Nyob rau hauv preclinicalpharmaconininetics (pk), Cov thawj coj tswj yeeb tshuaj tsis yog ib kauj ruam tseem ceeb - Nws yog lub hauv paus ntseeg tau los ntseeg kev ntsuas, kev sim siab rau tib neeg kev sim siab. Ntawm Prisys Biotech, cov thawj coj tshwj xeeb hauv cov tsiaj loj, suav nrog cynomolgus liab, peb qhia txog qhov precision thiab qauv hauv txhua qhov ntawm kev siv koob tshuaj. Kab lus no qhia txog cov kev txiav txim siab tseem ceeb rau cov khoom tseem ceeb (IV) thiab qhov ncauj (PO) Dosing ntim, phua, thiab kev chim siab, tshwj xeeb, tshwj xeeb yog nyob rau hauvTus qauv NHP, txhawm rau txhawb kev coj ua thiab cov khoom siv khov kho ntau tiam neeg.
Lub luag haujlwm ntawm PK hauv kev tsim tshuaj
Pharmaconinetics ua ib qho "taug kev log" rau cov neeg sib tw tshuaj, taug qabKev nqus tau, faib, cov metabolism, thiab ua kom zoo nkauj (khav theeb)Cov. Qhov tseeb PK kev tshawb fawb muab kev nkag siab muab kev nkag siab, cov npoo kev nyab xeeb, thiab cov ntaub ntawv tseem ceeb {} {}}}}}}} pagease kev sib tw. Cov tswj hwm cov tswj hwm lossis cov qauv tsim nyog tuaj yeem ua rau muaj kev cuam tshuam los yog ua txhaum cov qauv kev nyab xeeb tsiaj.
Hom -} Tshwj Xeeb Dosing Ntim Cov Lus Qhia
Kev ntim khoom yuav tsum raug yoog raws li hom physiology. Overdosing -} Txawm hais tias nyob rau hauv cov lus ntawm cov kua dej ntim {2} Yuav ua rau muaj kev ntxhov siab, kev xav, lossis kev ntxhov siab metabolic. Cov lus 1 muab feem ntau lees txais qhov ntau tshaj plaws rau IV thiab Po cov kev hla tebchaws:
Cov lus 1: Pom zoo kom ntau npaum li cas Dosing ntawm hom
| Hom | IV (ml / kg) | PO (ML / KG) | Sau ntawv |
|---|---|---|---|
| Tus nas | 5 | 10 | Lub plab mog lub plab yog txwv; 10 ml / kg yuav txaus ntshai regurgitation |
| Tus nas | 5 | 10 | Kev yoo mov txhim kho kev nqus |
| Tus aub | 5–10 | 5–15 | Cov tsiaj loj tiv thaiv ntau dua |
| NHP (piv txwv li, cynomolgus) | Tsawg dua los yog sib npaug rau 5 | Tsawg dua los yog sib npaug rau 5 | Tshaj 5 ml / kg / kg yuav induce ntuav |
Prisys bierech adheres rau kev saib xyuas kev txwv kom ntseeg tau NHP Welfare thaum Maximizing cov ntaub ntawv ncaj ncees.
Dosing Piv Txwv: Kev Ntsuas Cov Khoom Yuav Tsum Rau Cov Mice
Los qhia txog yuav ua li cas cov qauv thiab cov dosing ntim cuam tshuam cov khoom siv xav tau:
Po Piv Txwv(10 mg / kg): Rau 25g nas ntawm 10 ml / kg, qhov xav tau tshuaj uas xav tau yog 1 mg / ml.
Pawg ntawm 3 nas: 0.75 MG Tag nrho cov compound xav tau.
IV piv txwv(1 mg / kg): ntawm 5 ml / kg, concentration {}} mg / ml.
Thaum theoretically qhov kev sim siab, tiag tiag sim cov khoom siv rau qhov raug hnyav, thiab lc} ms / mS txheem nkhaus} ib txwm muaj 5-7 mg ib qho compound.
Qhov tseem ceeb ntawm PHIC kev tswj hwm hauv kev tsim
PH kev hloov kho feem ntau yuav tsum tau txhim kho solubility, tshwj xeeb rau cov tebchaw yooj yim. Txawm li cas los xij, cov txiaj ntsig heev yuav ua rau lub ntsej muag ncaj ncees lossis ua rau muaj kev ntseeg siab lossis tsis muaj txiaj ntsig}- Tshwj xeeb hauv cov tsiaj zoo li NHP.
Rooj 2: Pom zoo tsim cov lus ntawm hom
| Hom | Ph ntau | Hais lus |
|---|---|---|
| Nas / nas | 3.0–8.0 | Zam Txim Ph<2.5 or >9 |
| Tus aub | 4.0–8.0 | Rhiab rau acidic tej yam kev mob ( |
| Nhp | 5.0–7.0 | Raws li cov lus qhia txog tib neeg |
Ntawm prisys, peb ib txwm ua kom ua tau zoo rau dlemic nrog hom - Cov kev tsim txom tshwj xeeb thaum tswj cov solubility thiab kev ruaj khov.
Osmolarity thiab cov kev txiav txim siab
High - uts uts -}}} Cov kuab tshuaj zoo li DMOs yuav tsum tau ua tib zoo tswj:
DMSO >10%: Kev phom sij ntawm ulceration.
DMOPS tsawg dua lossis sib npaug rau 5%: Xam tias muaj kev nyab xeeb dua.
Ntaus tswv yim: Txo tag nrho cov ntim khoom lossis tshawb nrhiav lwm qhov kev zam rau cov solubilization.
Cov kev sib tw nyuaj no yog qhov tseem ceeb tshaj plaws hauv NHP kev tshawb fawb vim lawv rhiab thiab muaj nuj nqis. Peb cov kws ua haujlwm ntawm prisys Biotech Tailor tsheb los ua kom sib npaug ntawm solubility, thev taus, thiab pk ua haujlwm.
Tag
Txhua txoj kev kawm PK pib nrog kev txiav txim siab Dosing - thiab hauv cov kev tshawb fawb uas nqa cov ntaub ntawv ua tau zoo thiab kev ua tiav. Ntawm Prisys Biotech, peb loj- tsiaj muaj kev ntseeg tau tias koj cov compound yog xa tawm kev nyab xeeb thiab reprocibly, thoob plaws NHP thiab lwm hom. Los ntawm kev tswj hwm nruj ntawm cov ntim, pH, peb pab txhawb nqa ua ntej tsim cov ntaub ntawv PK ua haujlwm ntawm cov qauv tsiaj.
Hais txog prisys biotech
Prisys biotech yog ib qho kev tshwj xeeb cro tshwj xeeb hauvLoj -} Cov Tsiaj Sib Tham, tshwj xeeb nrog cynomolgus liab. Peb txoj kev sib xyawPk / pd, Toxicology, thiabKev Ntsuas Lub PlatformTxhawb ind - Enabling thiab thaum ntxov-}}}}}}}} ure scientific nruj thiab tswj kev ua raws.
