Cytokines ua haujlwm tseem ceeb ntawm kev sib txuas lus ntawm kev sib txuas lus, ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob thiab cov txheej txheem inflammatory. Interleukin-31 (IL-31), tus tswv cuab tseem ceeb ntawm Interleukin-6 (IL-6) cytokine tsev neeg, nrhiav tau nyob rau xyoo 2004, tau txais kev saib xyuas ntxiv rau nws lub luag haujlwm hauv kev tiv thaiv kab mob hauv lub cev thiab yoog raws. Kev tshawb fawb tau lees paub IL-31 qhov kev koom tes tseem ceeb hauv kev tiv thaiv kab mob thoob plaws ntau yam ntaub so ntswg thiab kab mob hauv nruab nrog cev, suav nrog daim tawv nqaij, ua pa, ntsws, thiab hnyuv. Qhov tseem ceeb, kev hloov pauv tsis tu ncua ntawm IL-31 qhia tau zoo sib xws nrog cov kab mob ntawm ntau yam kab mob, suav nrog pruritic dermatoses xws li Atopic Dermatitis (AD), Psoriasis, Asthma, thiab autoimmune tej yam kev mob xws li Mob plab hnyuv (IBD). Yog li ntawd, lub hom phiaj ntawm IL-31 thiab nws txoj kev taw qhia tau tshwm sim los ua qhov muaj txiaj ntsig zoo.tshuaj hom phiajnyob rau hauv lub kho thaj chaw ntawm autoimmune kab mob.
IL-31 Kev taw qhia txoj hauv kev thiab cov teebmeem lom neeg
IL-31 pib xa cov teeb liab qis los ntawm kev khi rau heterodimeric receptor complex ntawm lub xov tooj ntawm tes, muaj li ntawm Interleukin-31 Receptor A (IL-31RA) thiab Oncostatin M Receptor (OSMR). Receptor kev koom tes induces receptor complex dimerization thiab intracellular domain phosphorylation, tom qab activating canonical kinase signaling txoj kev, nrog rau covJAK/STAT, PI3K/Akt, thiabMAPKcascades. Ntawm qhov kev txaus siab tshwj xeeb, OSMR subunit tshwj xeeb nrhiav cov adapter protein SHC thiab phosphatase SHP-2, yog li txhawb nqa cov xwm txheej phosphorylation thiab ua kom muaj ntau haiv neeg MAPK cascade.
Kev ua haujlwm ntawm IL-31 kev taw qhia txoj hauv kev ua tiav hauv phosphorylation thiab nuclear translocation ntawm downstream transcription yam, thaum kawg tswj kev qhia ntawm lub hom phiaj noob. Cov kev tshawb fawb qhia tau hais tias IL-31 txoj kev taw qhia, nyob rau hauv ntau hom, hom cell, thiab cellular microenvironments, tuaj yeem hloov kho cov txheej txheem lom neeg, suav nrog kev muaj peev xwm ntawm cov lus teb inflammatory, cell migration, sib txawv, kev tswj ntawm kev loj hlob thiab apoptosis, thiab kev saib xyuas ntawm epithelial barrier muaj nuj nqi. Cov teebmeem lom neeg sib txawv no ua ke qhia txog lub luag haujlwm nyuaj ntawm IL-31 hauv cov kab mob pathogenesis.
IL-31 thiab Kab Mob autoimmune
Ob qhov kev soj ntsuam thiab cov pov thawj sim ua kom pom lub luag haujlwm tseem ceeb ntawm IL-31 hauv cov kab mob pathophysiology ntawm ntau yam kab mob autoimmune, tshwj xeeb tshaj yog nyob rau hauv pruritic dermatoses thiab inflammatory mob.
- Atopic Dermatitis (AD): Ntau qhov kev tshawb fawb tau lees paub qhov nce qib IL-31 hauv cov ntshav thiab cov ntaub so ntswg ntawm cov neeg mob Atopic Dermatitis, qhia txog kev sib raug zoo nrog pruritus hnyav thiab dermatitis ntau npaum li cas. IL-31 tau lees paub tias yog tus tsav tsheb tseem ceeb ntawm pruritus hauv AD thiab cuam tshuam rau hauv kev hloov kho ntawm Th2-type inflammatory teb.
- Chronic Pruritus: IL-31 yog suav hais tias yog tus kab mob hauv nruab nrab tus neeg nruab nrab hauv ntau yam mob pruritic. Txawm hais tias pruritus yog thawj dermatological lossis theem nrab rau cov kab mob hauv lub cev, IL-31 tuaj yeem kho qhov kev sib kis thiab kev nthuav dav ntawm pruritic signals.
- Psoriasis: Kev tshawb fawb qhia tias IL-31 qib hauv cov ntshav ntshav thiab cov kab mob psoriatic tau nce siab dua piv rau kev tswj hwm kev noj qab haus huv. IL-31 tuaj yeem ua rau cov lus teb inflammatory thiab epidermal hyperplasia nyob rau hauv psoriatic lesions, exacerbating qhov chaw kho mob tshwm sim ntawm tus kab mob.
- Mob hawb pob: IL-31 kuj plays lub luag hauj lwm nyob rau hauv lub pathogenesis ntawm mob hawb pob. Cov kev tshawb fawb qhia tias IL-31 tuaj yeem txhawb txoj hlab ntsws o, txhim kho txoj hlab ntsws hyperresponsiveness, thiab koom nrog cov txheej txheem pathological xws li kho cov hlab cua hauv kev mob hawb pob.
