Engineered exosomes tau tshwm sim los ua ib qho kev cog lus rau kev xa tshuaj rau lub hauv paus paj hlwb (CNS) mob. Raws li ib txwm muab los ntawm cov hlwv extracellular, exosomes muaj biocompatibility zoo heev, tsis muaj kev tiv thaiv kab mob, thiab muaj peev xwm thauj cov proteins, nucleic acids, thiab lwm yam khoom kho mob. Los ntawm bioengineering, exosomes tuaj yeem ua kom zoo dua los txhim kho kev thauj khoom, kev ruaj ntseg, lub hom phiaj kev ua tau zoo, thiab lub sijhawm ncig, ua rau lawv cov neeg nqa khoom txaus nyiam rau tom ntej - tiam tom ntej kho.
Ib qho txiaj ntsig zoo tshaj plaws ntawm kev tsim cov exosomes yog lawv lub peev xwm los kov yeej cov ntshav - hlwb barrier (BBB). Tsis ntev los no cov kev tshawb fawb preclinical tau pom tias muaj kev vam meej ntawm kev kho cov tshuaj molecules, suav nrog siRNA thiab miRNA, mus rau lub hlwb hauv cov qauv ntawm Alzheimer's disease, Parkinson's disease, mob stroke, thiab lwm yam kab mob neurological. Cov kev nce qib no qhia txog qhov muaj peev xwm ntawm exosome-raws li kev kho mob kom pab tau kev kho mob thaum txo cov kab mob toxicity.
Kev txhais lus kho mob tau zoo yuav tsum muaj kev ntsuam xyuas ua ntej, suav nrog biodistribution, pharmacokinetics/pharmacodynamics (PK/PD), kev nyab xeeb, kev tiv thaiv kab mob, thiab kev tshawb fawb txog kev ua tau zoo hauv cov qauv tsiaj. Cov chaw kho mob muaj zog muaj zog, tshwj xeeb tshaj yog cov koom nrog tsis yog - tib neeg cov kev tshawb fawb primate thaum tsim nyog, muab cov ntaub ntawv tseem ceeb los txhawb kev tswj hwm kev xa tawm thiab ua kom muaj kev txhim kho ntawm cov kws kho mob exosome rau CNS kab mob.
Prisys Biotech - Koj tus khub hauv Advancing Exosome Therapeutics
Engineered exosomes tuav lub peev xwm loj heev los hloov pauv kev xa tshuaj, tshwj xeeb tshaj yog rau cov teeb meem nyuaj CNS. Lawv lub peev xwm los tiv thaiv cov khoom thauj, txhim kho bioavailability, txo toxicity, thiab lub hom phiaj tshwj xeeb cov ntaub so ntswg, suav nrog kev hla cov ntshav - hlwb teeb meem, ua rau lawv lub platform zoo nkauj heev. Txawm li cas los xij, lawv txoj kev ua tiav kev kho mob txhais lus hinges ntawm cov yam ntxwv ntawm preclinical robust, nrog rau kev nyab xeeb thiab kev ntsuas kev ua tau zoo hauv cov qauv tsiaj.
Prisys Biotechyog nruab nrog cov kws tshaj lij thiab cov qauv NHP siab heev los txhawb kev txhim kho preclinical ntawm lub tshiab exosome-raws li kev kho mob. Peb muab cov kev pab cuam, los ntawm biodistribution thiab PK/PD cov kev tshawb fawb rau kev soj ntsuam toxicology, los pab de- pheej hmoo rau koj cov neeg sib tw exosome thiab ceev lawv txoj hauv kev mus rau qhov chaw kho mob.
Hu rau Prisys Biotechtxhawm rau tshawb xyuas seb peb cov kev pabcuam preclinical tuaj yeem ua rau koj qhov kev kho mob exosome.
