Khaus (pruritus)yog ib qho ntawm cov tsos mob tshwm sim tshaj plaws ntawmAtopic Dermatitis (Ad), Kev tshawb nrhiav lub neej zoo li cas rau cov kev tshawb fawb no ua rau muaj kev puas tsuaj rau kev tawm tsam cov kev mob tawv nqaij no Qhov tseem ceeb ntawm cov tsiaj qauv muaj peev xwm ntawm kev hloov pauv ntawm cov txheej txheem thiab kev coj cwj pwm ntawm cov neeg muaj txiaj ntsig Biotech.
Kev siv tshuab puas nyob rau hauv atroppic dermatitis-txuam nrog khaus
Cov txheej txheem ntawm kev tshaj tawm khaus yog cov complex, muab cov kev tiv thaiv zoo nkauj rau cov hlwb thiab cov kev tiv thaiv kab mob hauv nruab nrab, thiab cov kev sib txuam ntawm cov hlab ntsha
Ntawm cov molecular pab cuam tshuam ntawm kev hloov khaus,interlekin -31(It {-31) Ua si lub cim tseem ceeb (}}}}}}} prisys biotech'sTsis yog-tib neeg kev ua yeeb yam (NHP) qauvyog tsim los pab txhawb kev tshawb fawb preclinical preping ★} {}}}}}}}}}}}}}}}}}}} Lwm tus neeg sib kho, xws li Neuropeptides (e.g., Tshuaj xyuas p), cov kev tiv thaiv, thiab hloov chaw muaj peev xwm (TRP) muaj peev xwm (TRP)
Cov kev kho uas twb muaj lawm, suav nrog cov ntsiab lus tsis yooj yim, feem ntau muaj qhov tseem ceeb ntawm kev txhim kho cov kev kho mob tshiab uas yog kev txhim kho cov kev kho mob molecular no.
Qhov tshwj xeeb ntawm NHP qauv rau khaus khaus
NHP qauv muaj cov txiaj ntsig zoo hauv kev tshawb fawb txog kev paub txog lawv lub cev, thiab tus cwj pwm zoo sib xws rau tib neeg {{prisys biotech'scynomolgus tooj liabyog ua kom zoo rau kev kawm paub cov tshuaj thiab ntsuas cov tshuaj sib txawv ntawm cov tshuaj uas tseem ceeb:
Kev coj cwj pwm txawv:
Piv txwv li tus cwj pwm ntawm NHPS zoo ib yam li ntawm tib neeg, ua rau cov qauv biote) Lub hom phiaj tsom .
Piv piv cov kev coj ua:
Cov kev xav neurons thiab cov kab mob khaus khaus khaus hauv NHP ua kom pom qhov zoo sib xws ntawm tib neeg txoj kev tshawb fawb tau ua hauv cov qauv no.
Simulation ntawm cov khaus khaus:
NHP cov qauv yuav ua rau muaj txiaj ntsig zoo rau cov kev mob siab khaus khaus khaus khaus khaus ntawm tib neeg, ua rau lawv muaj kev cuam tshuam dab tsi los xij
Daim tawv nqaij Physiology zoo ib yam:
Cov lus teb ntawm NHP daim tawv nqaij rau pruritogens, raws li nws cov tshuaj papmentability, kom zoo dua kev ntseeg tau los ntawm kev ua tau tshuaj zoo hauv kev ua tau kev pab tshuaj yeeb
Il -31-} indued khaus qauv:
Prisys biotech tau tsimIl -31-} indued khaus qauvHauv cynomolgus liab siv intradermal txhaj tshuaj ntawm recomolggus liab ★}} {} -31}}-31}}}}}}}}}}}} khaus .
Prisys biotech cov cynomolgus Monkey Ad Qauv
Prisys biotech txoj kev sib tw nwsCynomolgus Monkey Ad QauvTxhawm rau muab cov tshuaj ntsuam xyuas thiab txhim khu kev qha cov tshuaj uas muaj txiaj ntsig los tiv thaiv kab mob los tiv thaiv cov qauv no muaj:
Kev Soj Ntsuam Kev Coj Tus Cwj Pwm thiab Quaeification:
Prisys ntiavAi-Raws NHP Kev Txheeb Xyuas Tus Cwj Pwm, suav nrog HD Video Koob Yees Duab thiab cov software tshwj xeeb (e {. g.,Coj tus cwj pwm), rau objectively lawb tawm . Cov kev coj ua, kev coj tus cwjpwm kom paub meej, nrog kev coj tus cwjpwm kom paub tseeb, nrog cov xwm txheej tshaj tawm, nrog cov xwm txheej tshaj tawm, thiab cov xwm txheej uas tau txiav txim siab, nrog cov xwm txheej tshaj tawm, nrog cov xwm txheej tshaj tawm rau hauv 1- teev sij hawm mus taug kev cuam tshuam .
Cov neeg kuaj mob tawv nqaij:
Prisys biotech siv cov qauv zoo los ntsuas qhov mob tawv nqaij uas tau ua rau pom kev muaj peev xwm ntawm NHKSION kev txhim kho cov tawv nqaij cov tawv nqaij hauv cov qauv .
Biomarker Nrhiav Kom Tau:
Biomarker Kev Tshawb Xyuas Ib qho tseem ceeb ntawm prisys biotech lub peev xwm thiab cov tshuaj uas muaj cov tswv yim hauv lub cev muaj zog txhawb nqa cov tshuaj tiv thaiv ntawm cell litics, xws li lymphocyte beets, thiab lwm yam cuam tshuam biomarkers .
Keeb kwm kev tsom xam:
Prisys tau tsim cov kev hloov kho mob histopathology rau kev hloov pauv ntawm daim tawv nqaij, suav nrog kev ua haujlwm ntawm tes, nrog rau kev ua yeeb yam ntawm tes, staining, thiab immunohistochemistry yog conducted nyob rau hauv-lub tsev, kom ntseeg tau cov kev ntsuas zoo. kev tshawb nrhiav lub peev xwm tso cai rau cov qauv siv rau cov kev ntsuas ntev {}}
Cov Kev Tswj Yeeb Txheej Txheem:
Prisys biotech muaj ntau txoj kev ntawm kev kho yeeb tshuaj thiab subcutous thiab substic kws kho mob {}} Cov txheej txheem kev ntsuas ntawm kev ua yeeb yam tshuaj yeeb tshuaj thiab cov kws muag tshuaj .
Cov Kev Pab Cuam Neeg:
Los ntawm kev siv prisys biotech's cynomolgus tus qauv ntawm kev txhim kho kev txhim kho, cov neeg siv khoom lag luam {}}
Tsim kho cov kws kho mob ua haujlwm zoo rau antiscic dermatitis yuav tsum muaj zog thiab cath} prisys biotech'sCynomolgus Monkey Ad Qauvmuaj qhov kev pab txhais lus tshwj xeeb los ntawm kev sib txuas ua ke ntawm kev kho cov tshuaj uas muaj peev xwm txhim khu kev txhim kho cov kev xav tau hauv ad-pruritus tswj hwm .
Puas yog koj tshawb nrhiav cov kev daws teeb meem los tiv thaiv kab mob pruritic? Tus khub nrog prisys biotech los ntsuas koj cov neeg sib tw tshuaj siv pebcynomolgus tooj liab.} Hu rau peb niaj hnub no los tham txog seb peb yuav pab tau koj cov kev tshawb fawb xav tau li cas.
