Mob raum Kab Mob (CKD) tau tshwm sim raws li kev sib tw kev noj qab haus huv thoob ntiaj teb, pom los ntawm kev mob ntev, kev ua haujlwm tsis zoo ntawm lub raum. Lub raum fibrosis, tshwj xeeb tshaj yog tubulointerstitial fibrosis, sawv cev rau txoj hauv kev zoo kawg nkaus kom xaus- kab mob raum nyob rau hauv yuav luag txhua tus mob CKD. Lub pathogenesis yog complex, nrog rau mob o, TGF - signaling, oxidative kev nyuaj siab, metabolic cuam tshuam, thiab genetic susceptibility.
Txhawm rau ua kom nkag siab txog CKD pathogenesis thiab tsim cov tswv yim kho tshiab, cov qauv kab mob zoo yog qhov tseem ceeb. Ntawm cov no, Unilateral ureteral Obstruction (UUO) qauv sawv tawm rau nws lub peev xwm los ua kom rov zoo dua cov txheej txheem pathological ntawm obstructive nephropathy hauv tib neeg.
Qhov zoo ntawm Non-Human Primate (NHP) CKD Models
Tsis yog-tib neeg primate (NHP) qauv ntawm cov kab mob raum ntev muaj ntau yam zoo hauv kev simulating tib neeg CKD thiab nws txoj kev loj hlob mus rau fibrosis:
- Progressive raum Fibrosis: NHP qauv nthuav tawm gradual kev loj hlob ntawm interstitial fibrosis, tus yam ntxwv los ntawm ntau deposition ntawm extracellular matrix (ECM) proteins xws li collagen, mirroring cov txheej txheem fibrotic pom nyob rau hauv tib neeg CKD.
- Inflammatory teb: Zoo ib yam li tib neeg CKD, NHP qauv qhia cov lus teb inflammatory nyob rau hauv lub raum, nrog rau cov kab mob ntawm tes infiltration thiab tso tawm pro-fibrotic cytokines.
- Kev poob qis hauv lub raum ua haujlwm: NHP cov qauv qhia txog kev poob qis hauv lub raum ua haujlwm, raws li ntsuas los ntawm glomerular filtration rate (GFR) thiab lwm yam ntsuas, qhia txog kev ua haujlwm tsis zoo hauv tib neeg CKD.
- Sib piv Histopathological nta: NHP cov qauv qhia txog cov yam ntxwv histopathological zoo ib yam li tib neeg lub raum fibrosis, suav nrog tubular atrophy, interstitial o, thiab glomerulosclerosis.
Piv nrog rau cov qauv nas, NHP CKD qauv muaj qhov tshwj xeeb zoo:
- Closer Human Disease Mimicry: Lub raum thiab lub cev tiv thaiv kab mob ntawm NHPs yog qhov zoo sib xws rau tib neeg, tso cai rau kom muaj qhov tseeb dua sawv cev ntawm cov kab mob thiab cov lus teb kho mob.
- Lub raum Loj: Qhov loj dua ntawm NHP ob lub raum tso cai rau cov kev tshawb fawb ntxaws ntxaws thiab kev tsom xam ntawm lub raum qauv thiab kev ua haujlwm, muab kev nkag siab tob rau hauv cov txheej txheem kab mob.
- Similar Drug Metabolism: NHPs qhia ntau txoj hauv kev zoo sib xws ntawm cov tshuaj metabolism nrog tib neeg piv rau cov nas, muab kev kwv yees txhim khu kev qha ntawm kev siv tshuaj thiab kev nyab xeeb hauv kev sim tshuaj.
Prisys Biotech's Renal Fibrosis Model
Prisys Biotech tau tsim kom muaj ib tug zoo-tus qauv mob raum mob raum nyob rau hauv cynomolgus liab, siv cov qauv no kom ua tiav cov kev ntsuam xyuas ua tau zoo ntawm preclinical kev soj ntsuam ntawm ntau yam tshiab kho.
Qauv Tsim:
Prisys Biotech's cynomolgus liab CKD qauv replicates lub pathological nta ntawm CKD los ntawm ib tug meej ua unilateral ureteral obstruction (UUO) phais. Kev loj hlob ntawm tus kab mob thiab kev hloov pauv pathological hauv cov qauv no ua rau pom cov neeg pom hauv tib neeg.
Clinical Endpoints:
- Lub raum fibrosis histopathology
- Qib Hydroxyproline
- Kev ntsuas lub raum ua haujlwm
- Inflammatory response markers
- Lub raum loj
Qauv Zoo:
Prisys Biotech's cynomolgus liab CKD-UUO qauv qhia txog kev ua haujlwm qeeb qeeb ntawm fibrosis, ua kom raug simulating cov yam ntxwv ntawm tib neeg tubulointerstitial fibrosis, nrog rau qhov tseem ceeb hauv qab daus membrane expansion thiab interstitial cell infiltration. Cov qauv no yog qhov tsim nyog rau kev ntsuas qhov ua tau zoo, lub hom phiaj kev sib koom tes, thiab cov tshuaj pharmacokinetics ntawm cov tshuaj tiv thaiv -fibrotic.
Prisys Biotech Covnephrology platformnthuav dav ntawm qhov ua tiav ntawm lawv cov cynomolgus liab CKD-UUO qauv los ntawm kev tsim cov qauv ntxiv, suav nrogMob raum mob (AKI), Focal Segmental Glomerulosclerosis (FSGS), thiab IgA Nephropathy (IgAN). Cov qauv no muab cov cuab yeej muaj zog rau kev kawm txog cov txheej txheem, kab mob, thiab kev kho mob rau ntau yam kab mob hauv lub raum, ua kom muaj kev vam meej hauv kev tshawb fawb nephrology thiab kev tsim tshuaj.
Huang, Linghong, et al. "Cov nyhuv ntawm TG2-inhibitory monoclonal antibody zampilimab ntawm cov ntaub so ntswg fibrosis hauv tib neeg hauv vitro thiab primate hauv vivo qauv ntawm cov kab mob raum ntev."Plos ib 19.5 (2024): e0298864.
Huang, Linghong, et al. "Kev txhim kho ntawm unilateral ureteral obstruction qauv hauv cynomolgus liab."Tsiaj qauv thiab kev sim tshuaj 4.4 (2021): 359-368.
