Precision Immunology rau Autoimmune Drug Discovery: Prisys Biotech's Th17-Driven NHP Model Platform
Kev nkag siab thiab hloov kho txoj hauv kev T pab 17 (Th17) tseem yog ib qho kev sib tw tseem ceeb hauv kev txhim kho kev kho mob rau cov kab mob autoimmune thiab mob ntev. Prisys Biotech tau tsim muaj kev mob siab rautsis yog-neeg primate (NHP) qauvplatform tsim los txhawb thiab ua tus yam ntxwv Th17-tsav lub cev tiv thaiv kab mob hauv cynomolgus liab. Lub platform no muab cov cuab yeej txhais lus tseem ceeb rau kev ntsuam xyuas cov kev kho tshiab uas tsom rau IL-17 / IL-23 axis thiab lwm txoj hauv kev cuam tshuam hauv Th17 dysregulation.
Kev Tshawb Fawb Txog Kev Tshawb Fawb: Vim Li Cas Th17 Tseem Ceeb
Th17 hlwb thiab lawv cov cytokines kos npe -tshwj xeeb tshaj yog IL-17A-ua si ob lub luag haujlwm hauv kev tiv thaiv tus tswv thiab kab mob. Thaum tseem ceeb rau kev tiv thaiv cov kab mob extracellular thiab fungi, ntau dhau los yog dysregulated Th17 kev ua ub no ua rau cov kab mob ntawm cov kab mob xws li psoriasis, ankylosing spondylitis, rheumatoid mob caj dab, thiab ntau yam sclerosis.
Cov qauv nas yog siv dav, tab sis feem ntau tsis tuaj yeem tsim cov yam ntxwv tseem ceeb ntawm tib neeg Th17 biology, txwv lawv qhov kev kwv yees tus nqi hauv kev tshawb fawb kev txhais lus. Muab lub cev tiv thaiv kab mob zoo sib xws ntawm cynomolgus liab thiab tib neeg, ib qhoNHP-raws li Th17 qauvmuab cov txheej txheem muaj tseeb dua rau kev soj ntsuam cov tshuaj ua tau zoo thiab cov txheej txheem immunomodulatory.
Prisys Biotech's Th17-Driven NHP Platform
Prisys Biotech tau tsim lub tswv yim tswj kev txhaj tshuaj tiv thaiv kab mob uas muaj kev ntseeg siab ua rau Th17- cov tshuaj tiv thaiv kab mob tsis txaus ntseeg hauv cynomolgus liab. Lub platform no tuaj yeem tsim kho los txhawb cov pov thawj ntxov- ntawm- tswvyim, mechanism- kev tshawb fawb ntawm kev ua, thiab kev soj ntsuam pharmacodynamic rau cov neeg sib tw tshuaj immunomodulatory.
Cov yam ntxwv tseem ceeb thiab qhov zoo
1. Ntau txoj kev txhaj tshuaj tiv thaiv kab mob kom zoo li Th17 teb
Lub platform txhawb intranasal thiab intramuscular txhaj tshuaj raws tu qauv, ua rau cov neeg soj ntsuam ntsuam xyuas ob qho tib si mucosal thiab lub cev tiv thaiv kab mob. Kev txhaj tshuaj Intranasal tau pom tias muaj txiaj ntsig tshwj xeeb hauv kev txhim kho mucosal Th17 cov lus teb, muab cov qauv tsim nyog rau kev sim nqus pa, mucosa- phiaj xwm, lossis tshuaj tiv thaiv- raws li kev cuam tshuam.
2. Kev Siv Tshuaj Tiv Thaiv Kab Mob thiab Cytokine Profiling
Cov txheej txheem analytical workflow tso cai rau ntau qhov kev ntsuam xyuas ntawm kev tiv thaiv kab mob:
- Serum cytokine kineticssuav nrog IL-17A, IFN-, IL-4, thiab cov cim cuam tshuam thoob plaws Th1/Th2/Th17 spectrum.
- Flow cytometric tsom xamntawm PBMCs, suav cov CD3⁺CD4⁺IL-17A⁺ Th17 cov pejxeem los saib xyuas cov lus teb ntawm tes ntawm qhov kev daws teeb meem siab.
- Cov ntaub so ntswg- kev ntsuas qib tiv thaiv kab mob, xws li splenic lossis pulmonary lymphocyte profiling, txhawm rau ntes cytokine ntau lawm ntawm cov chaw tiv thaiv kab mob hauv zos.
Qhov txheej txheem txheej txheem no muab cov ncauj lus kom ntxaws ntawm Th17 txoj hauv kev ua haujlwm thiab ua rau muaj kev ntsuam xyuas zoo ntawm kev kho cov kev hloov kho.
3. Kev Xaiv Viral Sib Tw rau Kev Nyeem Ntawv Ua Haujlwm
Rau cov tshuaj tiv thaiv lossis tiv thaiv kab mob- kev tshawb fawb tiv thaiv, lub platform tuaj yeem suav nrog kev sib tw kis kab mob hauv lub cev (xws li tus kab mob khaub thuas) tom qab txhaj tshuaj. Qhov no muab kev ntsuas kev ua haujlwm ntawm mucosal tiv thaiv kab mob thiab pab kom muaj nuj nqis ntawm Th17 cov lus teb rau kev tiv thaiv kev ua tau zoo.
4. Kev txhais lus siab rau kev txhim kho tshuaj
Vim muaj kev sib raug zoo ntawm kev tiv thaiv kab mob sib luag ntawm NHPs thiab tib neeg, tus qauv Th17 muab cov tshuaj pharmacodynamic thiab immunogenicity nyeem uas zoo dua kwv yees kev kho mob. Qhov no txo qis qhov tsis paub tseeb hauv kev txiav txim siab ua ntej thiab ntxiv dag zog rau cov ntaub ntawv pob rau IND xa.
Daim ntawv thov thoob plaws Autoimmune thiab Inflamation Research
- Kev ntsuam xyuas ntawm IL-17 / IL-23 pathway inhibitors, monoclonal antibodies, los yog me me -molecule modulators
- Kev ntsuam xyuas ntawm -cov tshuaj tiv thaiv tiam tom ntej, tshwj xeeb tshaj yog cov uas xav kom tshem tawm mucosal Th17 kev tiv thaiv
- Kab mob -kev tshawb fawb tshuabtsom rau Th17-mediated pathology
- Tshawb nrhiav kev tiv thaiv kab mob dynamicsnyob rau hauv lub hom phiaj kev cuam tshuam
Qhov yooj yim thiab qhov tob ntawm lub platform ua rau nws haum rau ob qho tib si tshawb nrhiav thiab lig - kev tshawb fawb preclinical.
Koom tes nrog Prisys Biotech
Prisys Biotech txhawb nqa thoob ntiaj teb cov kws kho mob thiab cov koom tes biotech los ntawm kev muab kev tshawb fawb nruj, kev kho mob cuam tshuamNHP qauv rau kev tiv thaiv kab mobthiab autoimmune tshuaj txhim kho. Peb Th17 platform yog tsim los pab kom meej meej mus / tsis tau- mus rau kev txiav txim siab, nkag siab txog kev nkag siab txog kev siv tshuab, thiab ua kom cov kev txhais cov kev kho tshiab tshiab rau kev soj ntsuam kev soj ntsuam.
Yog xav paub ntxiv txog kev sib tham lossis tshawb nrhiav cov qauv tsim kho, thov hu rau:
Email:bd@prisysbiotech.com
Lub Vev Xaib:www.prisysbiotech.com
