab paub tseeb- ua thoob plaws hauv kev kho mob thiab kev kho mob.
