Atopic dermatitis NHP qauv

Atopic Dermatitis (Ad)yog ib tug mob ntev, rov ua kom cov tawv nqaij tsis sib haum xeeb tsis zootus pruritus, Emerhema, thiab Epidermal Teeb Meem Dysfunction. Nws yog tus kabmob multifactorial muaj kev pom caj ces, tsis muaj zog dysregulation, thiab cov chiv keeb ib puag ncig. Kev txhawb nqa thoob ntiaj teb ntawm kev tshaj tawm loj hlob, cuam tshuam txog li 20% ntawm cov menyuam yaus thiab 10% ntawm cov neeg laus, nra hnyav. Ad pathogenesis cuam tshuam nrog kev sib cuam tshuam nrog keratinocytes, tiv thaiv kab mob, thiab lub microbiome, ua rau nws muaj kev nyuaj siab tseem ceeb rau kev kho.

Ua rau:

Cov pathogenesis ntawm ad yog multifaceted:

1. Epidermal Teeb Meem Dysfunction: sib hloov hauv Filaggrin (Fleg) Gene Impair Lub teeb meem, kev ua yeeb yam ntau rau cov ua xua thiab tsis txaus ntseeg.
2. Lub cev tsis muaj zog: Ua kom cov lus teb tsis zoo ntawm hom tshuaj tiv thaiv kab mob 2}
3. Microbiome Dysbiosis: Dominance Aureus exacerbates o thiab cuam tshuam cov tawv nqaij antostasis.
4. Cov chiv thawj ib puag ncig: Cov ua ke, cov pa phem, thiab kev ntxhov siab pab txhawb rau kab mob exacerbation. Cov kev sib tshuam no cuam tshuam rau qhov tseem ceeb ntawm cov qauv kev ua yeeb yam rau kev kawm ad pathogenesis thiab ntsuas kev kho kev tiv thaiv kev cuam tshuam.

Kev tshawb fawb tsim qauv thiab chaw kuaj mob

Prisys biotech's nHP Ad qauv yog meticulously tsim los txhawb tib neeg cov kab mob thiab muab cov kev pom zoo:
 

Kev kawm tsim:

 

• Lub rhiab uas siv ovalbumin) nrog txhuas adjuvant los ntawm intraperntoneal, subcutaneous, lossis aerosol txoj kev.

• Txij nkawm ntawm kab mob phenotype los ntawm boosters thiab cov kev sib tw ua kom pom kev ua kom tiav ad zuj zus.

• Kev siv tau los ntawm kev kuaj mob hauv kev sim thiab saib xyuas cov phiajcim uas pom.

 

Soj ntsuam endpoints:

 

1.ClIliner qhab nia:Erythema, scaling, pruritus, thiab lesion loj (yoog los ntawm Easi nplai).

2.Yhistopathological tsom xam:Kev ntsuam xyuas ntawm Epidermal hyperplasia, mob cell infiltration, thiab mast cell ua si.

3.Biomarmer Quantification:Qib ntawm serrum ige, ur -4}},}}, thiab ifn-.

4.Behavioral soj ntsuam:Tus pruritusZaus thiab mob hnyav.

5.sk microbiome tsom xam:Cov zej zog muaj txiaj ntsig.

6.pulmonary functions Ntsuam Xyuas:Rau cov neeg sib koom tes ua kom mob hawb pob, cov lus teb carmonary rau acetylcholine (ACH) raug ntsuas.

 

 

Tiv Tauj Peb Rau Cov Lus Qhia Ntxiv

 

 

Cim npe nrov: atopic dermatitis NHP qauv, tshawb fawb, kawm, kev kho mob noob