- Lwm yamCov kab mob autoimmune: Kev tshawb fawb ua ntej qhia tias IL-31 tuaj yeem cuam tshuam rau kev txhim kho thiab kev loj hlob ntawm lwm yam kab mob autoimmune, xws li Systemic Lupus Erythematosus (SLE) thiabRheumatoid mob caj dab (RA), txawm hais tias cov txheej txheem ntawm kev txiav txim siab xav tau ntxiv hauv - kev tshawb nrhiav tob.
Prisys Biotech NHP Cov Qauv Txhawb Kev Tshawb Fawb Preclinical rau IL-31-Targeted Therapies
Muab lub luag haujlwm tseem ceeb ntawm IL-31 hauv ntau yam kab mob autoimmune, lub hom phiaj IL-31 lossis nws txoj kev taw qhia tau dhau los ua qhov tseem ceeb hauv kev tshawb nrhiav tshuaj tshiab.Prisys Biotech, leveraging nws cov kev txawj ntse nyob rau hauvtsis yog-tib neeg primate (NHP) tsiaj qauvkev txhim kho thiab kev soj ntsuam tshuaj pharmacodynamic, tau tsim cov ntaub ntawv ntawmMacaca fascicularis autoimmune kab mob qauvuas ze recapitulate lub pathological yam ntxwv ntawm tib neeg kab mob. Qhov no yog tsom rau kev muabpreclinical qauvnrog txhim kho kev kho mob txhais lus rau IL-31-targeted tshuaj txhim kho.
Prisys Biotech tau ntse tsim ntau yamMacaca fascicularis autoimmune qauv, suav nrog cov qauv rauMob hawb pob, Psoriasis, Atopic Dermatitis (AD), thiabPruritus. Cov qauv no, hais txog cov kab mob pathophysiology, cov yam ntxwv ntawm kev tiv thaiv kab mob, thiab kev siv tshuaj tiv thaiv, ua tib zoo ua raws li cov yam ntxwv ntawm tib neeg cov kab mob, muab cov neeg tsim tshuaj muaj kev ntseeg siab thiab ua tau zoo.preclinical kev tshawb fawb platform.
Ntawm kev ceeb toom, lubPrisys BiotechMacaca fascicularis Pruritus Modelzoo simulates txoj kev loj hlob thiab kev loj hlob ntawm tib neeg pruritic tej yam kev mob. Cov qauv no tuaj yeem siv los ntsuas qhov ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj tiv thaiv tshiab los tiv thaiv -pruritic tshuaj tsom rau IL-31 thiab nws txoj kev taw qhia. Cov qauv no muaj feem xyuam rau txoj kev tshawb fawb ntawm pruritus cuam tshuam nrog thawj cov kab mob dermatological, nrog rau pruritus tshwm sim los ntawm cov kab mob hauv lub cev lossis lub paj hlwb, muab cov cuab yeej muaj zog rau kev ntsuam xyuas cov tshuaj tiv thaiv pruritic muaj peev xwm.
Lub Hom Phiaj Ntsuam Xyuas Pruritus nrog AI-Kev Ntsuas Tus Cwj Pwm Zoo:Prisys Biotech leverages lub tshiabAI-raws li NHP Behavior Analysis System (NBAS)los muab txoj hauv kev tsis muaj txiaj ntsig rau kev ntsuam xyuas pruritus hauv peb cov qauv NHP. Cov txheej txheem no siv cov txheej txheem kev kawm sib sib zog nqus thiab ntau - saib synchronization txhawm rau txhawm rau txhawm rau txheeb xyuas tus cwj pwm khawb thiab lwm yam tsis sib xws nrog qhov tseeb tshwj xeeb thiab lub cev qhov tseeb, nqes mus rau qhov thib ob. Los ntawm qhov tseeb taug qab ntau dua 21 lub ntsiab lus tseem ceeb ntawm lub cev thiab kev coj tus cwj pwm tsis zoo, NBAS rho tawm kinematic thiab kev coj noj coj ua tsis zoo cuam tshuam rau pruritus, muab kev nce qib tseem ceeb ntawm cov txheej txheem qhab nia ib txwm muaj. Cov thev naus laus zis no ua kom cov tsiaj muaj kev ntxhov siab tsawg kawg nkaus los ntawm nws qhov kev tsim tsis muaj cim thiab xa cov hom phiaj tsis tau pom dua thiab nthuav dav hauv kev ntsuam xyuas cov tshuaj tiv thaiv kab mob -pruritic kev ua tau zoo, kos ib qho kev hloov tshiab tseem ceeb hauv kev tshawb fawb txog kev mob pruritus.
Xaus thiab Outlook
IL-31, raws li ib qho tseem ceeb ntawm cov kab mob cytokine, ua lub luag haujlwm tseem ceeb hauv cov kab mob autoimmune xws li Atopic Dermatitis, Chronic Pruritus, Psoriasis, thiab Asthma. Targeting IL-31 thiab nws txoj kev taw qhia nthuav tawm cov kev taw qhia tshiab rau kev kho mob ntawm cov kab mob autoimmune.Prisys Biotechtau mob siab rau muab cov tuam txhab tshuaj thoob ntiaj teb nrog siab - zooNHP qauvthiab kws tshaj lijcov kev pab tshawb fawb preclinical. Peb tsimMacaca fascicularis autoimmune kab mob qauv, tshwj xeeb tshaj yogPruritus qauv, Atopic Dermatitis qauv, Psoriasis qauv, thiabAsthma qauv, yuav ua rau muaj txiaj ntsig zoo rau kev tsim kho tshiab ntawm IL-31-cov phiaj xwm kev kho mob, ua kom nrawm nrawm hauv kev kho mob autoimmune.
Hu rau Prisys Biotech Tam sim no
